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| 1 | Measurement of wave-front aberration in soft contact lenses by use of a Shack-Hartmann wave-front sensor 显示文摘 | Tae Moon Jeong Manoj Menon Geunyong Yoon | 2005 | Applied Optics(S0003-6935)2005，44，21： | 1 |
| 2 | Listeria monocytogenes in donated platelets: a potential transfusion‐transmitted pathogen intercepted through screening显示文摘 | Manoj Menon Lewis Graves Katherine McCombs Kelly Hise Benjamin Silk Matthew Kuehnert Michael Lynch | 2013 | Transfusion2013，，9： | 1 |
| 3 | Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy显示文摘Although targeted therapies have proven effective and even curative in human leukaemia, resistance often ensues. IDH enzymes are mutated in ~20% of human AML, with targeted therapies under clinical evaluation. We here characterize leukaemia evolution from mutant IDH2 (mIDH2)-dependence to independence identifying key targetable vulnerabilities of mIDH2 leukaemia that are retained during evolution and progression from early to late stages. Mechanistically, we find that mIDH2 leukaemia are metastable and vulnerable at two distinct levels. On the one hand, they are characterized by oxidative and genotoxic stress, in spite of increased 1-carbon metabolism and glutathione levels. On the other hand, mIDH2 leukaemia display inhibition of LSD1 and a resulting transcriptional signature of all-trans retinoic acid (ATRA) sensitization, in spite of a state of suppressed ATRA signalling due to increased levels of PIN1. We further identify GSH/ROS and PIN1/LSD1 as critical nodes for leukaemia maintenance and the combination of ATRA and arsenic trioxide (ATO) as a key therapeutic modality to target these vulnerabilities. Strikingly, we demonstrate that the combination of ATRA and ATO proves to be a powerfully synergistic and effective therapy in a number of mouse and human mIDH1/2 leukemic models. Thus, our findings pave the way towards the treatment of a sizable fraction of human AMLs through targeted APL-like combinatorial therapies. | Vera Mugoni Riccardo Panella Giulia Cheloni Ming Chen Olga Pozdnyakova Dina Stroopinsky Jlenia Guarnerio Emanuele Monteleone Jonathan David Lee Lourdes Mendez Archita Venugopal Menon Jon Christopher Aster Andrew A. Lane Richard Maury Stone Ilene Galinsky José Cervera Zamora Francesco Lo-Coco Manoj Kumar Bhasin David Avigan Letizia Longo John Gerard Clohessy Pier Paolo Pandolfi | 2019 | Cell Research2019，29，6： | 1 |
| 4 | Effect of dietary fiber on the activity of intestinal and fecal beta-glucuronidase activity during 1, 2-dimethylhydrazine induced colon carcinogenesis显示文摘 | Manoj G Thampi BS Leelamma S Menon PV | 2001 | Plant Foods Hum Nutr2001，56，1： | 1 |
| 5 | Effects of heavy metal soil pollution and acid rain on growth and water use efficiency of a young model forest ecosystem显示文摘 | Manoj Menon Sandra Hermle Madeleine S. Günthardt-Goerg Rainer Schulin | 2007 | Plant and Soil (-)2007，，1： | 1 |
| 6 | Effects of heavy metal soil pollution and acid rain on growth and water use efficiency of a young model forest ecosystem显示文摘 | Manoj Menon Sandra Hermle Madeleine S. Günthardt-Goerg Rainer Schulin | 2007 | Plant and Soil (-)2007，，1： | 1 |
| 7 | The use of chitosan as a flocculant in mammalian cell culture dramatically improves clarification throughput without adversely impacting monoclonal antibody recovery显示文摘 | Frank Riske James Schroeder Julie Belliveau Xuezhen Kang Joseph Kutzko Manoj K. Menon | 2007 | Journal of Biotechnology2007，，4： | 1 |
| 8 | Measure- ment of wave-front aberration in soft contact lenses by use of a Shack - Hartmann wave-front sensor 显示文摘 | Tae Moon Jeong Manoj Menon Geunyoung Yoon | 2005 | Applied Optics2005，44，： | 1 |
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