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| 1 | Effectiveness of very low-volume preparation for colonoscopy:A prospective, multicenter observational study显示文摘BACKGROUND The effectiveness of colonoscopy strictly depends on adequate bowel cleansing.Recently,a 1 L polyethylene glycol plus ascorbate(PEG-ASC)solution(Plenvu;Norgine,Harefield,United Kingdom)has been introduced on the evidence of three phase-3 randomized controlled trials,but it had never been tested in the real-life.AIM To assess the effectiveness and tolerability of the 1 L preparation compared to 4 L and 2 L-PEG solutions in a real-life setting.METHODS All patients undergoing a screening or diagnostic colonoscopy after a 4,2 or 1 L PEG preparation,were consecutively enrolled in 5 Italian centers from September 2018 to February 2019.The primary endpoints of the study were the assessment of bowel cleansing success and high-quality cleansing of the right colon.The secondary endpoints were the evaluation of tolerability,adherence and safety of the different bowel preparations.Bowel cleansing was assessed through the Boston Bowel Preparation Scale.Adherence was defined as consumption of at least 75%of each dose,while tolerability was evaluated through a semiquantitative scale.Safety was systematically monitored through adverse events reporting.RESULTS Overall,1289 met the inclusion criteria and were enrolled in the study.Of these,490 patients performed a 4 L-PEG preparation(Selgesse^■),566 a 2 L-PEG cleansing(Moviprep^■or Clensia^■)and 233 a 1 L-PEG preparation(Plenvu^■).Bowel cleansing by Boston Bowel Preparation Scale was 6.5±1.5 overall and 6.3±1.5,6.2±1.5,7.3±1.5(P<0.001)in the subgroups of 4 L,2 L and 1 L-PEG preparation,respectively.Cleansing success was achieved in 72.4%,74.1%and 90.1%(P<0.001),while a high-quality cleansing of the right colon in 15.9%,12.0%and 41.4%(P<0.001)for 4 L,2 L and 1 L-PEG preparation groups,respectively.The 1 L preparation was the most tolerated compared to the 2 and 4 L-PEG solutions in the absence of serious adverse events within any of the three groups.Multiple regression models confirmed 1 L PEG-ASC preparation as an independent predictor of overall cleansing success,high-quality cleansing of the right colon and of tolerability.CONCLUSION This study supports the effectiveness and tolerability of 1 L PEG-ASC,also showing it is an independent predictor of overall cleansing success,high-quality cleansing of the right colon and of tolerability. | Marcello Maida Emanuele Sinagra Gaetano Cristian Morreale Sandro Sferrazza Giuseppe Scalisi Dario Schillaci Marco Ventimiglia Fabio Salvatore Macaluso Giovanni Vettori Giuseppe Conoscenti Concetta Di Bartolo Serena Garufi Domenico Catarella Michele Manganaro Clara Maria Virgilio Salvatore Camilleri | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 2 | Diffusion-weighted MR imaging and apparent diffusion coefficient of the normal fetal lung : preliminary experience显示文摘 | Manganaro L Perrone A Sassi S | 2008 | Prenat Diagn2008，28，8： | 1 |
| 3 | Plasma leptin,insulin,and neuropeptide Y concentrations in infants显示文摘 | Manganaro R Saitta G | 2005 | Arch Dis Child Fetal Neonatal Ed2005，90，1： | 1 |
| 4 | Surgical correction of penos- crotal transposition associated with hypospadias and bifid scrotum: our experience of two-stage repair显示文摘 | Arena F Romeo C Manganaro A | 2005 | J Pediatr Urol2005，1，4： | 1 |
| 5 | QSAR modelling of carcinogenicity by balance of correlations显示文摘 | A A Toropov A PToropova E Benfenati A Manganaro | 2009 | Molecular Diversity2009，13，3： | 1 |
| 6 | Incidence of biopsy-proven primary glomerulonephritis in an Italian Province显示文摘 | Piero Stratta Giuseppe P. Segoloni Caterina Canavese Luisa Sandri Gianna Mazzucco Dario Roccatello Marco Manganaro Antonio Vercellone | 1996 | American Journal of Kidney Diseases1996，，5： | 1 |
| 7 | Human recombinant mullerian inhibitory subatnce inhibition of rat oocyte meiosis is reversed by epidermal growth factor in vitro显示文摘 | Manganaro T F Donahoe P K | 1988 | Endocrinology1988，123，： | 1 |
| 8 | Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in critically ill patient显示文摘 | Taylor RW Manganaro L O'Brien J | 2002 | Crit Care Med2002，30，： | 1 |
| 9 | Fetal MRI with dif fusion weighted imaging (DWI) and apparent diffusion coeffi cient (ADC) assessment in the evaluation of renal development preliminary experience in normal kidneys显示文摘 | Manganaro L Francioso A Savelli S | 2009 | Radiol Med2009，114，3： | 1 |
| 10 | Surgical ap- proach to nipple discharge: a ten-year experience显示文摘 | Gioffre Florio M Manganaro T Pollicino A | 1999 | J Surg Oncol1999，71，4： | 1 |
| 11 | New endoscopy advances to refine adenoma detection rate for colorectal cancer screening:None is the winner显示文摘Colorectal cancer(CRC) is the third most common cancer in males and second in females, and globally the fourth cause for cancer death worldwide. Oncological screening of CRC has a major role in the management of the disease and it is mostly performed by colonoscopy. Anyway, effectiveness of endoscopic screening for CRC strictly depends on adequate detection and removal of potentially precancerous lesions, and accuracy of colonoscopy in detection of adenomas is still suboptimal. For this reason, several technological advances have been implemented in order to improve the diagnostic sensitivity of colonoscopy in adenoma detection. Among these:(1) Visual technologies such as chromoendoscopy and narrow band imaging;(2) optical innovation as high definition endoscopy, full-spectrum endoscopy or Third Eye Retroscope; and(3) mechanical advances as Cap assisted colonoscopy, Endocuff, Endoring and G-Eye endoscope. All these technologies advances have been tested over time by clinical studies with mixed results. Which of them is more likely to be successful in the next future? | Marcello Maida Salvatore Camilleri Michele Manganaro Serena Garufi Giuseppe Scarpulla | 2017 | World Journal of Gastrointestinal Oncology2017，9，10： | 1 |
| 12 | Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in the critically ill patient显示文摘 | Taylor RW Manganaro L Or Brien J | 2002 | Crit Care Med2002，30，： | 1 |
| 13 | Renal involvement in systemic amyloidosis 显示文摘 | Bergesio F Ciciani AM Manganaro M | 2008 | Nephrol Dial Transplant2008，23，： | 1 |
| 14 | Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in the critically ill patient 显示文摘 | Taylor RW Manganaro L O' Brien J | 2002 | Crit Care Med2002，30，10： | 1 |
| 15 | Role of fetal MRI in the diagnosis of cerebral ventriculomegaly assessed by ultrasonography显示文摘 | Manganaro L Savelli S Francioso A | 2009 | Radiol Med2009，114，7： | 1 |
| 16 | Detection of microparticles from hu- roan red blood cells by rouhipararoetric flow cytometry 显示文摘 | Grisendi G Finetti E Manganaro D | 2015 | Blood Transfus2015，13，2： | 1 |
| 17 | Assessment of con- genital heart disease(CHD) :is there a role for fetal magnetic reso- nance imaging(MRI)? 显示文摘 | Manganaro L Savelli S Di Maurizio M | 2009 | Eur J Radiol2009，72，1： | 1 |
| 18 | Plasma leptin insulin and neuropeptide Y concentrations in infants显示文摘 | Mami C Manganaro R Saitta G | 2005 | Arch Dis Child Fetal Neonatal Ed2005，90，1： | 1 |
| 19 | A 14-b 100-MS/s pipelined ADC with a merged SHA and first MDAC 显示文摘 | LEE B MIN B MANGANARO G | 2008 | IEEE J Sol Sta Circ2008，43，12： | 1 |
| 20 | Surgical approach to nipple discharge: a ten-year experience 显示文摘 | Florio MG Manganaro T Pollicino A | 1999 | J Surg Oncol1999，71，4： | 1 |
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