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| 1 | Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease显示文摘MicroRNAs(miRNAs) are small non-coding RNAs that regulate multiple physiological and pathological functions through the modulation of gene expression at the post-transcriptional level. Accumulating evidence has established a role for miRNAs in the development and pathogenesis of liver disease. Specifically, a large number of studies have assessed the role of miRNAsin alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD), two diseases that share common underlying mechanisms and pathological characteristics. The purpose of the current review is to summarize and update the body of literature investigating the role of miRNAs in liver disease. In addition, the potential use of miRNAs as biomarkers and/or therapeutic targets is discussed. Among all miRNAs analyzed, miR-34 a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD. Of note, these three miRNAs have also been implicated in ALD, reinforcing a common disease mechanism between these two entities and the pleiotropic effects of specific miRNAs. Currently, no single miRNA or panel of miRNAs has been identified for the detection of, or staging of ALD or NAFLD. While promising results have been shown in murine models, no therapeutic based-miRNA agents have been developed for use in humans with liver disease. | Jorge-Luis Torres Ignacio Novo-Veleiro Laura Manzanedo Lucía Alvela-Suárez Ronald Macías Francisco-Javier Laso Miguel Marcos | 2018 | World Journal of Gastroenterology2018，24，36： | 19 |
| 2 | Biliary cystadenoma显示文摘The diagnosis of cystadenoma is rare, even more so when located in the extrahepatic bile duct.Unspeciflc clinical signs may lead this pathology to be misdiagnosed.The need for pathological anatomy in order to distinguish cystadenomas from simple biliary cysts is crucial.The most usual treatment nowadays is resection of the bile duct, together with cholecystectomy and Roux-en-Y reconstruction. | Miguel A Hernandez Bartolome Sagrario Fuerte Ruiz Israel Manzanedo Romero Beatriz Ramos Lojo Ignacio Rodriguez Prieto Luis Gimenez Alvira Rosario Granados Carreo Manuel Limones Esteban | 2009 | World Journal of Gastroenterology2009，15，28： | 4 |
| 3 | Suicidal pa- tient identification显示文摘 | Manzanedo Sagredo MI Ortiz Ferndndez MI | 2012 | Rev Enferm2012，35，1： | 1 |
| 4 | Mannosebinding lectin polymorphisms in a Canary Islands (Spain)population显示文摘 | Garcia-Laorden MI Manzanedo A Figuerola A | 2001 | Gene Immun2001，2，5： | 1 |
| 5 | Suicidal patient intification 显示文摘 | Manzanedo Sagredo MI Ortiz MI | 2012 | Rev Enferm2012，35，1： | 1 |
| 6 | The effects of dopamine D2and D3 antagonisists on spontaneous motor activity and morphine-induced hyperactivity in male mice显示文摘 | Manzanedo C Aguilar MA Minarro J | 1999 | Psychophacology(Berl)1999，143，1： | 1 |
| 7 | NMDA glutamate but not dopamine antagonists blocks drug-induced reinstence of morphine place preference显示文摘 | RIBEIRO DO COUTO B AGUILAR M A MANZANEDO C | 2005 | Brain Res Bull2005，64，6： | 1 |
| 8 | Efcts of dopamine antagonists with different receptor blockade profiles on morphine - induced place preference in male mice 显示文摘 | Manzanedo C Aguilar MA Rodriguez - Arinas M | 2001 | Behav Brain Res2001，121，12： | 1 |
| 9 | Suicidal patient identifi-cation 显示文摘 | Manzanedo Sagredo MI Ortiz Femdndez MI | 2012 | Rev Enferm2012，35，1： | 1 |
| 10 | NMDA glutamate but not dopamine antagonists blocks drug-induced reinstatement of morphine place preference 显示文摘 | RIBERIO DO CB AGUILAR MA MANZANEDO C | 2005 | Brain aes Bull2005，64，6： | 1 |
| 11 | Effects of dopamine antagonists with different receptor blockade profiles on morphine - induced place preference in male mice 显示文摘 | Manzanedo C Aguilar MA Rodriguez-Arias M | 2001 | Behav Brain Res2001，121，12： | 1 |
| 12 | The effects of dopamine D2 and D3 antagonists on spontaneous motor activity and morphine - induced hyperactivity in male mice显示文摘 | Manzanedo C Aguilar MA Minarro J | 1999 | Psychopharmacology1999，143，1： | 1 |
| 13 | Biliary cystadenoma 显示文摘 | Hemandez Bartolome MA Fuerte Ruiz S Manzanedo Romero I | 2009 | World J Gastroenterol2009，15，28： | 1 |
| 14 | Substrate specificity of arylamidase in soils 显示文摘 | Tabatabai M A Garcia- Manzanedo A M Acosta- Martinez V | 2002 | Soil Biology and Biochemistry2002，34，： | 1 |
| 15 | Suicidal pa- tient identification 显示文摘 | Manzanedo Sagredo MI Ortiz Fern6ndez MI | 2012 | Rev Enferm2012，35，1： | 1 |
| 16 | Substrate specificity of arylamidase in soils显示文摘 | Tabatabai MA García Manzanedo AM Acosta Martínez V | 2002 | Soil Biol Biochem2002，34，： | 1 |
| 17 | Experimental angiogenesis: strategy for the functional study of the transcription factors of the Ets family during morphogenesis of the vascular tree显示文摘 | Mattot V Pourtier Manzanedo A Vercamer C et al | 2000 | Ann Endocrinoi (Paris)2000，61，1： | 1 |
| 18 | Reinstatement of morphine-induced conditioned place preference in mice by priming injections显示文摘 | Do Couto BR Aguilar MA Manzanedo C Rodriguez-Arias M Minarro J | | 0，，04： | 1 |
| 19 | Suicidal patient iden- tification显示文摘 | Manzanedo Sagredo MI Ortiz Ferndndez MI | 2012 | Rev Enferm2012，35，1： | 1 |
| 20 | Effects of dopamine antagonists with different receptor blockade profiles on morphine induced place preference in male mice显示文摘 | Manzanedo C Aguilar MA Rodrigucz - Arias M | 2001 | Behav Brain Res2001，121，12： | 1 |
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