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您的检索式：作者名="Marcotegui M"
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| 1 | Stepped-impedance lowpass filters with spurious pass-band suppression显示文摘 | J Garcia-Garcia J Bonache F Falcone J D Baena F Martin I Gil T Lopetegi M A G Laso A Marcotegui R Marques M Sorolla | 2004 | Electronic Letters2004，40，14： | 1 |
| 2 | Silencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloidleukemia 显示文摘 | Vazquez I Maicas M Marcotegui N | 2010 | Pro Natl Acad Sci U S A2010，107，44： | 1 |
| 3 | Pro- teins specified by African swine fever virus显示文摘 | Tabares E Marcotegui M A Fernandez M | 1980 | Arch Virol1980，66，： | 1 |
| 4 | Usefulness of echocardiography and Doppler echocardiography in endomyocardial fibrosis 显示文摘 | Berensztein CS Pineiro D Marcotegui M | 2000 | J Am Soc Echocardiogr2000，13，5： | 1 |
| 5 | Discriminatory capacity of serum interleukin-6 between complicated and uncomplicated acute appendicitis in children:a prospective validation study显示文摘Background Serum interleukin-6(IL-6)has a moderate diagnostic performance in pediatric acute appendicitis(PAA).The evidence regarding its capacity to discern between complicated and uncomplicated PAA is scarce.Methods We designed a prospective observational study to validate serum IL-6 as a marker for diagnostic classification between complicated and uncomplicated PAA.This study included 205 patients divided into three groups:(1)patients who underwent major outpatient surgery(n=57);(2)patients with non-surgical abdominal pain(NSAP)in whom the diagnosis of PAA was excluded(n=53),and(3)patients with a confirmed diagnosis of PAA(n=95).The PAA patients were further classified as uncomplicated or complicated PAA.IL-6 concentration was determined in all patients at diagnosis.Comparative statistical analysis was performed using the Mann-Whitney U test,the Fisher exact test and the Kruskall Wallis test.The area under the receiver operating characteristic curves(AUC)were calculated.Results Median(interquartile range,IQR)serum IL-6 values were 2 pg/mL(2.0–3.4)in group 1,3.9 pg/mL(2.4–11.9)in group 2,and 23.9 pg/mL(11.1–61.0)in group 3(P<0.001).Among the participants in group 3,those with uncomplicated PAA had median(IQR)serum IL-6 values of 17.2 pg/mL(8.5–36.8),and those with complicated PAA had 60.25 pg/mL(27.1–169)serum IL-6(P<0.001).At the cut-off point of 19.55 pg/mL,the AUC for the discrimination between patients in group 2 vs.3 was 0.83[95%confidence interval(CI)0.76–0.90],with a sensitivity of 61.3%and a specificity of 86.8.The AUC for the discrimination between patients with uncomplicated and complicated PAA was 0.77(95%CI 0.68–0.86)and the cut-off point was 25.90 pg/mL,with a sensitivity and specificity of 84.6%and 65.6%,respectively.Conclusions Serum IL-6 has a good performance in discerning between complicated and uncomplicated PAA.A score including clinical and radiological variables may increase the diagnostic performance of this molecule. | Javier Arredondo Montero Giuseppa Antona Adriana Rivero Marcotegui Carlos BardajíPascual Mónica Bronte Anaut Raquel Ros Briones Amaya Fernández-Celis Natalia López-Andrés Nerea Martín-Calvo | 2022 | World Journal of Pediatrics2022，18，12： | 0 |
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