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| 1 | 早期将抗生素由静脉转为口服治疗严重社区获得性肺炎:多中心随机试验显示文摘目的比较早期由静脉转换成口服抗生素与常规静脉使用7天抗生素治疗严重社区获得性肺炎(CAP)的疗效。设计多中心随机对照试验。地点荷兰5家教学医院和2所大学的医学中心。参加者非 ICU 住院的严重 CAP 患者302例,其中265例满足研究要求。干预静脉抗生素治疗3天,病情稳定后换成口服抗生素,或静脉使用抗生素治疗7天。主要评价结果临床治愈和住院天数。结果 302例患者被随机分组(平均年龄69.5岁,标准差14.0),肺炎严重度评分平均112.7(26.0)。37例患者因为提前3天退出而未纳入分析,对其余265例患者进行分析研究。第28天的死亡率在干预组是4%,对照组是6%(平均差2%,95%可信区间-3%~8%)。临床治愈率在干预组是83%,对照组是85%(2%;-7%~10%)。与对照组相比,干预组患者静脉治疗时间为3.4天[3.6(1.5)比7.0(2.0)天;2.8~3.9],患者住院天数减少1.9天[9.6(5.0)比11.5(4.9)天;0.6~3.2]。结论早期将抗生素由静脉应用转换成口服治疗严重 CAP 是安全的,并且可以减少住院时间2天。试验注册号临床试验 NCT00273676。 | Jan Jelrik Oosterheert Marc J M Bonten Margriet M E Schneider Erik Buskens Jan-Willem J Lammers Willem M N Hustinx Mark H H Kramer Jan M Prins Peter H Th J Slee Karin Kaasjager Andy I M Hoepelman 王伟巍(译) 童朝辉(校) | 2007 | 英国医学杂志中文版2007，10，2： | 1 |
| 2 | Confinement of NaAlH4 in Nanoporous Carbon:Impact on H2 Release, Reversibility, and Thermodynamics显示文摘 | Gao JinBao Philipp Adelhelm Margriet Margriet H W Verkuijlen | 2010 | Journal of Physical Chemistry C2010，114，： | 1 |
| 3 | Assessing Comprehension of Spoken Language in Nonspeaking Children with Cerebral Palsy:Application of a Newly Developed Computer-Based Instrument显示文摘 | JOKE J. M. Geytenbeek Margriet M. J. Heimb R.Jeroen Vermeulen | | 0，，02： | 1 |
| 4 | Protein intake and body weight regulation 显示文摘 | Margriet SW Manuela PGM | 2005 | Appetite2005，45，2： | 1 |
| 5 | Prediction of response to endoscopic therapy of Barrett’s dysplasia by using genetic biomarkers显示文摘 | Margriet R. Timmer Shannon M. Brankley Emmanuel C. Gorospe Gang Sun Lori S. Lutzke Prasad G. Iyer Kevin C. Halling Kausilia K. Krishnadath Kenneth K. Wang | 2014 | Gastrointestinal Endoscopy2014，，： | 1 |
| 6 | Effects of recurrent major de pressive disorder on behavior and cognitive function in female depressed patients显示文摘 | Indrag KL Margriet MS Thea JH | 2004 | PsycMatry Research2004，125，： | 1 |
| 7 | The acute effects of a lunch con- taining capsaicin on energy and substrate utilization,hormones,and satiety显示文摘 | Astrid J Smeets Margriet S | 2009 | Eur j nutr2009，，48： | 1 |
| 8 | Wavelet analysis of rainfall-runoff variability isolating climatic from anthropogenic patterns显示文摘 | MARGRIET N | 1999 | Environmental Modelling & Software1999，14，4： | 1 |
| 9 | Quantification of in Vivo Oxidative Damage in Caenorhabditis Elegans During Aging By Endogenous F3- isoprostane Measurement显示文摘 | Christiaan F Labuschagne Edwin C A Stigter Margriet M W B Hendriks | 2013 | Aging Ce112013，12，2： | 1 |
| 10 | Wavelet analysis of rainfall-runoff variability isolating climatic from anthropogenic pat- terns 显示文摘 | Margriet Nakken | 1999 | Environmental Modelling Software1999，14，： | 1 |
| 11 | Wavelet analysis of rainfall-runoff variability isolating climatic from anthropogenic pattems 显示文摘 | Margriet Nakken | 1999 | Environmental Modelling & Software1999，14，： | 1 |
| 12 | Characteristics of the initial seizure in familial febrile seizures显示文摘 | Margriet van Stuijvenberg E van Beijeren N H Wils | 1999 | Archives of Disease in Childhood1999，80，2： | 1 |
| 13 | Temperature, age and recurrence of febrile seizure显示文摘 | Margriet van Stuijvenberg Ewout W Steyerberg Gerarada Derksen- Lubsen | 1998 | Archives of Pediatrics & Adolescent Medicine1998，152，12： | 1 |
| 14 | Study protocol:population screening for colorectal cancer by colonoscopy or CT colonography:a randomized controlled trial显示文摘 | Thomas R de Wijkerslooth Margriet C | 2010 | BMC gastroenterology2010，10，： | 1 |
| 15 | Silane ligand exchange to make Hydrophobic superparamagnetic nanoparticles water-dispersible显示文摘 | Randy De Palma Sara Peeters Margriet J Van Bael | 2007 | Chem Mater2007，19，： | 1 |
| 16 | Hypothalamic–Pituitary–Adrenal (HPA) axis functioning in relation to body fat distribution显示文摘 | FemkeRutters Arie G.Nieuwenhuizen Sofie G. T.Lemmens Jurriaan M.Born Margriet S.Westerterp‐Plantenga | 2010 | Clinical Endocrinology2010，，6： | 1 |
| 17 | Effects of (?)-hydroxycitrate on net fat synthesis as de novo lipogenesis显示文摘 | Eva M.R. Kovacs Margriet S. Westerterp-Plantenga | 2006 | Physiology & Behavior2006，，4： | 1 |
| 18 | Wavelet analysis of rainfall-runoff variability isolating climate from anthropogenic patterns 显示文摘 | Margriet N | 1999 | Environmental Modelling & Software1999，14，4： | 1 |
| 19 | Efficient fragment coupling approaches toward large oxacalixarenes (n 6, 8)显示文摘 | WIM V R MARGRIET O LUC V M | 2009 | OrgLett2009，11，8： | 1 |
| 20 | Wavelet analysis of rainfall-runoff variabilityisolating climatic from anthropogenic patterns显示文摘 | Margriet Nakken | 1999 | Environmental Modelling & Software1999，14，： | 1 |
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