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| 1 | Anti-oxidation actions of curcumin in two forms of bed rest:oxidative stress serum and salivary markers显示文摘Objective:To determine the preventive effects of curcumin on peroxidative damage under two bed rest conditions.Methods:20 healthy male(10 with curcumin and 10 without curcumin ) volunteers were selected.They were studied before,during,and just on bed rest conditions at -6°head-down-tilt(HDT) bed rest and bed rest position(BD) for 10 days.We measured the salivary and serum oxidative markers such as Malonaldehyde,8-hydroxydeoxyguanosine, vitamin C and E just before HDT & BD.during HDT & BD experiment,and in course time of recovery with curcumin and without curcumin groups.Results:The values of serum and salivary vitamin C & E showed statistically significant decrease in both bed rest conditions as compared to those of the conditions before and during the recovery stage.However,these levels were not significantly lowered in curcumin groups in contrast to the groups without curcumin (P>0.05).MDA and 8-OHdG levels showed significant increase in simulating microgravity and zero gravity conditions as compared to those before and in the recovery stage.However,these levels were lower in curcumin groups in contrast to the groups without curcumin(P<0.05).Serum and salivary correlation analysis revealed a strong and highly significant correlation for MDA. vitamin C & E and 8 dihydro-2 deoxyguanosine(8-OHdG) in the conditions before,during and in the recovery periods in both bed rest conditions.Since saliva collection is easy and noninvasive, measurements of salivary marker levels may prove to be useful in the space research. Conclusions:Curcumin prevents peroxidative damage in both bed rest conditions.Further study is required on antioxidation actions of curcumin in space microgravity conditions. | Balwant Rai Jasdeep Kaur Maria Catalina | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，8： | 9 |
| 2 | Portal hypertensive colopathy is associated with portal hypertension severity in cirrhotic patients显示文摘AIM:To assess the prevalence of portal hypertension (PH) related colorectal lesions in liver transplant candidates, and to evaluate its association with the severity of PH.METHODS: Between October 2004 and December 2005, colonoscopy was performed in 92 cirrhotic liver transplant candidates. We described the lesions resulting from colorectal PH and their association with the grade of PH in 77 patients who underwent measurement of hepatic venous pressure gradient (HVPG).RESULTS: Mean age was 55 years and 80.7% of patients were men. The main etiology of cirrhosis was alcoholism (45.5%). Portal hypertensive colopathy (PHC) was found in 23.9%, colonic varices in 7.6% and polyps in 38% of patients (adenomatous type 65.2%). One asymptomatic patient had a well-differentiated adenocarcinoma. The manifestations of colorectal PH were not associated with the etiology of liver disease or with the Child-Pugh grade. Ninety percent of patients with colopathy presented with gastroesopha-geal varices (GEV), and 27.5% of patients with GEV presented with colopathy (P=0.12). A relationship between higher values of HVPG and presence of col-opathy was observed (19.9±6.2 mmHg vs 16.8±5.4 mmHg, P=0.045), but not with the grade of col-opathy (P=0.13). Preneoplastic polyps and neoplasm (P=0.02) and spontaneous bacterial peritonitis (P=0.006) were more prevalent in patients with colopathy. We did not observe any association between previous β-blocker therapy and the presence of colorectal portal hypertensive vasculopathy.CONCLUSION: PHC is common in cirrhotic liver trans-plant candidates and is associated with higher portal pressure. | Antonio Diaz-Sanchez Oscar Nuez-Martinez Cecilia Gonzalez-Asanza Ana Matilla Beatriz Merino Diego Rincon Inmaculada Beceiro Maria Vega Catalina Magdalena Salcedo Rafael Baares Gerardo Clemente | 2009 | World Journal of Gastroenterology2009，15，38： | 6 |
| 3 | Efficacy and Safety of Anticoagulation on Patients With Cirrhosis and Portal Vein Thrombosis显示文摘 | María Gabriela Delgado Susana Seijo Ismael Yepes Linette Achécar Maria Vega Catalina ángeles García–Criado Juan G. Abraldes Joaquín de la Pe?a Rafael Ba?ares Agustín Albillos Jaume Bosch Juan Carlos García–Pagán | 2012 | Clinical Gastroenterology and Hepatology2012，，7： | 3 |
| 4 | Pericytes synthesize renin显示文摘AIM: To investigate renin expression in pericytes during normal kidney development and after deletion of angiotensinogen, the precursor for all angiotensins.METHODS: We examined the distribution of renin expressing cells by immunoshistochemistry in the interstitial compartment of wild type(WT) and angiotensinogen deficient(AGT-/-) mice at different developmental stages from embryonic day 18(E18: WT, n = 4; AGT-/-, n = 5) and at day 1(P1: WT, n = 5; AGT-/-, n = 5), 5(P5: WT, n = 7; AGT-/-, n = 8), 10(P10: WT, n = 3; AGT-/-, n = 5), 21(P21: WT, n = 7; AGT-/-, n = 5), 45(P45: WT, n = 3; AGT-/-, n = 3), and 70(P70: WT, n = 2; AGT-/-, n = 2) of postnatal life. We quantified the number of pericytes positive for renin at all the developmental stages mentioned above and comparedthe results of AGT-/- mice to their WT counterparts.RESULTS: In WT mice, renal interstitial pericytes synthesize renin in early life supporting a lineage relationship with renin cells in the vasculature. The number of pericytes positive for renin per area of 0.32 mm2(density) in WT mice was maintained from fetal life till weaning age(E18 = 4.25 ± 0.63, P1 = 3.75 ± 0.48, P5 = 3.75 ± 0.48, P10 = 4 ± 0.71, P21 = 3.8 ± 0.58) and markedly decreased in adult life(P45 = 1.2 ± 0.37, P70 = 0.8 ± 0.20). On the other hand, in AGT-/- mice the density of pericytes expressing renin was not significantly different from WT mice at E18 and P1: E18 = 5.75 ± 0.50 vs 4.25 ± 0.63(P = 0.106), P1 = 9.25 ± 3.50 vs 3.75 ± 0.48(P = 0.175) but significantly increased from P5 till P70: P5 = 38.25 ± 5 vs 3.75 ± 0.48(P = 0.0004), P10 = 173 ± 7.50 vs 4 ± 0.70(P = 5.24567 × 10-7), P21 = 83 ± 6.70 vs 3.8 ± 0.58(P = 2.97358 × 10-6), P45 = 49 ± 3.50 vs 1.2 ± 0.37(P = 8.18274 x 10-7) and P70 = 17.8 ± 2.30 vs 0.8 ± 0.20(P = 3.51151 × 10-5). The AGT-/- mice showed a marked increase in the number of pericytes per field studied starting from P5, reaching its peak at P10, and then a gradually decreasing until P70. CONCLUSION: Interstitial pericytes synthesize renin during development and the number of renin-expressing pericytes increases in response to a homeostatic threat imposed early in life such as lack of angiotensinogen. | Alison C Berg Catalina Chernavvsky-Sequeira Jennifer Lindsey R Ariel Gomez Maria Luisa S Sequeira-Lopez | 2013 | World Journal of Nephrology2013，2，1： | 2 |
| 5 | In situ measurement of trace metals in lake water using the dialysis and DGT techniques显示文摘 | Maria Catalina Alfaro-De la Torre Pierre-Yves Beaulieu André Tessier | 2000 | Analytica Chimica Acta2000，418，1： | 1 |
| 6 | Elicitation of peroxidase activity and lignin biosynthesis in pepper suspension cells by Phytophthora capsici显示文摘 | Catalina Egea Ahmed Sid Ahmed Milagros Candela Maria Emilia Candela | 2001 | Journal of Plant Physiology2001，，2： | 1 |
| 7 | 1,2,4,5- Benzcnetetracarboxylic acid and 4,4'-bipyridine as lig- ands in dcsining low-dimensional coordination polymers 显示文摘 | Catalina R P Pablo L L Maria H M | 2004 | Eur J Inorg Chem2004，，： | 1 |
| 8 | Efficacy and Safety of Anticoagulation on Patients With Cirrhosis and Portal Vein Thrombosis显示文摘 | María Gabriela Delgado Susana Seijo Ismael Yepes Linette Achécar Maria Vega Catalina ángeles García–Criado Juan G. Abraldes Joaquín de la Pe?a Rafael Ba?ares Agustín Albillos Jaume Bosch Juan Carlos García–Pagán | 2012 | Clinical Gastroenterology and Hepatology2012，，7： | 1 |
| 9 | Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats显示文摘 | Maria Angeles Rosillo Marina Sánchez-Hidalgo Ana Cárdeno Marina Aparicio-Soto Susana Sánchez-Fidalgo Isabel Villegas Catalina Alarcón de la Lastra | 2012 | Pharmacological Research2012，，： | 1 |
| 10 | Development of a sandwich enzyme linked immunosorbent assay (ELISA) for the quantification of iduronate-2-sulfate sulfatase显示文摘 | Angela Catalina Sosa Angela Johana Espejo Edwin Alexander Rodriguez Lina Maria Lizaraso Andrea Rojas Johana Guevara Olga Yaneth Echeverri Luis Alejandro Barrera | 2011 | Journal of Immunological Methods2011，，1： | 1 |
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