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| 1 | Stimulus-responsive room temperature phosphorescence in purely organic luminogens显示文摘Luminogens that exhibit stimulus-responsive room temperature phosphorescence(RTP)have attracted significant attention for their applications in a wide range of fields such as data storage,sensors,and bio-imaging.However,very few such materials are known,partly because of the unclear internal mechanism.In this review,we summarize recent advances in the field of stimulusresponsive RTP in purely organic luminogens,focusing on their unique emission behaviors and internal mechanisms governing the phenomena.We also attempt to identify the relationship between the mechanism,luminogens,and possible applications. | Jie Yang Manman Fang Zhen Li | 2020 | InfoMat2020，2，5： | 10 |
| 2 | A new choice of stent for transjugular intrahepatic portosystemic shunt creation: Viabahn ePTFE covered stent/bare metal stent combination显示文摘Objectives:To compare the clinical outcomes in terms of structure and function between the insertion of a transjugular intrahepatic portosystemic shunt(TIPS) created with the Viabahn ePTFE covered stent/bare metal stent(BMS) combination and the Fluency ePTFE covered stent/BMS combination.Methods:A total of 101 consecutive patients who received a TIPS from February 2016 to August 2018 in our center were retrospectively analyzed.Sixty-four subjects were enrolled in the Viabahn group and 37 were enrolled in the Fluency group.The geometry characteristics of the TIPS were calculated,and the associated occurrence of shunt dysfunction,survival,overt hepatic encephalopathy,and variceal rebleeding were evaluated.Results:The technical success rate was 100%.After the insertion of the TIPS,the rate of shunt dysfunction during the first 3 months was significantly different between the Viabahn and Fluency groups(1.6% and 13.5%,respectively;p=0.024).Multivariate analysis indicated that the angle of portal venous inflow(α) was the only independent risk factor for shunt dysfunction(hazard ratio=1.060,95% confidence interval=1.009-1.112,p=0.020).In addition,3 months after the TIPS insertion,the a angle distinctly increased from 20.9°±14.3°-26.9°±20.1°(p=0.005) in the Fluency group but did not change significantly in the Viabahn group(from 21.9°±15.1°-22.9°± 17.6°,p=0.798).Conclusions:Shunt dysfunction was related to the a angle owing to the slight effect on the a angle after the implantation of the TIPS.The Viabahn ePTFE covered stent/BMS combination was more stable in structure and promised higher short-term stent patency compared with the Fluency ePTFE covered stent/BMS combination. | Jiacheng Liu Jie Meng Chen Zhou Qin Shi Chongtu Yang Jinqiang Ma Manman Chen Bin Xiong | 2021 | Journal of Interventional Medicine2021，4，1： | 9 |
| 3 | Host–guest materials with room temperature phosphorescence:Tunable emission color and thermal printing patterns显示文摘The research of purely organic materials with long afterglow has drawn more and more attention,especially for those with stimulus‐response characteristic.So far,this kind of material is really very scarce and their performance is not good enough.In this study,we successfully developed an efficient heatingresponsive room‐temperature phosphorescence material with phosphorescence efficiency and lifetime up to 13.4%and 2.08 s through the simple host–guest doping strategy.Further on,by introducing the additional energy acceptor of fluorescein with concentration‐dependent emission to construct ternary doping systems,the afterglow color was extended from blue to yellow.Accordingly,the multicolor thermal printings have been easily realized,showing the great practical application prospects. | Yunsheng Wang Jie Yang Yanxiang Gong Manman Fang Zhen Li Ben Zhong Tang | 2020 | SmartMat2020，1，1： | 8 |
| 4 | Pharmacokinetics of H002, a novel S1PR_1 modulator, and its metabolites in rat blood using liquid chromatography–tandem mass spectrometry显示文摘A rapid and sensitive liquid chromatography–tandem mass spectrometry(LC–MS/MS) method was developed and validated for the simultaneous determination of H002 and its phosphorylated metabolite, H002-P and hydroxylated metabolite H002-M, in rat blood. H001, an analogue of H002, was used as the internal standard.Blood samples were prepared by simple protein precipitation. The analytes and internal standard were separated on a Zorbax SB-C18 column with a gradient mobile phase consisting of methanol and water containing 0.1% formic acid at a flow rate of 0.2 mL /min with an operating temperature of 20 1C. The detection was performed on a triple quadrupole tandem mass spectrometer with positive electrospray ionization in multiple-reaction monitoring mode.Linear detection responses were obtained from 0.2–100 ng/mL for H002 and H002-M, while 0.5–100 ng/mL for H002-P. The intra- and inter-day precision(RSD%) was within 11.76%, with the accuracy(RE%) ranging from –9.84% to 9.12%. The analytes were shown to be stable during sample storage, preparation and analytic procedures.The method was applied to determine the pharmacokinetics of H002 in rats, and a preliminary study showed that the pharmacokinetics of H002 correlated with its biological effect on peripheral blood lymphocytes. | Jiaqi Mi Manman Zhao Shu Yang Shuang Yang Jing Jin Xiaojian Wang Qiong Xiao Jinping Hu Yan Li | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 5 |
| 5 | Stimulus-Responsive Room Temperature Phosphorescence Materials:Internal Mechanism,Design Strategy,and Potential Application显示文摘CONSPECTUS:Room temperature phosphorescence(RTP)materials,which could respond to external stimuli,such as force,heat,light,electric filed,etc.,have drawn increasing attention for their broad application prospects,especially in the fields of anticounterfeiting,sensors,data storage,and so on.In comparison with the traditional fluorescence ones,RTP materials show much longer emission lifetimes,which can be even caught by the naked eye.Thus,the change in emission lifetime under an external stimulus for RTP materials can be also a potential monitoring parameter,in addition to emission color and intensity.In other words,the number of visual monitoring parameters could increase from two to three in RTP materials,which would greatly facilitate their practical applications.Until now,RTP materials have been typically limited to metal-containing inorganic materials,particularly rare-earth phosphors.Their emissions are governed by the slow liberation of trapped charge carriers from isolated traps of impurities,defects,or ions through thermal stimulation with low luminescence efficiency.However,these materials suffer from some intrinsic disadvantages,including high cost,potential toxicity,and instability in aqueous environments.In order to solve these problems,the purely organic RTP materials should be a good choice.However,these kinds of materials are really scarce now,especially for the ones with stimulus response characteristic.To develop purely organic RTP materials with a stimulus response effect,we and other scientists have tried a lot.Luckily,some progresses have been made.In this Account,we present our recent progress on the stimulus-responsive room temperature phosphorescence of organic materials,mainly focusing on the internal mechanism and potential applications.First,the fundamental knowledge is described to illustrate the importance and main principles of the stimulus-responsive RTP effect.Then,some typical stimulus-responsive RTP materials based on different internal mechanisms are discussed.Mainly,two kinds of stimulus-responsive RTP materials were introduced,namely,single-component and multicomponent ones.Correspondingly,their dynamic change of the RTP property under external stimulus occurred based on the distinct internal mechanisms.For single-component materials,the changes in molecular structure,packing,or conformation,have played a significant role in their corresponding stimulus-responsive RTP effect.As for multicomponent materials,the changed oxygen concentration in matrix and intermolecular distance between different components were found more during the stimulus-responsive RTP process.Accordingly,different potential applications were explored based on the different stimulus-responsive RTP processes.With the classification of stimulus-responsive RTP materials based on different internal mechanisms,the corresponding design strategy could be well proposed,thus guiding the further development of this research field. | Jie Yang Manman Fang Zhen Li | 2021 | Accounts of Materials Research2021，2，8： | 3 |
| 6 | AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells显示文摘X chromosome inactivation and genomic imprinting are two classic epigenetic regulatory processes that cause mono-allelic gene expression.In female mammals,mono-allelic expression of the long non-coding RNA gene X-inactive specific transcript(XIST)is essential for initiation of X chromosome inactivation upon differentiation.We have previously demonstrated that the central factor of super elongation complex-like 3(SEC-L3),AFF3,is enriched at gamete differentially methylated regions(DMRs)of the imprinted loci and regulates the imprinted gene expression.Here,we found that AFF3 can also bind to the DMR downstream of the XIST promoter.Knockdown of AFF3 leads to de-repression of the inactive allele of X IST in terminally differentiated cells.In addition,the binding of AFF3 to the XIST DMR relies on DNA methylation and also regulates DNA methylation level at DMR region.However,the KAP1-H3K9 methylation machineries,which regulate the imprinted loci,might not play major roles in maintaining the mono-aUelic expression pattern of XIST in these cells.Thus,our results suggest that the differential mechanisms involved in the X IST DMR and gDMR regulation,which both require AFF3 and DNA methylation. | Yue Zhang Chao Wang Xiaoxu Liu Qian Yang Hongliang Ji Mengjun Yang Manman Xu Yunyan Zhou Wei Xie Zhuojuan Luo Chengqi Lin | 2019 | Journal of Molecular Cell Biology2019，11，9： | 3 |
| 7 | Interlayer coupling in anisotropic/isotropic van der Waals heterostructures of ReS2 and MoS2 monolayers显示文摘在里面飞机对称是到二维的分层的材料,以及原子地薄的异质接面的物理性质的一个重要贡献者。这里,在夹层联合相互作用和费用分离被观察由的地方,我们表明物件 2 和瞬间 2 单层的各向异性 / 各向同性的货车 der Waals (vdW ) heterostructures 在 situ Raman 光致发光光谱学,电,并且 photoelectrical 大小。我们相信这些结果能对理解原子地薄的 vdW heterostructures 的基本物理并且创造电子的小说和 optoelectronic 设备有用。 | Mei Zhao Wenting Zhang Manman Liu Chao Zou Keqin Yang Yun Yang Youqing Dong Lijie Zhang Shaoming Huang | 2016 | Nano Research2016，9，12： | 3 |
| 8 | A review of systematic evaluation and improvement in the big data environment显示文摘The era of big data brings unprecedented opportunities and challenges to management research.As one of the important functions of management decision-making,evaluation has been given more functions and application space.Exploring the applicable evaluation methods in the big data environment has become an important subject of research.The purpose of this paper is to provide an overview and discussion of systematic evaluation and improvement in the big data environment.We first review the evaluation methods based on the main analytic techniques of big data such as data mining,statistical methods,optimization and simulation,and deep learning.Focused on the characteristics of big data(association feature,data loss,data noise,and visualization),the relevant evaluation methods are given.Furthermore,we explore the systematic improvement studies and application fields.Finally,we analyze the new application areas of evaluation methods and give the future directions of evaluation method research in a big data environment from six aspects.We hope our research could provide meaningful insights for subsequent research. | Feng YANG Manman WANG | 2020 | Frontiers of Engineering Management2020，7，1： | 3 |
| 9 | The initial attempt to reveal the emission processes of both mechanoluminescence and room temperature phosphorescence with the aid of circular dichroism in solid state显示文摘A phenothiazine derivative PtzChol containing non-conjugated chiral cholesterol group was designed and synthesized. By analyzing the single crystal structure of PtzChol carefully, coupled with the circular dichroism(CD) signals before and after grinding, it was found that the introduction of cholesterol produced a positive effect on the production of chiral space group, on mechanoluminescence(ML) and room temperature phosphorescence(RTP), and throughout the entire light-emitting process, the CD signal could well reflect the changes of molecular arrangement. | Yu Tian Xuekang Yang Yanbin Gong Yunsheng Wang Manman Fang Jie Yang Zhiyong Tang Zhen Li | 2021 | Science China Chemistry2021，64，3： | 2 |
| 10 | Organic luminescent materials:The concentration on aggregates from aggregation-induced emission显示文摘The research of organic luminescent materials in aggregate has drawn more and more attention for their wide applications.To adjust the luminescent properties for aggregates,a deep understanding of the corresponding internal mechanism is needed.In this short review,a brief introduction of aggregation-induced emission(AIE)and some other solid state luminescence behaviors derived from or parallel to AIE is presented.Particularly,the relationship between emission property and intermolecular/intramolecular interactions is summarized,with the aim to guide the further development of organic optoelectronic materials in aggregate. | Jie Yang Manman Fang Zhen Li | 2020 | Aggregate2020，1，1： | 2 |
| 11 | The equal-efficiency-proving of fluorescence quenching and enhancement equation显示文摘Through the fluorescence and ultraviolet- visible spectrophotometry we have studied the action of ce- foperazone sodium and worfloxacin, two kinds of medicine with albumin, and examined the equal efficiency quality of fluorescence enhancement and fluorescence quenching equa- tion. The result shows the equal efficiency of calculating dis- sociation constant. In this article, we obtain the dissociation constants of the action of the two kinds of medicine with bo- vine serum albumin, energy- transfer efficiency, the distance of donor-acceptor and quenching constants. The above shows that the action is not caused by dynamic collision but by the binding of medicine and albumin. This article specially points out that the [Mt]/[Pt], which is the ratio of the maxi- mum mol concentration of the quenching agent (medicine) to fluorescent (albumin) mol concentration when the quenching ends, is very important because it is the maximum binding number of quenching agent molecule to a fluorescent mole- cule. There is no more quenching after adding more quench- ing agent beyond this quantity to fluorescent solution. This quantity is determined directly and strictly by experiment, so is also of important significance when discussing quenching efficiency and binding situation of donor-acceptor. | YANG Manman XI Xiaoli YANG Pin | 2005 | Chinese Science Bulletin2005，50，22： | 2 |
| 12 | Endpoint detection of noisy speech using empirical mode decomposition显示文摘 | Li Manman Yang Hongwu Guo Weitong | 2012 | International Journal of Digital Content Technology and Its Application2012，6，10： | 1 |
| 13 | Study on the binding mode of Mg(Sal_2trien) with DNA显示文摘In this study the complex Mg(Sal2trien) was synthesized for the first time, the binding mode of which with CT DNA was studied by the methods of UV spectra, fluorescence spectra, viscosity and CV (cyclic voltammetry). It was found that after the com- plex acted with CT DNA, the Abs of UV spectra rose obviously; the fluorescence intensity of EB-DNA was almost not changed; viscosity decreased. Determina- tion of cyclic voltammetry showed that DNA made the MgL’s formal potential negatively shift. Scatchard plot showed that the addition of the binding mode of the complex to EB was uncompetitive inhibition com- pared with EB to DNA. So the binding mode of the complex with CT DNA was stable-electricity binding. Then the interaction of the complex with pBR322 was studied by the method of gel electrophoresis. The result showed that the complex could cleave pBR322 DNA effectively. | XI Xiaoli YANG Manman ZHOU Chengyong ZHAO Jing YANG Pin | 2006 | Chinese Science Bulletin2006，51，19： | 1 |
| 14 | Actin-depolymerizing factor of sec- ond-generation merozoite in Eimeria tenella : clone, pro- karyotic expression and dlclazuril-induced mRNA ex- pression显示文摘 | Bianhua Zhou Hongwei Wang Feiqun Xue Xiaoyang Wang Fengkun Yang Manman Ban Ruixiang Xin Congcong Wang | 2010 | Parasitology Research2010，，106： | 1 |
| 15 | A Highly Efficient and Selective Water-Soluble Bimetallic Catalyst for Hydrogenation of Chloronitrobenzene to Chloroaniline显示文摘Selective hydrogenation of chloronitrobenzene(CNB) to chloroaniline(CAN) catalyzed by water-soluble Ru/Pt bimetallic catalyst in an aqueous-organic biphasic system was studied. It was found that the catalytic activity increased obviously due to the addition of platinum. Ru/Pt bimetallic catalysts exhibited a strong synergistic effect when the molar ratio of Pt was in the range of 5%—80%. Under the mild conditions including a temperature of 25 ℃, a hydrogen pressure of 1.0 MPa and a Pt molar ratio of 20%, the conversion of p-chloronitrobenzene(p-CNB) reached 99.9%, with the selectivity to p-chloroaniline(p-CAN) equating to 99.4%. The Ru/Pt catalyst also showed high activity and selectivity for the hydrogenation of other chloro- and dichloro-nitrobenzenes with different substituted positions. In addition, the catalyst can be recycled five times without significant loss of activity. | Zhou Yafen Yang Wenjuan Zhou Limei Wang Manman Ma Xiaoyan | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，2： | 1 |
| 16 | Experimental study on advantages of foam–sol in coal dust control显示文摘 | Zhilin Xi Manman Jiang Jinjun Yang Xian Tu | 2013 | Process Safety and Environmental Protection2013，，： | 1 |
| 17 | In situ fabrication of Na3V2(PO4)3 quantum dots in hard carbon nanosheets by using lignocelluloses for sodium ion batteries显示文摘The rational assembly of quantum dots on two-dimensional(2 D) carbonaceous materials is very promising to produce materials, but remains a challenge. Here, we develop an assembly strategy of growing Na3 V2(PO4)3 quantum dots with superlattice structure(NVP-QDs-SL) for obtaining precise control of the size, distribution and crystallinity. The multifunctional lignocelluloses(LCs) used as a hard carbon source induce heterogeneous nucleation and confined growth of NVP-QDs-SL, leading to the uniform distribution of NVP-QDs-SL in H/S-doped hard carbon ultra-thin nanosheets(HCS). Detailed electrochemical analysis results from sodium-ion batteries of NVP-QDs-SL show that NVP-QDs-SL could trap the electrons inside HCS, significantly enhancing Na ion storage and transfer kinetics. Compared to the common Na3 V2(PO4)3 nanoparticle cathode, the NVP-QDs-SL/HCS cathode exhibits a high reversible capacity of 149.2 m A h g^-1 at a 0.1 C rate, which is far beyond the theoretical capacity of Na3 V2(PO4)3(117.6 m A h g^-1).At the ultrahigh current rate of 100 C, this cathode still remains a high discharge capacity of 40 m A h g-1.Even after cycling at 20 C over 3000 cycles, an ultrahigh coulombic efficiency close to 100% is still obtained,highlighting its excellent long cycling life, remarkable rate performance and energy density. | Qihao Zhang Xudong Zhang Wen He Guogang Xu Manman Ren Jinhua Liu Xuena Yang Feng Wang | 2019 | Journal of Materials Science & Technology2019，35，10： | 1 |
| 18 | Altering membrane structure to enhance water permeability and performance of anion exchange membrane fuel cell显示文摘Water management has been proven significant for enhancing both performance and durability of anion exchange membrane fuel cell. Besides searching new material, decreasing membrane thickness and modifying operation parameters, a simple and universal method of altering membrane structure is proposed in this work. Composite membranes made by unique processing method that includes both casting and electrospinning processes were compared with traditional casting membrane, all with the same thickness of 40 μm. Comparing to traditional casting membrane, the composite membrane put at proper position shows a higher water permeability, thus even more than 50% enhancement of the peak performance. | YANG Yue GAO XueQiang SONG Wei YU HongMei LI WenBin QI ManMan HUANG He WANG PengHao FAN ZhiXuan SHAO ZhiGang | 2021 | Science China(Technological Sciences)2021，64，2： | 1 |
| 19 | Chromatographic characterization and solid-phase extraction on diniconazole-imprinted polymers stationary phase显示文摘 | Yang Gengliang Liu FIaiyan Wang Manman | 2006 | Rea Funct Polym2006，66，5： | 1 |
| 20 | OShnscc:a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information显示文摘Head and neck squamous cell carcinoma(HNSCC),as the most common type(>90%)of head and neck cancer,includes various epithelial malignancies that arise in the nasal cavity,oral cavity,pharynx,and larynx.In 2020,approximately 878000 new cases and 444000 deaths linked to HNSCC occurred worldwide(Sung et al.,2021).Due to the associated frequent recurrence and metastasis. | Guosen ZHANG Qiang WANG Xinlei QI Huimin YANG Xiaodong SU Manman YANG Chao JIANG Yang AN Hong Zheng LU Zhang Wan ZHU Jiancheng GUO Xiangqian GUO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，3： | 1 |
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