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| 1 | Role of endoscopic vacuum therapy in the management of gastrointestinal transmural defects显示文摘A gastrointestinal(GI) transmural defect is defined as total rupture of the GI wall,and these defects can be divided into three categories: perforations,leaks,and fistulas. Surgical management of these defects is usually challenging and may be associated with high morbidity and mortality rates. Recently,several novel endoscopic techniques have been developed,and endoscopy has become a firstline approach for therapy of these conditions. The use of endoscopic vacuum therapy(EVT) is increasing with favorable results. This technique involves endoscopic placement of a sponge connected to a nasogastric tube into the defect cavity or lumen. This promotes healing via five mechanisms,including macrodeformation,microdeformation,changes in perfusion,exudate control,and bacterial clearance,which is similar to the mechanisms in which skin wounds are treated with commonly employed wound vacuums. EVT can be used in the upper GI tract,small bowel,biliopancreatic regions,and lower GI tract,with variable success rates and a satisfactory safety profile. In this article,we review and discuss the mechanism of action,materials,techniques,efficacy,and safety of EVT in the management of patients with GI transmural defects. | Diogo Turiani Hourneaux de Moura Bruna Furia Buzetti Hourneaux de Moura Michael A Manfredi Kelly E Hathorn Ahmad N Bazarbashi Igor Braga Ribeiro Eduardo Guimaraes Hourneaux de Moura Christopher C Thompson | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，5： | 6 |
| 2 | Struc-ture-properties relationship for resols with different formalde-hyde/phenol molar ratio显示文摘 | Manfredi L B de la Osa O Galego Fernandez N | 1999 | Ploymer1999，40，13： | 1 |
| 3 | Oli-gomycin induces a decrease in the cellular content of a pathogenicmutation in the human mitochondrial ATPase 6 gene显示文摘 | MANFREDI G GUPTA N VAZQUEZ MEMUE ME | 1999 | J BiolChem1999，274，14： | 1 |
| 4 | Genetic polymorphisms in folate and homocysteine metabolism as risk factors for DNA damage 显示文摘 | Botto N Andreassi MG Manfredi S | 2003 | Eur J Hum Genet2003，11，9： | 1 |
| 5 | Vinylene - linked pyridine - pyrrole donor - acceptor conjugated polymers 显示文摘 | Abbotto A Calderon E H Manfredi N | 2011 | Synthetic Metals2011，161，910： | 1 |
| 6 | Probabilistic GIS- based method for delineation of urban flooding risk hotspots显示文摘 | JALAYER F DE RISI R DE PAOLA F GIUGNI M MANFREDI G GASPAR1NI P TOPA M E YONAS N YESHITELA K NEBEBE A CAVAN G LINDLEY S PRINTZ A RENNER F | 2014 | Natural Hazards2014，73，2： | 1 |
| 7 | Genetic polymorphisms in folate and homocysteine metabolism as risk factors for DNA damage显示文摘 | Botto N Andreassi MG Manfredi S | 2003 | Eur J Hum Genet2003，11，9： | 1 |
| 8 | Structure-properties relationship for resols with different formaldehyde/phenol molar ratio显示文摘 | Manfredi L B Osa O de la Fernandez N G | 1999 | Polymer1999，40，： | 1 |
| 9 | Trends in incidence and management of gallbladder carcinoma:a population-based study in France显示文摘 | Manfredi S Benhamiche AM Isambert N | | 0，，： | 1 |
| 10 | AIDS-related visceral as pergillosis:an underdiagnosed disease during life显示文摘 | Salfi N Alampi G | 1998 | Mycoses1998，41，1112： | 1 |
| 11 | Genetie polymorphisms in folate and homoeysteine metabolism as risk factors for DNA damage显示文摘 | Botto N Andreassi MG Manfredi S Masetti S Cocci F | 2003 | Eur J Hum Genet2003，11，9： | 1 |
| 12 | Review in depth and meta-analysis of controlled trials on colorectal cancer screening by faecal occult blood test显示文摘 | He resbach D Manfredi S Halluin P N | 2006 | European Journal of Gastroenterology&Hepatology2006，18，4： | 1 |
| 13 | Genetic polymor- phisms in folate and homocysteine metabolism as risk factors for DNA damage 显示文摘 | Botto N Andreassi MG Manfredi S | 2003 | Eur J Hum Genet2003，11，9： | 1 |
| 14 | An Object- oriented Approach for Flexible Manufacturing Control Systems Analysis and Design using the Unified Modeling Language显示文摘 | Manfredi B Sergio N L D Giovanni P | 2003 | International Journal of Flexible Manufacturing Systems2003，15，3： | 1 |
| 15 | Structure- properties relationship for resols with different formaldehyde/ phenol molar ratio显示文摘 | Manfredi L B Osa O de la Fernandez N G | 1999 | Polymer1999，40，13： | 1 |
| 16 | Trends in incidence and management of gallbladder carcinoma: s populationbased study in France显示文摘 | Manfredi S Benhamiche AM Isambert N | 2000 | Cancer2000，89，4： | 1 |
| 17 | Antitumor activity of MLN8054,an orally active small-molecule inhibitor of Aurora A kinase 显示文摘 | MANFREDI N G ECSEDY J A MEETZE K A | 2007 | P Natl Acad Sci USA2007，104，10： | 1 |
| 18 | Review in depth and meta-analysis of controlled trails on colorectal cancer screening by faecal occult blood test 显示文摘 | Heresbach D Manfredi S D'halluin P N | 2006 | Eur J Gastroenterol Hepatol2006，18，4： | 1 |
| 19 | Detection of mtDNA with 4977 bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease显示文摘 | Botto N Berti S Manfredi S Al-Jabri A Federici C Clerico A | 2005 | Mut Res2005，570，： | 1 |
| 20 | Detection of mtDNA with 4977 bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease显示文摘 | Botto N Berti S Manfredi S | 2005 | Mutat Res2005，570，1： | 1 |
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