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| 1 | Mutation profile and its correlation with clinicopathology in Chinese hepatocellular carcinoma patients显示文摘Background:Hepatocellular carcinoma(HCC)is one of the most common causes of cancer worldwide.Although many studies have focused on oncogene characteristics,the genomic landscape of Chinese HCC patients has not been fully clarified.Methods:A total of 165 HCC patients,including 146 males and 19 females,were enrolled.The median age was 55 years(range,27-78 years).Corresponding clinical and pathological information was collected for further analysis.A total of 168 tumor tissues from these patients were selected for next-generation sequencing(NGS)-based 450 panel gene sequencing.Genomic alterations including single nucleotide variations(SNV),short and long insertions and deletions(InDels),copy number variations,and gene rearrangements were analyzed.Tumor mutational burden(TMB)was measured by an algorithm developed in-house.The top quartile of HCC was classified as TMB high.Results:A total of 1,004 genomic alterations were detected from 258 genes in 168 HCC tissues.TMB values were identified in 160 HCC specimens,with a median TMB of 5.4 Muts/Mb(range,0-28.4 Muts/Mb)and a 75%TMB of 7.7 Muts/Mb.The most commonly mutated genes were TP53,TERT,CTNNB1,AXIN1,RB1,TSC2,CCND1,ARID1A,and FGF19.SNV was the most common mutation type and C:G>T:A and guanine transformation were the most common SNVs.Compared to wild-type patients,the proportion of Edmondson grade III-IV and microvascular invasion was significantly higher in TP53 mutated patients(P<0.05).The proportion of tumors invading the hepatic capsule was significantly higher in TERT mutated patients(P<0.05).The proportion of Edmondson grade I-II,alpha fetoprotein(AFP)<25μmg/L,and those without a history of hepatitis B was significantly higher in CTNNB1 mutated patients(P<0.05).CTNNB1 mutations were associated with TMB high in HCC patients(P<0.05).Based on correlation analysis,the mutation of TP53 was independently correlated with microvascular invasion(P=0.002,OR=3.096)and Edmondson grade III-IV(P=0.008,OR=2.613).The mutation of TERT was independently correlated with tumor invasion of the liver capsule(P=0.001,OR=3.030),and the mutation of CTNNB1 was independently correlated with AFP(<25μmg/L)(P=0.009,OR=3.414).Conclusions:The most frequently mutated genes of HCC patients in China were TP53,TERT,and CTNNB1,which mainly lead to the occurrence and development of HCC by regulating the P53 pathway,Wnt pathway,and telomere repair pathway.There were more patients with microvascular invasion and Edmondson III-IV grade in TP53 mutated patients and more patients with hepatic capsule invasion in TERT mutated patients,while in CTNNB1 mutated patients,there were more patients with Edmondson I-II grade,AFP<25μmg/L,and a non-hepatitis B background.Also,the TMB values were significantly higher in CTNNB1 mutated patients than in wild type patients. | Shuo Wang Huasheng Shi Tao Liu Manjiang Li Sanshun Zhou Xuan Qiu Zusen Wang Weiyu Hu Weidong Guo Xiaoqian Chen Honglin Guo Xiaoliang Shi Junping Shi Yunjin Zang Jingyu Cao Liqun Wu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 8 |
| 2 | Hierarchical Cooperative Control of Connected Vehicles:From Heterogeneous Parameters to Heterogeneous Structures显示文摘As one of the typical applications of connected vehicles(CVs),the vehicle platoon control technique has been proven to have the advantages of reducing emissions,improving traffic throughout and driving safety.In this paper,a unified hierarchical framework is designed for cooperative control of CVs with both heterogeneous model parameters and structures.By separating neighboring information interaction from local dynamics control,the proposed framework is designed to contain an upper-level observing layer and a lower-level tracking control layer,which helps address the heterogeneity in vehicle parameters and structures.Within the proposed framework,an observer is designed for following vehicles to observe the leading vehicle's states using neighboring communication,while a tracking controller is designed to track the observed leading vehicle using local feedback control.Closed-loop stability in the absence and presence of communication time delay is analyzed,and the observer is further extended to a finite time convergent one to address string stability under general communication topology.Numerical simulation and field experiment verify the effectiveness of the proposed method. | Manjiang Hu Lingkun Bu Yougang Bian Hongmao Qin Ning Sun Dongpu Cao Zhihua Zhong | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，9： | 1 |
| 3 | Design and Occupant-Protection Performance Analysis of a New Tubular Driver Airbag显示文摘 | Huajian Zhou Zhihua Zhong Manjiang Hu | 2018 | Engineering2018，4，2： | 1 |
| 4 | Preface for Cyber‑Attack Detection and Resilient Control of Intelligent and Connected Vehicles显示文摘Intelligent and connected vehicles(ICVs),as a critical future product of the automotive industry,have developed rapidly in recent years.The insertion of a cyber chain between vehicles can bring considerable benefits,including shared perception information,improved traffic efficiency,enhanced vehicle safety,optimized energy utilization,and reduced carbon emissions. | Hui Zhang Manjiang Hu Anh‑Tu Nguyen Yunpeng Wang Yang Shi | 2023 | Automotive Innovation2023，6，2： | 0 |
| 5 | Trajectory tracking control of autonomous heavy-duty mining dump trucks with uncertain dynamic characteristics显示文摘The proportion of mines using autonomous mining trucks is still very low at present.To promote the development of intelligent mining,it is urgent to proceed with the drive-by-wire modification to common mining trucks and design a motion control algorithm considering uncertain dynamic characteristics.This paper proposes a trajectory tracking control method for autonomous heavy-duty mining dump trucks(AHMDTs)with uncertain dynamic characteristics.In this method,a driving/braking force compensation algorithm based on an inverse dynamic model is designed to guarantee accurate longitudinal control with less control gain tuning.Using road curvatures,a modified rear-wheel position feedback control method is proposed to deal with reverse-path tracking,which can simultaneously reduce the lateral error and yaw angle error.A modified Stanley controller considering the collaborative preview based on speed and curvature is constructed to achieve accurate path tracking in the forward gear.Moreover,the proposed method focuses on the practice of trajectory tracking control in an open-pit mine condition with the adverse effects caused by uncertain vehicle dynamics,huge variable load,and large actuator lag.Real vehicle tests show that the proposed methodology can control AHMDTs with a low tracking error. | Liang CHEN Zhaobo QIN Manjiang HU Hongbo GAO Yougang BIAN Biao XU Xiaoyan PENG | 2023 | Science China(Information Sciences)2023，66，10： | 0 |
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