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| 1 | Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability显示文摘AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric adenocarcinomas.METHODS: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). Detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact test.RESULTS: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and MSI.CONCLUSION: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression. | Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini | 2010 | World Journal of Gastroenterology2010，16，3： | 6 |
| 2 | AngiotensinⅡor epinephrine hemodynamic and metabolic responses in the liver of L-NAME induced hypertension and spontaneous hypertensive rats显示文摘AIM To study hepatic vasoconstriction and glucose release induced by angiotensin(Ang)Ⅱ or Epi in rats with pharmacological hypertension and spontaneously hypertensive rat(SHR).METHODS Isolated liver perfusion was performed following portal vein and vena cava cannulation; AngⅡ or epinephrine(Epi) was injected in bolus and portal pressure monitored; glucose release was measured in perfusate aliquots. RESULTS The portal hypertensive response(PHR) and the glucose release induced by AngⅡ of L-NAME were similar to normal rats(WIS). On the other hand, the PHR inducedby Epi in L-NAME was higher whereas the glucose release was lower compared to WIS. Despite the similar glycogen content, glucose release induced by AngⅡ was lower in SHR compared to Wistar-Kyoto rats although both PHR and glucose release induced by Epi in were similar. CONCLUSION AngⅡ and Epi responses are altered in different ways in these hypertension models. Our results suggest that inhibition of NO production seems to be involved in the hepatic effects induced by Epi but not by AngⅡ; the diminished glucose release induced by AngⅡ in SHR is not related to glycogen content. | Debora Conte Kimura Marcia Regina Nagaoka Durval Rosa Borges Maria Kouyoumdjian | 2017 | World Journal of Hepatology2017，9，17： | 4 |
| 3 | Pseudomelanosis duodeni associated with chronic renal failure显示文摘Pseudomelanosis duodeni (PD) is a rare dark speckled appearance of the duodenum associated with gastrointestinal bleeding,hypertension,chronic heart failure,chronic renal failure and consumption of different drugs.We report four cases of PD associated with chronic renal failure admitted to the gastroenterology outpatient unit due to epigastric pain,nausea,melena and progressive reduction of hemoglobin index.Gastroduodenal endoscopy revealed erosions in the esophagus and stomach,with no active bleeding at the moment.In addition,the duodenal mucosa presented marked signs of melanosis;later confirmed by histopathological study.Even though PD is usually regarded as a benign condition,its pathogenesis and clinical significance is yet to be defined. | Marcia Henriques de Magalhes Costa Maria da Gloria Fernandes Pegado Cleber Vargas Maria Elizabeth C Castro Kalil Madi Tiago Nunes Cyrla Zaltman | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 4 | Grain-size end-members and environmentally sensitive grain-size components: A comparative study in the mud shelf depocenters off southern Brazil显示文摘The current study aims to do a comparative analysis of the results obtained with two End-Member(EM)grain-size modeling techniques(AnalySize and BasEMMA)and the Environmental Sensitive Grain-Size(ESGS)modeling for sediment samples collected in the mudbelts of the southern Brazilian shelf.The methods were compared using grain-size data from the south Brazilian shelf,and the results are discussed here.It is the first time that the concept of ESGS,in its present form,is utilized outside China.The results show that despite its relative ease of use,the ESGS is not fully comparable to the EM analyses,and only two grain-size ESGS classes were recognized as analogous to EMs.The comparison of the AnalySize and BasEMMA procedures also revealed significant differences between the techniques.A comparative analysis between the two EM techniques revealed advantages in the BasEMMA,especially in the better correlation of the end-members with the original grain size distribution.The analysis of the geographical distribution of the EM abundances allowed point sources of sandy populations to be recognized as well as the contribution of the Rio de la Plata as a source of silty sediments to be inferred. | Michel Michaelovitch de Mahiques Samara Cazzoli y Goya Maria Carolina da Silva Nogueira de Matos Rodrigo Augusto Udenal de Oliveira Bianca Sung Mi Kim Paulo Alves de Lima Ferreira Rubens Cesar Lopes Figueira Marcia Caruso Bícego | 2021 | International Journal of Sediment Research2021，36，2： | 2 |
| 5 | Assessment of disease activity in inflammatory bowel diseases:Non-invasive biomarkers and endoscopic scores显示文摘Inflammatory bowel diseases(IBD)comprise two major forms:Crohn’s disease and ulcerative colitis.The diagnosis of IBD is based on clinical symptoms combined with results found in endoscopic and radiological examinations.In addition,the discovery of biomarkers has significantly improved the diagnosis and management of IBD.Several potential genetic,serological,fecal,microbial,histological and immunological biomarkers have been proposed for IBD,and they have been evaluated for clinical routine and clinical trials.Ileocolonoscopy,especially with biopsy collection,has been considered the standard method to diagnose IBD and to assess clinical activity of the disease,but it is limited to the colon and terminal ileum and is considered invasive.For this reason,non-invasive biomarkers are necessary for this type of chronic inflammatory disease,which affects mostly young individuals,as they are expected to have a long follow-up. | Bruno Lima Rodrigues Marcia Carolina Mazzaro Cristiane Kibune Nagasako Maria de Lourdes SetsukoAyrizono Joao Jose Fagundes Raquel Franco Leal | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，12： | 2 |
| 6 | Therapeutic and biological activities of Calotropis procera(Ait.) R.Br.显示文摘Medicinal plants have been used to treat various ailments of the poor population around the world;hence the interest among researchers to know the active ingredients of certain plants has being increased.The Calotropis procera(C.procera) is a plant original from Africa,commonly found in northeastern Brazil.It is well known for their pharmacological properties,since it produces large amounts of latex.The important role that medicinal plants play in folk medicine has led us to develop this article in order to review the major pharmacological activities of C. procera. | Marcia Calheiros Chaves Silva Antonio Batista da Silva Fabiano Moura Teixeira Paulo Cesar Pereira de Sousa Regina Maria Macedo Rondon Jose Eduardo Ribeiro Honorio Junior Luiz Rafael Leite Sampaio Samanda Lima Oliveira Angela Nadyla Martins Holonda Silvania Maria Mendes de Vasconcelos | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 2 |
| 7 | Hybrid films based on hydrox- ylated castor oil and titanium ( Ⅳ ) isopropoxide 显示文摘 | Marcia M Maria A | 2009 | Sol-gel Science and Technology2009，52，： | 1 |
| 8 | Antinocicepfive properties of momsin, a prenylflavonoid isolated from Morus nigra Root Bark显示文摘 | De Souza Marcia Maria Bittar Magali | 2000 | J Biosei2000，55，： | 1 |
| 9 | Biodiesel compatibility with carbon steel and HDPE parts显示文摘 | Marcia Marie Maru Marcia Maria Lucchese Cristiano Legnani Welber Gianini Quirino Andrea Balbo Isabele Bulh?es Aranha Lílian Terezinha Costa Cecília Vilani Lídia ágata de Sena Jailton Carreteiro Damasceno Talita dos Santos Cruz Leandro Reis Lidízio Rui Fer | 2009 | Fuel Processing Technology2009，，9： | 1 |
| 10 | Toxicities, complications, and clinical encounters during intraperitoneal chemotherapy in 17 women with ovarian cancer显示文摘 | Virginia Sun Shirley Otis-Green Robert Morgan Mark Wakabayashi Amy Hakim Maria Elenita Callado Eunice Yang Betty Ferrell Marcia Grant | 2012 | European Journal of Oncology Nursing2012，，： | 1 |
| 11 | Development of methods for the determination of cadmium and thallium in oil shale by products with graphite furnace atomic absorption spectrometry using direct analysis显示文摘 | Helen R Oliveira Marcia F Mesko Maria Goreti R Vale | 2014 | Microchemical Journal2014，116，： | 1 |
| 12 | Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds显示文摘 | Thais Gaban Passalacqua Luiz Antonio Dutra Letícia de Almeida Angela Maria Arenas Velásquez Fabio Aurelio Esteves Torres Paulo Renato Yamasaki Mariana Bastos dos Santos Luis Octavio Regasini Paul A.M. Michels Vanderlan da Silva Bolzani Marcia A.S. Graminh | 2015 | Bioorganic & Medicinal Chemistry Letters2015，，： | 1 |
| 13 | Mycotoxins in fruits and their processed products: Analysis, occurrence and health implications 显示文摘 | Maria L Fernandez C Marcia L | 2010 | Journal of Advanced Research2010，1，2： | 1 |
| 14 | Production and properties of a surfactant obtained from Bacillus subtilis grown on cassava wastewater显示文摘 | Marcia Nitschke Glaucia Maria Pastore | 2006 | Bioresource technology2006，97，： | 1 |
| 15 | Biodiesel compatibility with carbon steel and HDPE parts显示文摘 | Marcia Marie Maru Marcia Maria Lucchese Cristiano Legnani | 2009 | Fuel Processing Technology2009，90，9： | 1 |
| 16 | The use of microemulsion for determination of sodium and potassium in biodiesel by flame atomic absorption spectrometry 显示文摘 | Alexandre de Jesus MArcia M Silva Maria Gorefi R Vale | 2008 | Talanta2008，74，5： | 1 |
| 17 | Hybrid films synthe- sised from epoxidised castor oil, - glycidoxypmpyltrim- ethoxysilane and tetraethoxysilane 显示文摘 | Maria A L Marcia M Barbieri C | 2009 | Progress in Or- ganic Coatings2009，65，： | 1 |
| 18 | Values and Valuing Across Cultures and Time Zones显示文摘Highlights:Values and valuing are seen as enhancing pedagogical actions.•Throughout the papers,the review of the literature is complemented and each research includes specific theoretical constructs.•Regarding research methods,quantitative comparative research projects,which explore students'values related to mathematics,have been influencing other research about values.•A broad and shared theme by the group is the observation of the educational phenomena from a perspective that acknowledges culture and the humanness of the mathematical knowledge.In their research,the collective of authors truly incorporates humaneness in the production and in the teaching and learning of mathematics. | Marcia Maria Fusaro Pinto | 2021 | ECNU Review of Education2021，4，2： | 1 |
| 19 | Nutritional,rheological and sensory properties of butter processed with different mixtures of cow and sheep milk cream显示文摘This study assessed the quality parameters and consumer perception and behavior of butter processed with different ratios of cow and sheep milk cream.Cow milk cream butter(CMCB)showed lower moisture content and higher fat content,smaller fat globules,and higher concentrations of long-chain saturated fatty acids and monounsaturated fatty acids,resulting in improved potential health indices.In addition,CMCB showed yellow color,little salt,and butter taste as the main sensory characteristics,resulting in grateful and good digestibility perceptions.Sheep milk cream addition improved the rheological properties of the products(lower viscosity,consistency index,and rigidity(J0),and higher fluidity and viscoelastic behavior(J1)),mainly due to the increased concentrations of short-chain and medium-chain saturated fatty acids and polyunsaturated fatty acids.However,sheep milk cream butter(SMCB)was characterized by a greasy and striking aroma,with a lower perception of good digestibility and good appearance,and a higher bitter taste.The association of cow and sheep milk cream could be an exciting option to obtain products with improved fatty acid profiles,health indices,and yet maintain desired rheological and sensory properties.The formulation with 60%sheep milk cream and 40%cow milk cream would be the suggested combination. | Renata S Dias Celso F.Balthazar Rodrigo N.Cavalcanti Louise A.Sobral Jessica F.Rodrigues Roberto P.CNeto Maria Inˆes B.Tavares Ana Paula B.Ribeiro Renato Grimaldi Celso Sant’Anna Erick A.Esmerino Tatiana C.Pimentel Marcia Cristina Silva Adriano G.Cruz | 2022 | Food Bioscience2022，46，2： | 1 |
| 20 | Characterization of magnetic microspherers based on network styrene and divinylbenzene copolymers 显示文摘 | L C de Santa Maria Marcia C A M Leite Marcos A S Costa | 2004 | Materials Letters2004，58，： | 1 |
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