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| 1 | Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals:From experimental models to clinical trials显示文摘Chemoprevention is one of the cancer prevention approaches wherein natural/synthetic agent(s) are prescribed with the aim to delay or disrupt multiple pathways and processes involved at multiple steps, i.e., initiation, promotion, and progression of cancer. Amongst environmental chemopreventive compounds, diet/beverage-derived components are under evaluation, because of their long history of exposure to humans, high tolerability, low toxicity, and reported biological activities. This compilation briefly covers and compares the available evidence on chemopreventive efficacy and probable mechanism of chemoprevention by selected dietary phytochemicals(capsaicin, curcumin, diallyl sulphide, genistein, green/black tea polyphenols, indoles, lycopene, phenethyl isocyanate, resveratrol, retinoids and tocopherols) in experimental systems and clinical trials. All the dietary phytochemicals covered in this review have demonstrated chemopreventive efficacy against spontaneous or carcinogen-induced experimental tumors and/or associated biomarkers and processes in rodents at several organ sites. The observed anti-initiating, anti-promoting and anti-progression activity of dietary phytochemicals in carcinogen-induced experimental models involve phytochemical-mediated redox changes, modulation of enzymes and signaling kinases resulting to effects on multiple genes and cell signaling pathways. Results from clinical trials using these compounds have not shown them to be chemopreventive. This may be due to our:(1) inability to reproduce the exposure conditions, i.e., levels, complexity, other host and lifestyle factors; and(2) lack of understanding about the mechanisms of action and agent-mediated toxicity in several organs and physiological processes in the host. Current research efforts in addressing the issues of exposure conditions, bioavailability, toxicity and the mode of action of dietary phytochemicals may help address the reason for observed mismatch that may ultimately lead to identification of new chemopreventive agents for protection against broad spectrum of exposures. | Girish B Maru Rasika R Hudlikar Gaurav Kumar Khushboo Gandhi Manoj B Mahimkar | 2016 | World Journal of Biological Chemistry2016，7，1： | 2 |
| 2 | Investigation of nanocrystalline structure in selected carbonaceous materials显示文摘九印度煤的结构的参数被 X 光检查衍射(XRD ) 和拉曼光谱学决定。学习表明煤与非结晶的碳包含 turbostratic 结构的水晶的碳。叠的高度(L < 潜水艇 class= “ a-plus-plus ” > c ) 和夹层间距(d < 潜水艇 class= “ a-plus-plus ” > 煤的雏晶结构的 002 ) 分别地从 1.986 ~ 2.373 nm 并且从 0.334 ~ 0.340 nm 。graphitization 的度被计算从 42% ~ 99%,从而证实随煤的增加订碳层等级。指数的关联在 aromaticity 之中被观察( f <潜水艇class=“ a-plus-plus ”>),侧面的尺寸( L <潜水艇class=“ a-plus-plus ”>),和等级(我<潜水艇class=“ a-plus-plus ”> 20 /I <潜水艇class=“ a-plus-plus ”> 26 ),建议煤雏晶是在自然的 nanocrystalline 。很强壮的关联在结构的参数之间被观察( f <潜水艇class=“ a-plus-plus ”>, d <潜水艇class=“ a-plus-plus ”> 002 , L <潜水艇class=“ a-plus-plus ”> c , H/C 比率,并且我<潜水艇class=“ a-plus-plus ”> 20 /I <潜水艇class=“ a-plus-plus ”> 26 ),不稳定的事内容,和元素的碳满足,显示煤的结构被接触变态的度控制。拉曼系列展出了二个突出的乐队:graphitic 乐队(G) 和一阶的典型缺点乐队(D) 。deconvolution 导致了五座山峰:G, D1, D2, D3,和 D4。强烈 D1 乐队,出现在 1350 厘米,啜 class= “ a-plus-plus ” > 1 , 与 A 对应于一个格子颤动模式 < 潜水艇 class= “ a-plus-plus ” > 1g 对称。D2 模式,出现在 1610 厘米,啜 class= “ a-plus-plus ” > 1 , 在 G 乐队上作为一个肩膀从结构的混乱产生。 | Manoj B | 2014 | International Journal of Minerals,Metallurgy and Materials2014，21，9： | 2 |
| 3 | Naph- thalimide appended rhodamine derivative: through bond energy transfer for sensing of Hg^2+ ions 显示文摘 | MANOJ K NARESH K VANDANA B | 2011 | Org Lett2011，13，6： | 1 |
| 4 | Decay and half-life period of online citations cited in open access journals 显示文摘 | Sampath Kumar B Manoj Kumar K | 2012 | The International Information&Library Review2012，，： | 1 |
| 5 | Mechanisms of material removal during high temperature fretting of TiCN-Ni based cermets显示文摘 | MANOJ KUMAR B V BASU B | 2008 | International Journal of Refractory Metals and Hard Materials2008，26，6： | 1 |
| 6 | Cra- ter wear mechanisms of Ti(C, N)-Ni-WC cermets during dry machining 显示文摘 | Manoj Kumar B V Ram Kumar J Basu Bikramjit | 2007 | International Journal of Refractory Metals & Hard Materials2007，25，5： | 1 |
| 7 | P2P Networking:An Information Sharing Alternative显示文摘 | Manoj Parameswaran Anjana Susarla Andrew B Whinston | 2001 | Computer2001，34，7： | 1 |
| 8 | An incidental persistent falcine sinus with dominant straight sinus and hypoplastic superior sagital sinus 显示文摘 | Manoj KS Krishnamoorthy T Thomas B | 2006 | Pediatr Radiol2006，36，： | 1 |
| 9 | Development of a SYBR Green based real-time PCR assay for detection and quantitation of canine parvovirus in faecal samples显示文摘 | MANOJ K SUKDEB NANDI A B | 2010 | J Virol Methods2010，61，6： | 1 |
| 10 | Low-cost adsorbents from bio-waste for the removal of dyes from aqueous solution显示文摘 | Manoj Kumar Reddy P Mahammadunnisa Sk Ramaraju B | 2013 | Environ Sci Pollut Res2013，20，6： | 1 |
| 11 | Multiobjective particle swarm algorithm with fuzzy clustering for electrical power dispatch显示文摘 | Shubham Agrawal Panigrahi B K Manoj Kumar Tiwari | 2008 | IEEE Transactions on Evolutionary Computation2008，12，5： | 1 |
| 12 | Communication challenges in emergency response显示文摘 | Manoj B S Baker A H | 2007 | Communication of the ACM2007，50，： | 1 |
| 13 | Understanding the fretting wear of Ti3SiC2显示文摘 | SARKAR D MANOJ K B V BASU B | 2006 | Journal of European Ceramic Society2006，26，： | 1 |
| 14 | CogNet:a cognitivecomplete knowledge network system显示文摘 | MANOJ B S RAO R R ZORZI M | 2008 | IEEE WirelessCommunications2008，15，6： | 1 |
| 15 | Consumer comprehension of environmental advertising and labeling claims显示文摘 | Louis A Morris Manoj Hastak and Michael B Mazis | 1995 | The Journal of Consumer Affairs1995，29，2： | 1 |
| 16 | Absorption of sulfur dioxide into aqueous reactive slurries of calcium and magnesium hydroxide in a stirred cell显示文摘 | Manoj V D Antonie A C M B Vishwas G P | 2001 | Chemical Engineering Science2001，56，3： | 1 |
| 17 | Crater wear mechanisms of TiCN-Ni-WC cermets during dry machining 显示文摘 | Manoj Kumar B V Ram Kumar J Basu B | 2007 | International Journal of Refractory Metals and Hard Materials2007，25，： | 1 |
| 18 | AIEE ac- tive perylene bisimide supported mercury nanoparti- cles for synthesis of amides via aldoximes/ketoximes rearrangement显示文摘 | SANDEEP K MANOJ K VANDANA B | 2015 | Cbem Commun2015，51，19： | 1 |
| 19 | Mechanisms of Mate- rial Removal during High Temperature Fretting of TiCN- Ni Based Cermets显示文摘 | Manoj Kumar B V Bikramjit Basu | 2008 | International Journal of Refractory Metals and Hard Materials2008，26，6： | 1 |
| 20 | Natural and ge- netically engineered proteins for tissue engineering 显示文摘 | GOMES S LEONOR I B MANOJ F | 2012 | Prog Polym Sci2012，37，1： | 1 |
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