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| 1 | The bad and the good of mesenchymal stem cells in cancer: Boosters of tumor growth and vehicles for targeted delivery of anticancer agents显示文摘In cancer biology,mesenchymal stem cells(MSCs)display aspects that can appear contradictory.On one hand,these cells possess several features which give them the ability to specifically target and then sustain cancer cells in their ability to survive the multifaceted host response against cancer.On the other hand,due to this excellent aptitude to home-in on tumor tissues,regardless their location in the host’s body,MSCs are considered to be extremely selective vehicles to reach cancer cells specifically.Recently,MSC sustainment of cancer cell growth is a hot research topic.Indeed,these cells are known to sustain tumor angiogenesis and metastasis formation,to create a microenvironment favorable for cancer cell growth and to down-modulate the immune system capabilities in the host organism.On the other hand,since scientists became able to take advantage of their extremely selective capability to target cancer cells,MSCs are now also thought of in a different light.Indeed,MSCs are now considered a promising vehicle for local expression or delivery of even particularly toxic anticancer agents,ranging from Herpes Simplex Virus to locally-acting antineoplastic drugs.On this basis,investigation is now focused on how to impair the pro-neoplastic features of MSCs on one hand whilst taking advantage of their specific tropism toward cancer cells,on the other.As with the two faces of Janus,this review will concisely explore the research activity in these two apparently conflicting fields. | Umberto Galderisi Antonio Giordano Marco G Paggi | 2010 | World Journal of Stem Cells2010，2，1： | 3 |
| 2 | Accuracy of a predictive model for severe hepatic fibrosis or cirrhosis in chronic hepatitis C显示文摘AIM: To assess the accuracy of a model in diagnosing severe fibrosis/cirrhosis in chronic hepatitis C virus (HCV)infection.METHODS: The model, based on the sequential combination of the Bonacini score (BS: ALT/AST ratio,platelet count and INR) and ultrasonography liver surface characteristics, was applied to 176 patients with chronic HCV infection. Assuming a pre-test probability of 35%,the model defined four levels of post-test probability of severe fibrosis/cirrhosis: <10% (low), 10-74% (not diagnostic), 75-90% (high) and >90% (almost absolute).The predicted probabilities were compared with the observed patients' distribution according to the histology (METAVIR).RESULTS: Severe fibrosis/cirrhosis was found in 67 patients (38%). The model discriminated patients in three comparable groups: 34% with a very high (>90%)or low (<10%) probability of severe fibrosis, 33% with a probability ranging from 75% to 90%, and 33% with an uncertain diagnosis (I.e., a probability ranging from 10%to 74%). The observed frequency of severe fibrosis/cirrhosis was within the predefined ranges.CONCLUSION: The model can correctly identify67% of patients with a high (>75%) or low (<10%) probability of cirrhosis, leaving only 33% of the patients still requiring liver biopsy. | Agostino Colli Alice Colucci Silvia Paggi Mirella Fraquelli Sara Massironi Marco Andreoletti Vittorio Michela Dario Conte | 2005 | World Journal of Gastroenterology2005，11，46： | 2 |
| 3 | A unified fractal approach for the interpretation of the anomalous scaling laws in fatigue and comparison with existing models 显示文摘 | Alberto Carpinteri Marco Paggi | 2010 | International Journal o f Fracture2010，161，1： | 1 |
| 4 | The coefficient of proportionality κ between real contact area and load, with new asperity models显示文摘 | Marco Paggi Michele Ciavarella | 2009 | Wear2009，，7： | 1 |
| 5 | Special issue on fracture and contact mechanics for interface problems显示文摘 | Marco Paggi Peter Wriggers | 2012 | Engineering Fracture Mechanics2012，，： | 1 |
| 6 | Self-similarity and Crack Growth Instability in the Correlation between the Pads' Constants 显示文摘 | Alberto Carpinteri Marco Paggi | 2007 | Engineering Fracture Mechanics (S0013-7944)2007，74，7： | 1 |
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