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您的检索式：作者名="Marc Dorenkamp"
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| 1 | Effects of endothelin ET_A receptor blocker LU 135252 on cardiac remod-eling and survival in a hypertensive rat model of chronic heart failure显示文摘瞄准:调查 endothelin 希腊语字母的第七字受体阻滞物是否在在长期的心力衰竭(CHF ) 的一个高血压的老鼠模型的心脏的改变和幸存上提供类似的利益。方法:男性击容易自发地, hypertensive (SHR-SP ) 老鼠受到左冠的动脉的永久结扎并且与 endothelin 希腊语字母的第七字受体阻滞物 LU 135252 被对待 6 个星期(30 mg.kg (在结扎或 untreatment 以后开始 24 h 的 -1).d(-1)) 。假冒操作老鼠用作正常控制。吝啬的动脉的血压(地图),心搏率( HR ),左室的结束心脏舒张的压力( LVEDP ),左室的收缩性( LV dp/dt (最大)),左室的内部直径( LVD )和圆周( LVC ),氏族的厚度,左室的空隙的骨胶原内容(国际计算中心)和心重量( HW )在处理的结束被测量。结果:与未经治疗的组相比, LU 135252 趋于增加 HW (1.43 +/-0.03 对 1.38 +/-0.04 g;P> 0.05 ) ,增加的 LVD (7.65+/-0.24 公里对 6.58+/-0.14 公里;P<0.05 ) ,显著地增加的 LVC (30.11+/-0.83 公里对 24.82+/-0.85 公里;P< 0.01 ) 并且减少的左室的国际计算中心(3.79%+/-0.09% 对 6.71%+/-0.11% ;P< 0.01 ) ,稍微降低的地图(132+/-6 毫米汞柱对 142+/-4 毫米汞柱;P>0.05 ) ,减少的 LVEDP (14 4 毫米汞柱对 27+/-4 毫米汞柱;P<0.05 ) 并且改进 LV dp/dtmax (4230+/-450 mmHg/s 对 1950+/-400 mmHg/s;P<0.05 ) ;幸存没显著地被延长(13% 对 11% ;P=NS ) 。结论:在 CHF 的这个高血压的老鼠模型,然而,有 LU 135252 的长期的 endothelin 希腊语字母的第七字受体封锁改进心脏的血液动力学它不影响长期的幸存并且变得更坏心脏的改变。因此, endothelin 希腊语字母的第七字受体对手是不大可能的与 CHF 在病人的管理有一个重要角色。 | Qin-gui XIA Alexander REINECKE Marc DORENKAMP Mat Jap DAEMEN Reichiger SIMON Thomas UNGER | 2006 | Acta Pharmacologica Sinica2006，27，11： | 3 |
| 2 | MDCT in the diagnostic algorithm in patients with symptomatic atrial fibrillation显示文摘Atrial fibrillation(AF) is the most common supraventricular arrhythmia and a major cause of morbidity.Arrhythmogenic foci originating within the pulmonary veins(PVs) are an important cause of both paroxysmal and persistent AF.A variety of endovascular and surgical techniques have been used to electrically isolate the PV from the left atrium.Pulmonary venography for localization of the PV ostium can be difficult to perform during the ablation procedure.While the anatomy of the PV is patientspecific,non-invasive imaging techniques may provide useful diagnostic information prior to the intended intervention.In this context,multidetector computed tomography(MDCT) visualization of the left atrial and PV anatomy prior to left atrial ablation and PV isolation is becoming increasingly important.MDCT imaging provides pre-procedural information on the left atrial anatomy,including atrial size and venous attachments,and it may identify potential post-procedural complications,such as pulmonary vein stenosis or cardiac perforations.Here,we review the relevant literature and present the current'state-of-the-art'of left atrial anatomy,PV ostia as well as the clinical aspects of refractory AF with MDCT imaging protocols and procedural aspects of PV ablation. | Christian Sohns Dirk Vollmann Lars Luethje Marc Dorenkamp Joachim Seegers Jan D Schmitto Markus Zabel Silvia Obenauer | 2011 | World Journal of Radiology2011，3，2： | 0 |
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