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| 1 | Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials显示文摘 | Guglielmo Ronco Joakim Dillner K Miriam Elfstr?m Sara Tunesi Peter J F Snijders Marc Arbyn Henry Kitchener Nereo Segnan Clare Gilham Paolo Giorgi-Rossi Johannes Berkhof Julian Peto Chris J L M Meijer | 2013 | The Lancet2013，，： | 3 |
| 2 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 3 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 4 | NT-3 Expression from Engineered Olfactory Ensheathing Glia Promotes Spinal Sparing and Regeneration显示文摘 | Marc J R Dane B L Seok V L | 2005 | Brain2005，，128： | 1 |
| 5 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 6 | Effect of the reaction temperature and hydrocarbon partial pressure on the activity of carbon-modified MoO3 for n-hexane isomerization 显示文摘 | Pascale D Cuong P H Marc J L | 1997 | Appl Catal A1997，149，1： | 1 |
| 7 | Comparison of vasopeptidase inhibitor,omapatrilat,and lisinopril on exercise tolerance and morbidity in patients with heart failure:IMPRESS randomised trial显示文摘 | Rouleau Jean L Pfeffer Marc A Stewart Duncan J | 2000 | Lancet2000，356，： | 1 |
| 8 | Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial显示文摘 | Jayant S Vaidya David J Joseph Jeffrey S Tobias Max Bulsara Frederik Wenz Christobel Saunders Michael Alvarado Henrik L Flyger Samuele Massarut Wolfgang Eiermann Mohammed Keshtgar John Dewar Uta Kraus-Tiefenbacher Marc Sütterlin Laura Esserman Helle MR Ho | 2010 | The Lancet2010，，9735： | 1 |
| 9 | Face recognition by elastic graph matching显示文摘 | Wiskott L Marc F J Kruger N | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelligence1997，19，7： | 1 |
| 10 | Kinematics, topography, sh -ortening,and extrusion in the India-Eurasia collision显示文摘 | Xavier L P Marc F Laurent J | 2006 | Geo logical Society2006，268，： | 1 |
| 11 | Modeling biomass production and yield oihorticultural crops: a review显示文摘 | Marcelis L F M Heuvelink E Goudriaan J | 1998 | Scientia- horticuhurae1998，74，： | 1 |
| 12 | CLOSYS: Closed system for water and nutrient management in horticulture显示文摘 | Marcelis L Dieleman J Boulard T | 2005 | Acta Horticulturae2005，98，86： | 1 |
| 13 | Titanium alloys in total joint replacement a materials science perspective 显示文摘 | Marc L Rack H J | 1998 | Biomaterials1998，，19： | 1 |
| 14 | Formalised review of environmental enrichment for pigs in relation to political decision making显示文摘 | MARC B M JOHAN J Z PETRA L | 2006 | Applied Animal Behavior Scinece2006，98，： | 1 |
| 15 | Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gone p53 in human lung cells: a model for a mechanism of carcinogenesis 显示文摘 | Marc J M Wang L J | 1997 | Mutation Research/Re- views in Mutation Research1997，386，3： | 1 |
| 16 | Detection of theβ2-toxin gene of clostridium perfringens in diarrhoeic piglets in the Netherlands and Switzerland显示文摘 | Henricus L B Mklaasen Marc J C | 1999 | FEMS Immunology and Medical Microbiology1999，24，： | 1 |
| 17 | Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production显示文摘 | Bert K Lopansri Nicholas M Anstey J Brice Weinberg Gregory J Stoddard Maurine R Hobbs Marc C Levesque Esther D Mwaikambo Donald L Granger | 2003 | The Lancet2003，，9358： | 1 |
| 18 | Methionine sulfoxide reductase A is important for lens cell viability and re- sistance to oxidative stress显示文摘 | MARC K HAWSE J R COWELL T L | 2004 | ProcNatl Acad Sci USA2004，101，26： | 1 |
| 19 | Formalised review of environmental enrichment for pigs in relation to political decision making显示文摘 | Marc B M Johan J Z Petra L | 2006 | Applied Animal Behavior Science2006，98，： | 1 |
| 20 | Modelling biomass production and yield of horticultural crop: A review显示文摘 | Marcelis L F M Heuvelink E Goudriaan J | 1998 | Scientia Horticulturae1998，74，1： | 1 |
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