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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | The tumor necrosis factor alpha-stimulation region of galactose-inhibitable letin of Entamoeba histolytica activities interferon-primed macrophages for amebicidal activity mediated by nitric oxide显示文摘 | Seguin R Mann BJ Keller K | | Infection and Immunity0，，： | 2 |
| 3 | Hyperhomocysteinemia and the prevalence of atherosclerotic vascular disease in patients with endstage renal disease显示文摘 | Manns BJ Burgges ED Hyndman ME | | 0，，06： | 1 |
| 4 | Reviewing the reviewers:the quality of reporting in three secondary journals显示文摘 | Devereaux PJ Manns BJ Ghali WA | | 0，，11： | 1 |
| 5 | Association betweenmultidisciplinary care and survival for elderly patients with chronickidney disease 显示文摘 | Hemmelgam BR Manns BJ Zhang J | 2007 | J Am Soc Nephrol2007，18，3： | 1 |
| 6 | The effect ofnocturnal and conventional hemodialysis on markers ofnutritional status: results from a randomized trial显示文摘 | Schorr M Manns BJ Culleton B | 2010 | JRen Nutr2010，4，4： | 1 |
| 7 | Impact of anemia on hospitalization and mortality in older adults 显示文摘 | Culleton BF Manns BJ Zhang J | 2006 | Blood2006，107，10： | 1 |
| 8 | Hyperhomocysteinemia and the prevalence of atherosclerotic vascular disease in patients with endstage renal disease 显示文摘 | Manns BJ Burgges ED Hyndman ME | 2002 | Am J Kidney Dis2002，43，6： | 1 |
| 9 | Dialysis adequacyand health related quality of life in hemodialysispatients显示文摘 | Manns BJ Johnson JA Taub K | 2002 | ASA10 J2002，48，： | 1 |
| 10 | A survey of sports medicine physicians regarding psychological issues in patient- athletes 显示文摘 | Mann BJ Grana WA Indelicato PA | 2007 | Am J Sports Med2007，35，12： | 1 |
| 11 | An economic evaluation of operative compared with nonoperative management of displaced intra-articular calcaneal fractures显示文摘 | Brauer CA Manns BJ Ko M | 2005 | J Bone Joint Surg Am2005，87，： | 1 |
| 12 | Relation betweenkidney function, proteinuria, and adverse outcomes 显示文摘 | Hemmelgarn BR Manns BJ Lloyd A | 2010 | JA-MA2010，303，5： | 1 |
| 13 | Indications for and Outcomes After Combined Lung and Liver Transplantation: A Single-Center Experience on 13 Consecutive Cases显示文摘 | Gerrit Grannas Michael Neipp Marius M. Hoeper Jens Gottlieb Rainer Lück Thomas Becker Andre Simon Christian P. Strassburg Michael P. Manns Tobias Welte Axel Haverich Jürgen Klempnauer Bj?rn Nashan Martin Strueber | 2008 | Transplantation2008，，4： | 1 |
| 14 | Relation between kid- ney function, proteinuria, and adverse outcomes显示文摘 | Hemmelgarn BR Manns BJ Lloyd A | 2010 | JAMA2010，303，5： | 1 |
| 15 | Relation between kidney function, proteinuria, and adverse outcomes显示文摘 | Hemmelgarn BR Manns BJ Lloyd A | 2010 | JAMA2010，303，5： | 1 |
| 16 | An economic evaluation of operativecompared with nonoperative management of displaced intra-articularcalcaneal fractures显示文摘 | Brauer CA Manns BJ Ko M | 2005 | J Bone Joint Surg (Br)2005，87，12： | 1 |
| 17 | An economicevaluation of rt-PA locking solution in dialysis catheters 显示文摘 | Manns BJ Scott-Douglas N Tonelli M et a\ | 2014 | JAm Soc Nephrol2014，25，12： | 1 |
| 18 | Hyperhomocysteinemia and the prevalence of atherosclerotic vascular disease in patients with end-stage renal disease显示文摘 | Burgess ED Hyndman ME | 1999 | Am J Kidney Dis1999，34，4： | 1 |
| 19 | Experimental intervertebral discolysis显示文摘 | Mann M | 1971 | Clin orthop1971，80，： | 1 |
| 20 | An economic evaluation of operative compared with nonoperative management of displaced intra-articular calcaneal fractures显示文摘 | Brauer CA Manns BJ Ko M | 2005 | Bone Joint Surg2005，87，12： | 1 |
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