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| 1 | Accuracy of magnetic resonance cholangiography compared to operative endoscopy in detecting biliary stones, a single center experience and review of literature显示文摘AIM: To compare diagnostic sensitivity, specificity and accuracy of magnetic resonance cholangiopancreatography(MRCP) without contrast medium and endoscopic ultrasound(EUS)/endoscopic retrograde cholangiopancreatography(ERCP) for biliary calculi. METHODS: From January 2012 to December 2013, two-hundred-sixty-three patients underwent MRCP at our institution, all MRCP procedure were performed with the same machinery. In two-hundred MRCP was done for pure hepatobiliary symptoms and these patients are the subjects of this study. Among these two-hundred patients, one-hundred-eleven(55.5%) underwent ERCP after MRCP. The retrospective study design consisted in the systematic revision of all images from MRCP and EUS/ERCP performed by two radiologist with a long experience in biliary imaging, an experienced endoscopist and a senior consultant in Hepatobiliopancreatic surgery. A false positive was defined an MRCP showing calculi with no findings at EUS/ERCP; a true positive was defined as a concordance between MRCP and EUS/ERCP findings; a false negative was defined as the absence of images suggesting calculi at MRCP with calculi localization/extraction at EUS/ERCP and a true negative was defined as a patient with nocalculi at MRCP ad at least 6 mo of asymptomatic followup. Biliary tree dilatation was defined as a common bile duct diameter larger than 6 mm in a patient who had an in situ gallbladder. A third blinded radiologist who examined the MRCP and ERCP data reviewed misdiagnosed cases. Once obtained overall data on sensitivity, specificity, accuracy, positive predictive value(PPV) and negative predictive value(NPV) we divided patients in two groups composed of those having concordant MRCP and EUS/ERCP(Group A, 72 patients) and those having discordant MRCP and EUS/ERCP(Group B, 20 patients). Dataset comparisons had been made by the Student's t-test and χ2 when appropriate.RESULTS: Two-hundred patients(91 men, 109 women, mean age 67.6 years, and range 25-98 years) underwent MRCP. All patients attended regular follow-up for at least 6 mo. Morbidity and mortality related to MRCP were null. MRCP was the only exam performed in 89 patients because it did show only calculi into the gallbladder with no signs of the presence of calculi into the bile duct and symptoms resolved within a few days or after colecistectomy. The patients remained asymptomatic for at least 6 mo, and we assumed they were true negatives. One hundred eleven(53 men, 58 women, mean age 69 years, range 25-98 years) underwent ERCP following MRCP. We did not find any difference between the two groups in terms of race, age, and sex. The overall median interval between MRCP and ERCP was 9 d. In detecting biliary stones MRCP Sensitivity was 77.4%, Specificity 100% and Accuracy 80.5% with a PPV of 100% and NPV of 85%; EUS showed 95% sensitivity, 100% specificity, 95.5% accuracy with 100% PPV and 57.1% NPV. The association of EUS with ERCP performed at 100% in all the evaluated parameters. When comparing the two groups, we did not find any statistically significant difference regarding age, sex, and race. Similarly, we did not find any differences regarding the number of extracted stones: 116 stones in Group A(median 2, range 1 to 9) and 27 in Group B(median 2, range 1 to 4). When we compared the size of the extracted stones we found that the patients in Group B had significantly smaller stones: 14.16 ± 8.11 mm in Group A and 5.15 ± 2.09 mm in Group B; 95% confidence interval = 5.89-12.13, standard error = 1.577; P < 0.05. We also found that in Group B there was a significantly higher incidence of stones smaller than 5 mm: 36 in Group A and 18 in Group B, P < 0.05.CONCLUSION: Major finding of the present study is that choledocholithiasis is still under-diagnosed in MRCP. Smaller stones(< 5 mm diameter) are hardly visualized on MRCP. | Francesco A Polistina Mauro Frego Marco Bisello Emy Manzi Antonella Vardanega Bortolo Perin | 2015 | World Journal of Radiology2015，7，4： | 14 |
| 2 | Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)represents a global health problem.Infections with hepatitis B or C virus,non-alcoholic steatohepatitis disease,alcohol abuse,or dietary exposure to aflatoxin are the major risk factors to the development of this tumor.Regardless of the carcinogenic insult,HCC usually develops in a context of cirrhosis due to chronic inflammation and advanced fibrosis.Galectins are a family of evolutionarily-conserved proteins defined by at least one carbohydrate recognition domain with affinity forβ-galactosides and conserved sequence motifs.Here,we summarize the current literature implicating galectins in the pathogenesis of HCC.Expression of'proto-type'galectin-1,'chimera-type'galectin-3 and'tandem repeat-type'galectin-4 is up-regulated in HCC cells compared to their normal counterparts.On the other hand,the'tandemrepeat-type'lectins galectin-8 and galectin-9 are downregulated in tumor hepatocytes.The abnormal expression of these galectins correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,postoperative recurrence and poor prognosis.Moreover,these galectins have important roles in other pathological conditions of the liver,where chronic inflammation and/or fibrosis take place.Galectin-based therapies have been proposed to attenuate liver pathologies.Further functional studies are required to delineate the precise molecular mechanisms through which galectins contribute to HCC. | María L Bacigalupo Malena Manzi Gabriel A Rabinovich María F Troncoso | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 3 | Implentation of the ISBA parametrization scheme for land surface processes in a GCM - an annual cycle experriment显示文摘 | Manzi A O Planto S | 1994 | Journal of Hydrology1994，155，34： | 1 |
| 4 | Application of an innovative methodology to improve the starting-up of UASB reactors treating domestic sewage显示文摘 | Rodriguez J A P ena M R Manzi V | 2001 | Water Science and Technology2001，44，4： | 1 |
| 5 | Effect of smoke and clouds on the transmissivity of photosynthetically active radiation inside the canopy显示文摘 | Yamasoe M A Randow C V Manzi A O | 2006 | Atmospheric Chemistry and Physics2006，6，6： | 1 |
| 6 | 3D edge detection seismic attributes used to map potential conduits for water and methane in deep gold mines in the Witwatersrand basin, South Africa显示文摘 | Musa S D Manzi Raymond J Durrheim Kim A A Hein | 2012 | Geophysics2012，77，5： | 1 |
| 7 | Application of an innovative methodology to improve the starting-up of UASB reactors treating domestic sewage 显示文摘 | Rodriguez j A Pena M R Manzi V | 2001 | Water Science and Technology2001，44，4： | 1 |
| 8 | Intramolecular self-cleavage of polysialic acid显示文摘 | Higa H H | 1994 | J Biol Chem1994，269，23： | 1 |
| 9 | Effect of intermittent PTH administration in the periodontitis-associated bone loss in ovariectomized rats显示文摘 | MARQUES M R SILVA M A D MANZI F R | 2005 | Arch Oral Biol2005，50，4： | 1 |
| 10 | Novel fiber-reinforced composite materials based on sustainable geopolymer matrix显示文摘 | NATALI A MANZI S BIGNOZZI M C | 2011 | Procedia Engineering2011，21，： | 1 |
| 11 | Intermittent endurance and re- peated sprint ability in soccer players 显示文摘 | Chaouachi A Manzi V Wong del P Chaalali A Laurencelle L Chamari K Castagua C | 2010 | J Strength Cond Res2010，24，10： | 1 |
| 12 | A framework for ex- tremum seeking control of systems with parameter uncertainties 显示文摘 | NESIC D MOHAMMADI A MANZIE C | 2013 | IEEE Transactions on Automatic Control2013，58，2： | 1 |
| 13 | Differences in sub- clinical Cardiovascular disease between African American and Cau- casian women in systemic lupus erythematosus 显示文摘 | RHEW E Y MANZI S M DYER A R | 2009 | Transl Res2009，153，2： | 1 |
| 14 | Pharmacointeraction network models predict unknown drug-drug interactions显示文摘 | Cami A Manzi S Arnold A | 2013 | PLoS One2013，8，4： | 1 |
| 15 | A re-appraisal of Ceprano calvaria affinities with Homo erectus after the new reconstruction显示文摘 | Ascenzi A Mallegni F Manzi G | 2000 | Journal of Human Evolution2000，39，： | 1 |
| 16 | Quantitative monosaccharide analysis : A multi-center study显示文摘 | Townsend R R Manzi A Merkle R K | 1997 | ABRFNews1997，8，： | 1 |
| 17 | High-pressure liquid chromatography of sialic acids on a pellicular resin anionexchange column with pulsed amperometric显示文摘 | Diaz S Varki A | 1990 | Anal Biochem1990，188，： | 1 |
| 18 | Commercial mushrooms : nutritional quality and effect of cooking 显示文摘 | Manzi P Marconi S Aguzzi A | 2004 | Food Chemistry2004，84，： | 1 |
| 19 | Overview of glycoconjugate analysis 显示文摘 | Varki A Freeze I-IH Manzi AE | 2009 | Curr Protoc Protein Sci2009，，8： | 1 |
| 20 | Im Plentation of the ISBA parameterization scheme for land surface processes in a GCM-an annum cycle experiment显示文摘 | Manzi A O Planto S | 1994 | Journal of Hydrology1994，155，34： | 1 |
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