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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Phase 1 and pharmaco- dynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed a- cute leukemia显示文摘 | Marcucci G Byrd J C Dai G | 2003 | Blood2003，101，2： | 1 |
| 3 | Patient-level meta-analysis: effect of measurement timing, threshold, and patient age on ability of D-dimer testing to assess recurrence risk after unprovoked venous thromboembolism显示文摘 | Douketis J Tosetto A Marcucci M | 2010 | Ann Intern Med2010，153，8： | 1 |
| 4 | Free fatty acid-in- duced insulin resistance is associated with activation of protein ki- nase C theta and alterations in the insulin signaling cascade 显示文摘 | Griffin M E Marcucci M J Cline G W | 1999 | Diabetes1999，48，6： | 1 |
| 5 | Forecasting Stock Market Volatility with Regime-switching GARCH Models 显示文摘 | Marcucci J | 2005 | Studies in Nonlinear Dynamics & Econometrics2005，9，4： | 1 |
| 6 | Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade显示文摘 | Griffin M E Marcucci M J Cline G W | 1999 | Diabetes1999，48，： | 1 |
| 7 | Free fatty acid induced insulin resistance is associated with activation of protein kinase C and alterations in the insulin signaling cascade显示文摘 | Griffin M E Marcucci M J Gary W | 1999 | DIABETES1999，48，： | 1 |
| 8 | Risk ofrecurrence after venous thromboembolism in men andwomen:patient level meta-analysis显示文摘 | DOUKETIS J TOSETTO A MARCUCCI M | 2011 | BMJ2011，342，： | 1 |
| 9 | Phase 1 and pharmacodyna- mic studies of G3139 ,a Bc1-2 antiscnse oligonucleotide,in combina- tion with chemotherapy in refractory or relapsed acute leukemia 显示文摘 | MARCUCCI G BYRD J C DAI G | 2003 | Blood2003，101，2： | 1 |
| 10 | Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8 mediated apoptosis and down-regulation of c-FLIP protein显示文摘 | Aron J L Parthun M R Marcucci G | 2003 | Blood2003，102，2： | 1 |
| 11 | Benefits and Challenges of Linking Green Infrastructure anti Highway Planning in the United States显示文摘 | Marcucci D J Jordan L M | 2013 | Environmental Management2013，51，： | 1 |
| 12 | Risk of recur- rence after venous thromboembolism in men and women: patient level meta-analysis显示文摘 | Douketis J Tosetto A Marcucci M | 2011 | BMJ2011，342，： | 1 |
| 13 | Patient-level metaanalysis : effect of measurement timing,threshold,and patient age on ability of D-dimer testing to assess recur-rence risk after unprovoked venous thromboembolism 显示文摘 | DOUKETIS J TOSETTO A MARCUCCI M | 2010 | Ann Intern Med2010，153，8： | 1 |
| 14 | Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade 显示文摘 | Marcucci M J Cline GW | 1999 | Diabetes1999，48，6： | 1 |
| 15 | Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade 显示文摘 | Griffin ME Marcucci M J Cline GW | 1999 | Dia- betes1999，48，6： | 1 |
| 16 | Free fatty acid induced insulin resistance is associated with accitvation of protein kinase C and alterations in the insulin signaling csscade显示文摘 | Griffin ME Marcucci M J Cline GW | | 0，，06： | 1 |
| 17 | Free fatty acids-induced insulin resistance is associated with activation of Drotein kinase C theta and alterations in the insulin signaling cascade显示文摘 | Griffin M E Marcucci M J Cline G W | 1999 | diabetes1999，48，6： | 1 |
| 18 | Iron catalyst for the head-to-head dimerization of a-olefins and mechanistic implications for the production of line a-olefins显示文摘 | Small B L Marcucci A J | 2001 | Organometalic2001，20，26： | 1 |
| 19 | Forecasting stock market volatility with regime-switching GARCH models显示文摘 | Marcucci J | | 0，，： | 1 |
| 20 | Pollen and pollination experiments显示文摘 | Van Tuyl J M Clara marcucci M Visser T | | 0，，： | 1 |
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