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| 1 | Copy number increase of aurora kinase A in colorectal cancers: a correlation with tumor progression显示文摘联系中心体的 kinase 曙光 A (AURKA ) 涉及基因不稳定性并且在包括 colorectal 癌症(CRC ) 的几人的癌是过去表示的。AURKA 的 choromosome 地点, 20q13,经常在 CRC,和广泛地在大量临床的样品要调查的如此的区域需要的功能的影响被放大。colorectal 腺癌和邻近的正常上皮的匹配盒子的纸巾(n= 134 ) 在这研究被包括。量的 PCR 被执行在 CRC 检验拷贝数字和 AURKA 的 mRNA 水平。我们的结果证明 AUKRA 的拷贝数字获得在 CRC 样品的一个相对高百分比被检测(32.4% , 134 中的 43 个) 。在 AURKA 和肿瘤前进的拷贝数字增加之间有积极关联。并且 AURKA 的拷贝数字获得也在 CRC 与 mRNA 在表示上显示出积极关联。然而, AURKA mRNA 的表示水平也与未改变的拷贝数字在 CRC 样品的组被提高。这些调查结果显示分散的 colorectal 癌症展出一条规定和这可以影响的曙光的不同机制指向曙光的治疗的功效。 | Chao Zhang Zhengyu Fang Yi Xioong Jiana Li Li Liu Manhui Li Wei Zhang Jun Wan | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 4 |
| 2 | Leather for flexible multifunctional bio-based materials: a review显示文摘Nowadays, diverse leather usage conditions and increasing demands from consumers challenge the leather industry. Traditional leather manufacturing is facing long-term challenges, including low-value threshold, confined applica-tion fields, and environmental issues. Leather inherits all the biomimetic properties of natural skin such as flexibility, sanitation, cold resistance, biocompatibility, biodegradability, and other cross-domain functions, achieving unre-mitting attention in multi-functional bio-based materials. Series of researches have been devoted to creating and developing leather-based flexible multi-functional bio-materials, including antibacterial leather, conductive leather, flame-retardant leather, self-cleaning leather, aromatic leather, and electromagnetic shielding leather. In this review, we provide a comprehensive overview of the commonly used leather-based functional materials. Furthermore, the possible challenges for the development of functional leathers are proposed, and expected development directions of leather-based functional materials are discussed. This review may promote and inspire the emerging preparation and applications of leather for flexible functional bio-based materials. | Zhongxue Bai Xuechuan Wang Manhui Zheng Ouyang Yue Long Xie Siyu Zha Shuyin Dong Tong Li Yanyan Song Mengchen Huang Xinhua Liu | 2022 | Journal of Leather Science and Engineering2022，4，1： | 1 |
| 3 | Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells显示文摘Nucleic acid-based systems play important roles in antiviral defense,including CRISPR/Cas that adopts RNA-guided DNA cleavage to prevent DNA phage infection and RNA interference(RNAi)that employs RNA-guided RNA cleavage to defend against RNA virus infection.Here,we report a novel type of nucleic acid-based antiviral system that exists in mouse embryonic stem cells(mESCs),which suppresses RNA virus infection by DNA-mediated RNA cleavage.We found that the viral RNA of encephalomyocarditis virus can be reverse transcribed into complementary DNA(vcDNA)by the reverse transcriptase(RTase)encoded by endogenous retrovirus-like elements in mESCs.The vcDNA is negative-sense single-stranded and forms DNA/RNA hybrid with viral RNA.The viral RNA in the heteroduplex is subsequently destroyed by cellular RNase H1,leading to robust suppression of viral growth. | Junyu Wu Chunyan Wu Fan Xing Liu Cao Weijie Zeng Liping Guo Ping Li Yongheng Zhong Hualian Jiang Manhui Luo Guang Shi Lang Bu Yanxi Ji Panpan Hou Hong Peng Junjiu Huang Chunmei Li Deyin Guo | 2021 | Cell Research2021，31，9： | 0 |
| 4 | Functional expression of cystic fibrosis transmembrane conductance regulator in rat oviduct epithelium显示文摘这研究的目的是在老鼠输卵管上皮与 electrophysiological 和分子的技术调查膀胱的纤维变性 transmembrane 传导力管理者(CFTR ) 的功能的表示。在整个房间的补丁夹钳,上皮的房间在没有差距的模式在里面的电流与上升对 100 M 8-bromo-adenosine 3,5-cyclic monophosphate ( 8-Br-cAMP )作出回应的输卵管,它被 5 M CFTR ( inh )-172,连续地禁止一个 CFTR 特定的禁止者,和 1 公里 diphenylamine-2-carboxylate ( DPC ), Cl -隧道 blocker 。激活营地的水流展出了一线性当前电压(I-V ) 关系和时间无关、电压无关的特征。在对称的 Cl - 答案的激活营地的水流的颠倒潜力接近了 Cl - 平衡, 0.5 湩愠獮敷 ? 潴吗? | Minhui Chen Jianyang Du Weijian Jiang Wulin Zuo Fang Wang Manhui Li Zhongluan Wu Hsiaochang Chan Wenliang Zhou | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 0 |
| 5 | Suppression of UsP8 sensitizes cells to ferroptosis via SQSTM1/p62-mediated ferritinophagy显示文摘Dear Editor,Ferroptosis is a newly discovered form of regulated cell death characterized by increased intracellular iron accumulation and subsequent lipid peroxidation(Dixon et al.,2012).Studies have revealed that ferroptosis plays an important role in multiple physiological and pathological processes including degenerative diseases,carcinogenesis,and cancer immunotherapy(Hassannia et al.,2019,Wang et al.,2019). | Lihong Liu Birong Zheng Manhui Luo Jie Du Fang Yang Chuanxin Huang Zengyi Ma Chunmei Li Deyin Guo Hong Peng | 2023 | Protein & Cell2023，14，3： | 0 |
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