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| 1 | 在肝的 G6PT-H6PDH-11HSD1 三个一组和它在新陈代谢的症候群的 pathomechanism 的含意显示文摘 The metabolic syndrome, one of the most common clinical conditions in recent times, represents a combination of cardiometabolic risk determinants, including central obesity, glucose intolerance, insulin resistance, dyslipidemia, non-alcoholic fatty liver disease and hypertension. Prevalence of the metabolic syndrome is rapidly increasing worldwide as a consequence of common overnutrition and consequent obesity. Although a unifying picture of the pathomechanism is still missing, the key role of the pre-receptor glucocorticoid activation has emerged recently. Local glucocorticoid activation is catalyzed by a triad composed of glucose-6-phosphate-transporter, hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum. The elements of this system can be found in various cell types, including adipocytes and hepatocytes. While the contribution of glucocorticoid activation in adipose tissue to the pathomechanism of the metabolic syndrome has been well established, the relative importance of the hepatic process is less understood. This review summarizes the available data on the role of the hepatic triad and its role in the metabolic syndrome, by confronting experimental findings with clinical observations. | Ibolya Czegle Miklós Csala József Mandl Angelo Benedetti István Karádi Gábor Bánhegyi | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 2 | Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factors显示文摘 | Elizabeth W Karlson Lisa A Mandl Gideon N Aweh Oliver Sangha Matthew H Liang Francine Grodstein | 2003 | The American Journal of Medicine2003，，2： | 1 |
| 3 | A comparison of alpha and beta diversity patterns of ferns, bryophytes and macrolichens in tropical montane forests of southern Ecua- dor 显示文摘 | Mandl N Lehnert M Kessler M | 2010 | Biodiversity and Conservation2010，19，8： | 1 |
| 4 | Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase显示文摘 | Fanni S. Kálmán Beáta Lizák Szilvia K. Nagy Tamás Mészáros Veronika Zámbó József Mandl Miklós Csala éva Kereszturi | 2013 | Biochimie2013，，7： | 1 |
| 5 | An osteochondral culture model to study mechanisms involved in articular cartilage repair显示文摘 | Marloes L Mandl EW Kops N | 2012 | Tissue Eng Part C Methods2012，18，1： | 1 |
| 6 | Shear zones in granular materials:an experimental study of their structure and mechanical genesis显示文摘 | Mandl G de Jong L N J Maltha A | 1977 | Rock Mechanics1977，9，1： | 1 |
| 7 | Unknown effect of amino acids显示文摘 | Mandl L A N | 1948 | Arch Biochem1948，19，2： | 1 |
| 8 | Shear zones in granular material显示文摘 | MANDL G DE JONG L N S MALTHA A | 1977 | Rock Mechanics1977，9，： | 1 |
| 9 | Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factors显示文摘 | Karlson E W Mandl L A Aweh G N | 2003 | Am J Med2003，114，2： | 1 |
| 10 | Diver- gent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections 显示文摘 | MANDL J N BARRY A P VANDERFORD T H | 2008 | Nat Med2008，14，10： | 1 |
| 11 | Evidence for a non- linear relationship between fracture spacing and layer thickness显示文摘 | Mandl N | 1994 | Journalof Structural Geology1994，16，9： | 1 |
| 12 | Reservoir host immune responses to emerging Zoonotic viruses 显示文摘 | Mandl J N Ahmed R Barreiro L B | 2015 | Cell2015，160，12： | 1 |
| 13 | T cell-positive selection uses self-ligand binding strength to optimize reper- toire recognition of foreign antigens显示文摘 | Mandl JN Monteiro JP Vrisekoop N | 2013 | Immunity2013，38，： | 1 |
| 14 | Coffee con- sumption and risk of rheumatoid arthritis 显示文摘 | KARLSON E W MANDL L A AWEH G N | 2003 | Arthritis Rheum2003，48，11： | 1 |
| 15 | Shear zones in granular material显示文摘 | Mandl G Dejong L N J Maltha A | 1977 | Rock Mechanics1977，9，： | 1 |
| 16 | How Often are Patient and Surgeon Recovery Expectations for Total Joint Arthroplasty Aligned Results of a Pilot Study显示文摘 | Ghomrawi HM Franco Ferrando N Mandl LA | | 0，，03： | 1 |
| 17 | Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway显示文摘 | GAKHAR-KOPPOLE N HUNDESHAGEN P MANDL C | | 0，，5： | 1 |
| 18 | Differential glucocorticoid effects on proliferation and invasion of human trophoblast cell lines 显示文摘 | Mandl M Ghaffari T N Haas J | 2006 | Reproduction2006，132，1： | 1 |
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