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| 1 | Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review显示文摘BACKGROUND Despite the advent of biological drugs, conventional therapy continues to be used in moderate to severe inflammatory bowel disease(MS-IBD). This study hypothesized that as a standard of treatment and the primary alternative to biologics, conventional therapy should present robust effectiveness results in IBD outcomes.AIM To investigate the effectiveness of conventional therapy for MS-IBD.METHODS A systematic review with no time limit was conducted in July 2017 through the Cochrane Collaboration, MEDLINE, and LILACS databases. The inclusion criteria encompassed meta-analyses, systematic reviews, randomized clinical trials, observational and case-control studies concerning conventional therapy in adult patients with MS-IBD, including Crohn's disease(CD) and ulcerative colitis(UC). Corticosteroids(prednisone, hydrocortisone, budesonide, prednisolone,dexamethasone), 5-aminosalicylic acid(5-ASA) derivatives(mesalazine and sulfasalazine) and immunosuppressants [azathioprine(AZA), methotrexate(MTX), mycophenolate, cyclosporine, tacrolimus, 6-mercaptopurine(6-MP)] were considered conventional therapy. The exclusion criteria were sample size below50; narrative reviews; specific subpopulations(e.g., pregnant women,comorbidities); studies on postoperative IBD; and languages other than English,Spanish, French or Portuguese. The primary outcome measures were clinical remission(induction or maintenance), clinical response and mucosal healing. As secondary outcomes, fecal calprotectin, hospitalization, death, and surgeries were analyzed. The quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation criteria.RESULTS The search strategy identified 1995 citations, of which 27 were considered eligible(7 meta-analyses, 20 individual studies). For induction of clinical remission, four meta-analyses were selected(AZA and 6-MP showed no advantage over placebo,MTX or 5-ASA in CD; MTX showed no statistically significant difference versus placebo, 6-MP, or 5-ASA in UC; tacrolimus was superior to placebo for UC in two meta-analyses). Only one meta-analysis evaluated clinical remission maintenance, showing no statistically significant difference between MTX and placebo, 5-ASA, or 6-MP in UC. AZA and 6-MP had no advantage over placebo in induction of clinical response in CD. Three meta-analyses showed the superiority of tacrolimus vs placebo for induction of clinical response in UC. The clinical response rates for cyclosporine were 41.7% in randomized controlled trials(RCTs) and 55.4% in non-RCTs for UC. For induction of mucosal healing,one meta-analysis showed a favorable rate with tacrolimus versus placebo for UC. For secondary outcomes, no meta-analyses specifically evaluated fecal calprotectin, hospitalization or death. Two meta-analyses were retrieved evaluating colectomy rates for tacrolimus and cyclosporine in UC. Most of the twenty individual studies retrieved contained a low or very low quality of evidence.CONCLUSION High-quality evidence assessing conventional therapy in MS-IBD treatment is scarce, especially for remission maintenance, mucosal healing and fecal calprotectin. | Adérson Omar Mourao Cintra Damiao Matheus Freitas Cardoso de Azevedo Alexandre de Sousa Carlos Marcela Yumi Wada Taciana Valéria Marcolino Silva Flávio de Castro Feitosa | 2019 | World Journal of Gastroenterology2019，25，9： | 13 |
| 2 | Molecular markers in acute and chronic phases of human toxoplasmosis: determination of immunoglobulin G avidity by Western blotting 显示文摘 | Marcolino PT Silva DA Leser PG | 2000 | Clin Diagn Lab Immunol2000，7，3： | 1 |
| 3 | Molecular markers in acute and chronic phases of human toxoplasmosis: determination of immu- noglobulin G avidity by Western blotting 显示文摘 | Marcolino PT Silva DA Leser PG | 2000 | Clin Diagn Lab Immu- nol2000，7，3： | 1 |
| 4 | Molecular markers in acute and chronic phases of human toxoplasmosis:determination of immunoglobulin G avidity by Western blotting显示文摘 | Marcolino PT Silva DAO Leser PG | 2000 | Clin Diagn Lab Immunol2000，7，： | 1 |
| 5 | Telemedicine application inthe care of diabetes patients : systematic review and meta-analysis 显示文摘 | Marcolino MS Maia JX Alkmim MB | 2013 | PLoS One2013，8，79： | 1 |
| 6 | Investigation of the chemical composition of nonmetallic inclu-sions utilizing ternary phase diagrams显示文摘 | Marcolino Fernandes Jose' Carlos Pires Noe' Cheung | 2003 | Materials Character- ization2003，49，： | 1 |
| 7 | Investiga- tion of nonmetallic inclusions in continuously cast carbon steel by dissolution of the ferritic matrix显示文摘 | Marcolino Femandes Noe' Cbeung Amauri Garcia | 2002 | Materials Characteriza- tion2002，48，： | 1 |
| 8 | Evaluation of the association between osteoporosis and postural balance in postmenopausal women显示文摘 | Guilherme Carlos Brech Pérola Grinberg Plapler Eduardo de Souza Meirelles Flora Maria D’Andrea Marcolino Júlia Maria D’Andrea Greve | 2013 | Gait & Posture2013，，2： | 1 |
| 9 | Teleconsultations to provide support for primary care practitioners and improve quality of care-the experience of a large scale telehealth service in brazil 显示文摘 | Marcolino MS Pereira Afonso dos Santos J Santos Neves D | 2015 | Stud Health Technol Inform2015，216，： | 1 |
| 10 | Interaction of curcumin and bixin with 13 - cyclodextrin: complexation methods,stability, and applications in food 显示文摘 | Marcolino VA Zanin GM Durrant LR | 2011 | Journal of Agricultural and Food Chemistry2011，59，7： | 1 |
| 11 | Molecular markers in acute and chronic phases of human toxoplasmosis: determination of immunoglobulin G avidity by western blotting 显示文摘 | Marcolino PT Silva DAO Leser PG | 2000 | Clin Diagn Lab Immunol2000，7，3： | 1 |
| 12 | Molecular markers in acute and chronic phases of human toxoplasmosis:determination of immunoglobulin G avidity by Western blotting显示文摘 | Marcolino PT Silva DA Leser PG | 2000 | Clin Diagn Lab Immunol2000，7，3： | 1 |
| 13 | Comparative effects of wavelengths of low-power laser in regeneration of sciatic nerve in rats following crushing lesion显示文摘 | Barbosa R I Marcolino A M de Jesus Guirro R R | 2010 | Lasersin medical science2010，25，3： | 1 |
| 14 | Molecular markers in acute and chronic phases of human toxoplasmosis: determination of immunoglobulin G avidity by western blotting显示文摘 | Marcolino PT Silva DA Leser PG | 2000 | Clin Diagn Lab Immunol2000，7，3： | 1 |
| 15 | Voltammetric determination of isoprenaline in pharmaceutical preparations using a copper(Ⅱ) hexacyanoferrate(Ⅲ) modified carbon paste electrode显示文摘 | BONIFACIO V G MARCOLINO L H TEIXEIRA M F S | 2004 | Microchem J2004，78，1： | 1 |
| 16 | Interaction of curcumin and bixin with β-cyclodextrin:complexation methods, stability,and applications in food显示文摘 | Marcolino VA Zanin GM Durrant LR | 2011 | Journal of Agricultural and Food Chemistry2011，59，7： | 1 |
| 17 | Telemedicine appli- cation in the care of diabetes patients: systematic review and meta-analysis显示文摘 | Marcolino MS Maia JX Alkmim MB | 2013 | PLoS One2013，8，79： | 1 |
| 18 | Investigation of Nonmetallic Inclusions in Continuously Cast Carbon Steel by Dissolution of the Ferritic Matrix 显示文摘 | Fernandes Marcolino Cheung Noe Garcia Amauri | 2002 | Materials Characterization2002，48，4： | 1 |
| 19 | Prebiotics in non-dairy products:Technological and physiological functionality,challenges,and perspectives显示文摘Vegan consumers look for fresh,tasty,and nutritious products that use eco/animal-friendly ingredients.Prebiotics are substrates selectively utilized by host microorganisms conferring a health benefit.This study aimed to overview the potentially vegan products added with prebiotics,their health benefits,and the main technological and sensory challenges.The main potentially vegan products added with prebiotics studied were based on water-soluble plant-based extracts(fermented beverages,frozen desserts,cheese analog),fruits(fruit juices,fruit jelly,and ready to eat fruits),and cereals(snack bars,granola bars,bread,and cookies).The main prebiotic compounds used were inulin,fructooligosaccharides,oligofructose,polydextrose,and xylooligosaccharides.The effects of prebiotic on food products’,host health,and technological and sensory properties depended on the prebiotic type and dosage,food matrix,and subject type.The positive health effects were related to skin health,gut microbiota improvement,hypocholesterolemic impact,reduction of the risk of metabolic diseases,and improvements in postprandial blood glucose and insulin response.Prebiotics could improve vegan products’technological and sensory properties,such as fermentation time,texture and rheological properties,storage length,sensory acceptance,and probiotic survival.Furthermore,they could increase the concentration and/or bioaccessibility of phenolic compounds and vitamins.However,it is of paramount importance the determination of prebiotic stability.The trends direct to new prebiotic compounds based on microalgae,fruit and cereal by-products,and seeds.This review provides industries and researchers with important information about prebiotics and vegan products. | Tatiana Colombo Pimentel Bianca Beatriz Torres de Assis Caique dos Santos Rocha Vanessa Aparecida Marcolino Michele Rosset Marciane Magnani | 2022 | Food Bioscience2022，46，2： | 1 |
| 20 | Prevalence and risk factors of Chlamydia trachomatis cervicitis in pregnant women at the genital tract infection in obstetrics unit care at Botucatu Medical School, S?o Paulo State University-UNESP, Brazil 显示文摘 | Ramos BR Polettini J Marcolino LD | 2011 | J Low Genit Tract Dis2011，15，1： | 1 |
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