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| 1 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 2 | Noninvasive ventilation in trauma显示文摘Trauma patients are a diverse population with heterogeneous needs for ventilatory support. This requirement depends mainly on the severity of their ventilatory dysfunction, degree of deterioration in gaseous exchange, any associated injuries, and the individual feasibility of potentially using a noninvasive ventilation approach. Noninvasive ventilation may reduce the need to intubate patients with traumarelated hypoxemia. It is well-known that these patientsare at increased risk to develop hypoxemic respiratory failure which may or may not be associated with hypercapnia. Hypoxemia in these patients is due to ventilation perfusion mismatching and right to left shunt because of lung contusion, atelectasis, an inability to clear secretions as well as pneumothorax and/or hemothorax, all of which are common in trauma patients. Noninvasive ventilation has been tried in these patients in order to avoid the complications related to endotracheal intubation, mainly ventilator-associated pneumonia. The potential usefulness of noninvasive ventilation in the ventilatory management of trauma patients, though reported in various studies, has not been sufficiently investigated on a large scale. According to the British Thoracic Society guidelines, the indications and efficacy of noninvasive ventilation treatment in respiratory distress induced by trauma have thus far been inconsistent and merely received a low grade recommendation. In this review paper, we analyse and compare the results of various studies in which noninvasive ventilation was applied and discuss the role and efficacy of this ventilator modality in trauma. | Marcin K Karcz Peter J Papadakos | 2015 | World Journal of Critical Care Medicine2015，4，1： | 3 |
| 3 | Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70显示文摘AIM: To determine whether ischemic preconditioning (IP)affects the development of edematous cerulein-induced pancreatitis and to assess the role of cyclooxygenase-1 (COX-1), COX-2, and heat shock protein 70 (HSP 70) in this process.METHODS: In male Wistar rats, IP was performed by damping of celiac artery (twice for 5 min at 5-min intervals).Thirty minutes after IP or sham operation, acute pancreatitis was induced by cerulein. Activity of COX-1 or COX-2 was inhibited by resveratrol or rofecoxib, respectively (10 mg/kg).RESULTS: IP significantly reduced pancreatic damage in cerulein-induced pancreatitis as demonstrated by the improvement of pancreas histology, reduction in serum lipase and poly-C ribonuclease activity, and serum concentration of pro-inflammatory interleukin (IL)-1β.Also, IP attenuated the pancreatitis-evoked fall in pancreatic blood flow and pancreatic DNA synthesis.Serum level of anti-inflammatory IL-10 was not affected by IP. Cerulein-induced pancreatitis and IP increased the content of HSP 70 in the pancreas. Maximal increase in HSP 70 was observed when IP was combined with cerulein-induced pancreatitis. Inhibition of COXs, especially COX-2, reduced the protective effect of IP in edematous pancreatitis.CONCLUSION: Our results indicate that IP reduces pancreatic damage in cerulein-induced pancreatitis and this effect, at least in part, depends on the activity of COXs and pancreatic production of HSP 70. | Zygmunt Warzecha Artur Dembinski Piotr Ceranowicz Stanislaw J Konturek Marcin Dembinski Wieslaw W Pawlik Romana Tomaszewska Jerzy Stachura Beata Kusnierz-Cabala Jerzy W Naskalski Peter C Konturek | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 4 | ScaI polymorphism of the atrial natriuretic peptide gene and blood pressure in subjects without clinical manifestations of atherosclerotic disease显示文摘 | Jerzy B Marcin G Siebert J | 1999 | Arterial Hypertension1999，3，4： | 1 |
| 5 | Circulating vascular endothelial growth factor and its soluble receptors in patients with liver cirrhosis: Possible association with hepatic function impairment显示文摘 | JERZY J MARCIN J ROBERT F | 2008 | Cytokine2008，44，1： | 1 |
| 6 | Isolation and characterization of two new lipopeptide iosurfactants produced by pseudomonas fluorescens BD5isolated from water from the Arctic Archipelago of Svalbard显示文摘 | Tomasz J Marcin Tomas R | 2010 | Bioresource Technology2010，101，15： | 1 |
| 7 | Temperature and N:P ratio as factors causing blooms of blue-green algae in the Gulfof Gdańsk显示文摘 | Marcin P Tomasz J | 1999 | Oceanologia1999，41，1： | 1 |
| 8 | Energy policy and the role of bioenergy in Poland显示文摘 | Lars J Nilsson Marcin Pisarek | 2006 | Energy Policy2006，34，： | 1 |
| 9 | Expression of Ecadherin,β-catenin and Ki-67 antigen and their reciprocal relationships in mammary adenocarcinomas in bitches显示文摘 | MARCIN N JANUSZ A MADE J | 2007 | ET Cytobiologica2007，3，45： | 1 |
| 10 | Serum B-type natriuretic peptide levels on admission predict not only short-term death but also angiographic success of procedure in patients with acute ST-elevation myocardial infarction treated with primary angioplasty显示文摘 | Marcin Grabowsbi Krzysztof J Filipiakm MD | 2004 | Am Heart J2004，148，： | 1 |
| 11 | Improved soft magnetic behaviour in field-annealed nanocrystalline Hitperm alloys 显示文摘 | Skorvanek I Marcin J Krenicly T | 2006 | J Magn Magn Mater2006，304，： | 1 |
| 12 | Total synthesis of (±)-batrachotoxinin A 显示文摘 | Kurosu M Marcin L R Grinsteiner T J | 1998 | J Am Chem Soc1998，120，26： | 1 |
| 13 | Hierarchies of belief and interim ra-tionalizability 显示文摘 | Ely J Marcin Peski | 2005 | Theoretical Eonomics2005，，： | 1 |
| 14 | Mitsunobu reaction of n-alkyl and n-aeyl sulfonamides-an efficient route to protected amines 显示文摘 | Henry J R Marcin L R MeIntosh M C | 1989 | Tetrahedron Lett1989，30，： | 1 |
| 15 | Preparation and Characterization of Ag-lntercalated Copper Hexacyanoferrate Films on Electrodes 显示文摘 | Marcin A M Pawel J K | 1996 | Electroanalysis1996，8，2： | 1 |
| 16 | Interobserver agreement inultrasonography of the finger and toe joints in rheumatoidarthritis显示文摘 | Marcin S Michel CP Soren J | 2003 | Arthritis Rheum2003，48，： | 1 |
| 17 | Polycystic ovary syndrome显示文摘 | Robet J Norman Ruijin Wu Marcin T Stankiewicz | 2004 | MJA2004，180，3： | 1 |
| 18 | Serum B-type natriuretic pep-tide levels on admission predict not only short-term death but also angio-graphic success of procedure in patients with acute ST-elevation myocardial infarction treated with primary angioplasty显示文摘 | Marcin Grabowsbi Krzysztof J | 2004 | Am Heart J2004，148，： | 1 |
| 19 | LC-MS/MS analysis of surface layer protein as a useful method for the identification of Lactobacilli from the Lactobacillus acidophilus group 显示文摘 | Podlesny Marcin Piotr J | 2011 | Microbiol Biotechnol2011，21，： | 1 |
| 20 | Thermal barrier coating experience in gas turbine engines at Pratt & Whitney 显示文摘 | Bose S De Masi Marcin J | 1997 | Journal of Thermal Pray Technology1997，6，1： | 1 |
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