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| 1 | Prognostic relevance of normocytic anemia in elderly patients affected by cardiovascular disease显示文摘BACKGROUND Anemia associated with cardiovascular diseases(CVD) is a common condition in older persons. Prevalence and prognostic role of anemia were extensively studied in patients with myocardial infarction(MI) or congestive heart failure(CHF) whereas limited data were available on patients with atrial fibrillation(AF). This study was conducted to assess the clinical prevalence and prognostic relevance of anemia in elderly patients affected by AF and other CVDs.METHODS A total of 866 elderly patients(430 men and 436 women, age: 65-98 years, mean age: 85 ± 10 years) were enrolled.Among these patients, 267 patients had acute non-ST-segment elevation MI(NSTEMI), 176 patients had acute CHF, 194 patients had acute AF and 229 patients were aged-matched healthy persons(CTR). All parameters were measured at the hospital admission and cardiovascular mortality was assessed during twenty-four months of follow-up.RESULTS The prevalence of anemia was higher in NSTEMI, CHF and AF patients compared to CTR subjects(50% vs. 15%, P <0.05), with normocytic anemia being the most prevalent type(90%). Adjusted mortality risk was higher in anemic patient versus non-anemic patient in all the groups of patients [NSTEMI: hazard ratio(HR) = 1.81, 95% CI: 1.06-2.13;CHF: HR = 2.49, 95% CI:1.31-4.75;AF: HR = 1.98, 95% CI: 1.01-3.88]. Decreased hemoglobin levels(P = 0.001) and high reticulocyte index(P = 0.023) were associated with higher mortality in CVD patients.CONCLUSIONS The significant associations between CVD and anemia and the prognostic relevance of anemia for elderly patients with CVD were confirmed in this study. The presence of anemia in AF patients is associated with a two-fold increased mortality risk compared with non-anemic AF patients. Low hemoglobin and high reticulocyte count independently predict mortality in elderly patients with CVD. | Liana Spazzafumo Fabiola Olivieri Jacopo Sabbatinelli Roberta Galeazzi Rina Recchioni Fiorella Marcheselli Paola Tamburrini Roberto Antonicelli | 2021 | Journal of Geriatric Cardiology2021，18，8： | 3 |
| 2 | Apoptosis in human aortic endothelial dells induced by hyper- glycemic condition involves mitochondrial depolariza- tion and is prevented by N acetyl-L-cysteine显示文摘 | Reechioni R Marcheselli F Moroni F | 2002 | Me- tabolism2002，51，11： | 1 |
| 3 | Renin-angiostensin system and stroke显示文摘 | Marcheselli S Mieieli G | 2008 | Neurol Sei2008，29，2： | 1 |
| 4 | Introduction of fituximab in front - line and salvage therapies has improved outcome of advanced - stage follicular lymphoma patients 显示文摘 | Sacchi S Pozzi S Marcheselli L | 2007 | Cancer2007，109，10： | 1 |
| 5 | Role of monitoring in management of acute ischemic stroke patients显示文摘 | Micieli G Marcheselli S et a1 | 2003 | Stroke2003，34，11： | 1 |
| 6 | SSJD14101300034250显示文摘 | Federica Domati Stefania Maffei Shaniko Kaleci Carmela Gregorio Monica Pedroni Luca Roncucci Piero Benatti Giulia Magnani Luigi Marcheselli Luca Reggiani Bonetti Francesco Mariani Antonio Maria Alberti Valerio Rossi Maurizio Ponz de Leon | 2014 | Internal and Emergency Medicine2014，，6： | 1 |
| 7 | Autonomic dysfunction in Parkinson' s disease 显示文摘 | Micieli G Tosi P Marcheselli S | 2003 | Neurol Sci2003，24，1： | 1 |
| 8 | Melatonin: A peroxyl radical scavenger more effective than vitamin E 显示文摘 | Marra M Moroni F Recchioni R Marcheselli F | 1994 | Life Sci1994，55，15： | 1 |
| 9 | Safety and efficacy of alteplase in the treatment of acute ischemic stroke显示文摘 | Micieli G Marcheselli S Tosi PA | 2009 | Vasc Health Risk Manag2009，5，1： | 1 |
| 10 | Role of monitoring in management of acute ischemic stroke patients显示文摘 | Cavallini A MicieliG MarcheselliS | 2003 | Stroke2003，34，11： | 1 |
| 11 | Determination of L-dopa,carbidopa,3-O-methyldopa and entacapone in human plasma by HPLC-ED显示文摘 | Bugamelli F Marcheselli C Barba E | 2011 | J Pharm Biomed 4nal2011，54，3： | 1 |
| 12 | Distinct platelet-activating factor binding sites in synaptic endings and in intracellular membranes of rat cerebral cortex显示文摘 | MARCHESELLI V L ROSSOWSKA M J DOMINGO MT | 1990 | J BiolChem1990，265，16： | 1 |
| 13 | A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease显示文摘 | CUI J G MARCHESELLI V L | 2005 | J Clin Invest2005，115，10： | 1 |
| 14 | Novel antifoul- ing agent-zinc pyrithione:Stress induction and geno- toxicity to the marine mussel Mytilus galloprovin- cialis显示文摘 | Marcheselli M Azzoni P Mauri M | 2011 | Aquat Toxicol2011，102，12： | 1 |
| 15 | A new role for the SHATTERPROOF genes during Arabidopsis gynoecium development显示文摘 | COLOMBO M BRAMBILLA V MARCHESELLI R CAPORALI E KATER M M COLOMBO L | 2010 | Developmental Biology2010，337，2： | 1 |
| 16 | Neuroprotectin D1 : a docosahexaenoic acid- derived docosatriene protects human retinal pigment epithelial cells from oxidative stress 显示文摘 | Mukherjee PK VL Marcheselli CN Serhan | 2004 | USA : Proc Natl Acad Sci2004，101，： | 1 |
| 17 | Attenuated LTP in hipocampal dentate gyrus neurons of mice deficient in the PAF receptor显示文摘 | Chen C Magee JC Marcheselli V | 2001 | J Neurophysiol2001，85，1： | 1 |
| 18 | Lymph node evalu- ation in stage ⅡA colorectal cancer and its impact on patient prognosis: A population-based study 显示文摘 | Iachetta F Reggiani BL Marcheselli L | 2013 | Acta Oncol2013，52，8： | 1 |
| 19 | Prognostic models for dif- fuse large B--ceU lymphoma in the ritttximah era: a never--ending story显示文摘 | Bari A Marcheselli L Sacchi S | 2010 | Ann Oncol2010，21，7： | 1 |
| 20 | Distinct platelet-activating factor binding sites in synaptic endings and in intracellular membranes of rat cerebral cortex显示文摘 | Marcheselli VL Rossowska Domingo MT | 1990 | J Biol Chem1990，265，： | 1 |
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