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| 1 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 2 | Fedometrial polyps and the risk of atypical hyperplasia on biopsies of unremarkable en- dometrium: a study on 694 patients with benign endometrial polyps显示文摘 | Rahimi S Marani C Renzi C | 2009 | Int J Gynecol Pathol2009，28，4： | 1 |
| 3 | Geochemistry of metalliferous,hydrothermal deposits in the Aeolian arc(Tyrrhenian Sea)显示文摘 | Savelli C Marani M Gamberi F | 1999 | Journal of Volcanology and Geothermal Research1999，88，： | 1 |
| 4 | Endometrial polyps and the risk of atypical hyperplasia on biopsies of unremarkable endometrium: a study on 694 patients with benign endometrial polyps 显示文摘 | Rahimi S Marani C | 2009 | Int J Gyneeol Pathol2009，28，： | 1 |
| 5 | Endometrial polyps and the risk of atypical hyperplasia on biopsies of unremarkable endo- metrium: a study on 694 patients with benign endometrial pol- yps 显示文摘 | Rahimi S Marani C Renzi C | 2009 | Int J Gynecol Pathol2009，28，6： | 1 |
| 6 | OsmoFrozen Fruits:Mass Transfer and Quality Evaluation显示文摘 | Marani C M Agnelli M E Mascheroni R H | | 0，，79： | 1 |
| 7 | Shallow-water polymetallic sulfide deposits in the Aeolian island arc显示文摘 | Marani M P Gamberi F Savelli C | 1997 | Geology1997，25，： | 1 |
| 8 | Ependymoma with neuropil-like islands:a case report with diagnostic and histogenetic implications显示文摘 | Gessi M Marani C Geddes J | 2005 | Acta Neuropathol2005，109，： | 1 |
| 9 | MafB is a down- stream target of the IL-10/STAT3 signaling pathway, involved in the regulation of macrophage de-activation 显示文摘 | Gemelli C Zanocco Marani T Bicciato S | 2014 | Biochim Biophys Acta2014，1843，5： | 1 |
| 10 | Failures in snoring and OSAS surgery显示文摘 | Vicini C Marani M Frasconi PC | 1999 | Facial Plast Surg1999，15，4： | 1 |
| 11 | Osmo-frozen fruits: mass transfer and quality evaluation显示文摘 | Marani C M Agnelli M E Mascheroni R H | 2007 | Journal of Food Engineering2007，79，4： | 1 |
| 12 | DNA mismatch repair protein expression and microsatellite instability in primary mucosal melanomas of the head and neck 显示文摘 | Marani C Alvino E Caporali S | 2007 | Histopathology2007，50，6： | 1 |
| 13 | Endometrial pol-yps and the risk of atypical hyperplasia on biopsies ofunremarkable endometrium: a study on 694 patientswith benign endometrial polyps 显示文摘 | Rahimi S Marani C Renzi C | 2009 | Int J GynecolPathol2009，28，： | 1 |
| 14 | Endometrial polyps and the risk of atypical hyperplasia on biopsies of unremarkable endometrium: a study on 694 patients with benign endometrial polyps显示文摘 | Rahimi S Marani C | 2009 | Int J Gynecol Pathol2009，28，6： | 1 |
| 15 | Mechanisms of sodium azide-induced changes in intracellular calcium concentration in rat primary cortical neurons 显示文摘 | Marino S Marani L Nazzaro C Beani L Siniscalchi A | 2007 | Neurotoxicology2007，28，3： | 1 |
| 16 | Shallow-water polymetallic sufide deposits in the Aeolian island arc 显示文摘 | Marani M P Gamberi F Savelli C | 1997 | Geology1997，25，： | 1 |
| 17 | Modelling of heat and mass transfer during (osmo) dehydrofreezing of fruits 显示文摘 | Agnelli M E Marani C M Mascheroni R H | 2005 | Journal of Food Engineering2005，69，4： | 1 |
| 18 | Underwater target localization显示文摘 | MARANI G SONG C | | 0，，01： | 1 |
| 19 | The vitamin D3/Hox-A10 Pathway Supports MafB Function during the Monocyte Differen-tiation of Human CD34 + Hemopoietic Progenitors 显示文摘 | Gemelli C Orlandi C Zanocco Marani T | 2008 | J Immunol2008，181，8： | 1 |
| 20 | Behavior of Cd, Cr, Mn, Ni, Pb, and Zn in sewage sludge incineration by fluidized bed furnace 显示文摘 | D Marani C M Braguglia G Mininni | 2003 | Waste Management2003，23，： | 1 |
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