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| 1 | Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats显示文摘AIM: To investigate the effects of ketamine anesthesia on the motility alterations and tissue injury caused by ischemia/reperfusion in rats. METHODS: Thirty male Wistar rats weighing 200-250 g were used. Ischemia was induced by ob-structing blood flow in 25% of the total small intesti-nal length (ileum) with a vascular clamp for 45 min, after which either 60 min or 24 h of reperfusion was allowed. Rats were either anesthetized with pento-barbital sodium (50 mg/kg) or ketamine (100 mg/kg). Control groups received sham surgery. After 60 min of reperfusion, the intestine was examined for mor-phological alterations, and after 24 h intestinal basic electrical rhythm (BER) frequency was calculated, and intestinal transit determined in all groups. RESULTS: The intestinal mucosa in rats that were anesthetized with ketamine showed moderate altera-tions such as epithelial lifting, while ulceration and hemorrhage was observed in rats that received pento-barbital sodium after 60 min of reperfusion. Quantita-tive analysis of structural damage using the Chiu scaleshowed significantly less injury in rats that received ketamine than in rats that did not (2.35 ± 1.14 vs 4.58 ± 0.50, P < 0.0001). The distance traveled by a mark-er, expressed as percentage of total intestinal length, in rats that received pentobarbital sodium was 20% ± 2% in comparison with 25.9% ± 1.64% in rats that re-ceived ketamine (P = 0.017). BER was not statistically different between groups. CONCLUSION: Our results show that ketamine anesthesia is associated with diminished intestinal injury and abolishes the intestinal transit delay induced by ischemia/reperfusion. | Carlos Rodrigo Cámara Francisco Javier Guzmán Ernesto Alexis Barrera Andrés Jesús Cabello Armando Garcia Nancy Esthela Fernández Eloy Caballero Jesus Ancer | 2008 | World Journal of Gastroenterology2008，14，33： | 5 |
| 2 | Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease显示文摘Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 years.Parkinson’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postural instability,as a result of the progressive loss of nigrostriatal dopaminergic neurons.In addition to this neuronal cell loss,Parkinson’s disease is characterized by the accumulation of intracellular protein aggregates,Lewy bodies and Lewy neurites,composed primarily of the proteinα-synuclein.Although it was first described almost 200 years ago,there are no disease-modifying drugs to treat patients with Parkinson’s disease.In addition to conventional therapies,non-pharmacological treatment strategies are under investigation in patients and animal models of neurodegenerative disorders.Among such strategies,environmental enrichment,comprising physical exercise,cognitive stimulus,and social interactions,has been assessed in preclinical models of Parkinson’s disease.Environmental enrichment can cause structural and functional changes in the brain and promote neurogenesis and dendritic growth by modifying gene expression,enhancing the expression of neurotrophic factors and modulating neurotransmission.In this review article,we focus on the current knowledge about the molecular mechanisms underlying environmental enrichment neuroprotection in Parkinson’s disease,highlighting its influence on the dopaminergic,cholinergic,glutamatergic and GABAergic systems,as well as the involvement of neurotrophic factors.We describe experimental pre-clinical data showing how environmental enrichment can act as a modulator in a neurochemical and behavioral context in different animal models of Parkinson’s disease,highlighting the potential of environmental enrichment as an additional strategy in the management and prevention of this complex disease. | Tamara Andrea Alarcón Sarah Martins Presti-Silva Ana Paula Toniato Simões Fabiola Mara Ribeiro Rita Gomes Wanderley Pires | 2023 | Neural Regeneration Research2023，18，7： | 2 |
| 3 | Feed form and energy concentration of the diet affect growth performance and digestive tract traits of brown-egg laying pullets from hatching to 17 weeks of age显示文摘 | Saldana B Guzmán P Cámara L | 2015 | Poult Sci2015，94，8： | 1 |
| 4 | Microwave-assisted methylation of phenols with tetramethylammonium chloride in the presence of K2CO3 or Cs2CO3 显示文摘 | Maras N Polanc S Kocevar M | 2008 | Tetrahedron2008，64，11： | 1 |
| 5 | Deciphering the emerging role of SUMO conjugation in the hypoxia-signaling cascade显示文摘 | Nú?ez-O'Mara A Berra E | 2013 | Biol Chem2013，394，4： | 1 |
| 6 | High-temperature mechanical behavior/ microstructurecorrelation of Cu/Nb nanoscale multilayers 显示文摘 | MARA N A MISTRA A HOAGLAND R G | 2008 | Materials Science and Engineering : A2008，493，： | 1 |
| 7 | Impacts ofstress and disturbance factors on the phytoplankton communities inNortheastern Brazil reservoir显示文摘 | CHELLAPPA N T CHELLAPPA T C MARA F R A | 2009 | Limnologica2009，39，： | 1 |
| 8 | Photodegradation and Removal of Diclofenac by the Green Alga Nannochloropsis oculata显示文摘The emerging contaminants(ECs)are organic compounds including pharmaceuticals.These products are consumed in large quantities,favoring their continuous entrance to the environment and affecting the health of living beings.Diclofenac is a non-steroidal anti-inflammatory drug with analgesic properties of prolonged release.It is the commonest postoperative analgesic,and it is highly consumed without prescription.In recent years,the capability of microalgae to remove pharmaceuticals in water has been tested as a promising tool.In this work,the removal efficiency of diclofenac(16µg/mL)by the microalga Nannochloropsis oculata CCAP 186/7 was evaluated.The major nutrient concentrations in Bold’s Basal Medium were modified(nitrogen and carbon:50 and 100%of their original concentration)to know their effect in the removal of diclofenac.Drug degradation by light was also evaluated.The maximum removal capacity of diclofenac in the medium was 68.8%.The percentage of diclofenac adsorbed on the cell wall was between 6 and 12.7%.Around 23.6%of diclofenac was degraded by light after 18 days.N.oculata did not show growth inhibition due to the presence of diclofenac.The results obtained point to the promissory application of N.oculata as a bioremediation system for diclofenac removal. | Danaé Samara Sánchez-Sandoval Omar González-Ortega Mara Fernanda Navarro-Martínez Juan Marcos Castro-Tapia Ramón Fernando García de la Cruz Ruth Elena Soria-Guerra | 2021 | Phyton-International Journal of Experimental Botany2021，90，5： | 1 |
| 9 | Effectof surface chemistry, so- lution pH, and ionic strength on the removal of herbicides diuron and amitrole from water by an activated carbon fiber 显示文摘 | FONTECHA-CA' MARA M A LO' PEZ-RAMO' N M V Al- VAREZ-MERINO M A | 2007 | Langmttir2007，23，3： | 1 |
| 10 | Composition and run-time adaptation of mismatching behavioral interfaces显示文摘 | Cámara J Salaün G Canal C | 2008 | J UCS2008，14，13： | 1 |
| 11 | Management of domestic wastewater for reuse in irrigation显示文摘 | Vazquezmontiel O Horan N J Mara D D | 1996 | Water Sci Technol1996，33，1011： | 1 |
| 12 | Crop residue influences on soil carbon and nitrogen in a wheat-fallow system显示文摘 | Rasmussen P E All maras R R Roager Jr N C | 1980 | Soil Science Society of American Journal1980，44，7： | 1 |
| 13 | Integrin signalling: The tug-of-war in heart hypertrophy显示文摘 | Mara B Emilio H Antonella N | 2006 | Cardiovascular Research2006，70，： | 1 |
| 14 | Management of domestic wastewater for reuse in irrigation 显示文摘 | Vazquez-Montiel O Horan N J Mara D D | 1996 | Water Science and Technology1996，33，1011： | 1 |
| 15 | Heterogeneous and homogeneous Fenton processes using activated carbon for the removal of the herbicide amitrole from water显示文摘 | Fontecha-Cámara M A álvarez-Merino M A Carrasco-Marín F | 2011 | Applied Catalysis B: Environmental2011，101，3： | 1 |
| 16 | The combined role of topography and overstorey tree composition in promoting edaphic and floristic variation in a Mediterranean forest显示文摘 | S. Maltez-Mouro L. V. García T. Mara?ón H. Freitas | 2005 | Ecological Research2005，，6： | 1 |
| 17 | Denitfifica- tion of wastewater containing high nitrate and calcium concentrations 显示文摘 | Fern Ndez-Nava Y Mara N E Soons J | 2008 | Bioresource Technology2008，99，17： | 1 |
| 18 | Coke Wastewater Treatment by a Three-Step Activated Sludge System显示文摘 | E. Mara?ón I. Vázquez J. Rodríguez L. Castrillón Y. Fernández | 2008 | Water Air and Soil Pollution (-)2008，，1： | 1 |
| 19 | Relationship between antioxidant capacity and total phenolic content of red,rosé and white wines显示文摘 | Paix(a)o N Perestrelo R Marques JC C(a)mara JS | | 0，，01： | 1 |
| 20 | Sepsis: Going to the Heart of the Matter显示文摘 | Celes Mara R N Prado Cibele M Rossi Marcos A | 2012 | Pathobiology2012，，2： | 1 |
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