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| 1 | Diabetic nephropathy:Is it time yet for routine kidney biopsy?显示文摘Diabetic nephropathy(DN)is one of the most important long-term complications of diabetes.Patients with diabetes and chronic kidney disease have an increased risk of all-cause mortality,cardiovascular mortality,and kidney failure.The clinical diagnosis of DN depends on the detection of microalbuminuria.This usually occurs after the first five years from the onset of diabetes,and predictors of DN development and progression are being studied but are not yet implemented into clinical practice.Diagnostic tests are useful tools to recognize onset,progression and response to therapeutic interventions.Microalbuminuria is an indicator of DN,and it is considered the only noninvasive marker of early onset.However,up to now there is no diagnostic tool that can predict which patients will develop DN before any damage is present.Pathological renal injury is hard to predict only with clinical and laboratory findings.An accurate estimate of damage in DN can only be achieved by the histological analysis of tissue samples.At the present time,renal biopsy is indicated on patients with diabetes under the suspicion of the presence of nephropathies other than DN.Results from renal biopsies in patients with diabetes had made possible the classification of renal biopsies in three major groups associated with different prognostic features:diabetic nephropathy,non-diabetic renal disease(NDRD),and a superimposed non-diabetic condition on underlying diabetic nephropathy.In patients with type 2 diabetes with a higher degree of suspicion for NDRD,it is granted the need of a renal biopsy.It is important to identify and differentiate these pathologies at an early stage in order to prevent progression and potential complications.Therefore,a more extensive use of biopsy is advisable. | Maria L Gonzalez Suarez David B Thomas Laura Barisoni Alessia Fornoni | 2013 | World Journal of Diabetes2013，4，6： | 29 |
| 2 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 3 | Circulating miR-29a, Among Other Up-Regulated MicroRNAs, Is the Only Biomarker for Both Hypertrophy and Fibrosis in Patients With Hypertrophic Cardiomyopathy显示文摘 | Roberta Roncarati Chiara Viviani Anselmi Maria Angela Losi Laura Papa Elena Cavarretta Paula Da Costa Martins Carla Contaldi Gloria Saccani Jotti Anna Franzone Laura Galastri Michael V.G. Latronico Massimo Imbriaco Giovanni Esposito Leon De Windt Sandro B | 2014 | Journal of the American College of Cardiology2014，，9： | 2 |
| 4 | A study of the retrograda- tion process in five argentine rice starches显示文摘 | LAURA B I de MISHIMA B L MARIA C A | 2010 | LWT-Food Science and Technology2010，43，4： | 1 |
| 5 | A small molecule targeting the multifactorial nature of Alzheimer's disease 显示文摘 | Andrea C Maria Laura B Simona C | 2007 | Angew Chemi Int Engl2007，46，20： | 1 |
| 6 | A study of the retrogradation process in five argentine rice starches显示文摘 | LAURA B ITURRIAGA BEATRIZ LOPEZ DE MISHIMA MARIA C ANON | 2009 | LWT - Food Science and Technology2009，43，4： | 1 |
| 7 | Chemoselective hy- drogenation of halonitroaromatics over ?-Fe203-supported platinum nanoparticles: The role of the support on their catalytic activity and selectivity显示文摘 | Claudio E Laura A A Maria B | 2013 | J Mol Catal A: Chem2013，366，： | 1 |
| 8 | Immunosuppression Interleukin-10 Synthesis and Apoptosis are Induced in Rats Inoculated with Cryptococcus Neoformans Glucuronoxylomanna显示文摘 | LAURA S C JOSE L B MARIA P A | 2004 | Immunology2004，113，： | 1 |
| 9 | Molecular mecha- nisms of fluoride toxicity 显示文摘 | OLIVIER B LAURA A M LUZ MARIA D R | 2010 | Chemico-Biological Interactions2010，188，2： | 1 |
| 10 | Aflatoxin M1 determination in raw milk using a flow-injection immunoassay system显示文摘 | Mihaela B Laura M Maria CM | 2004 | Analytica Chimica Acta2004，520，12： | 1 |
| 11 | Atrial natriuretic peptide modifies arterial blood pressure through nitric oxide pathway in rats显示文摘 | Maria A C Laura V G B Monica P M | 2000 | Hypertension2000，35，： | 1 |
| 12 | Quereetin induces ap- optosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-Kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2) 显示文摘 | Ana Belen GS Maria AM Laura B | 2006 | JNutr2006，136，11： | 1 |
| 13 | HPLC -F analysis of me- latonin and resveratrol isomers in wine using an SPE procedure 显示文摘 | Laura M Maria AS Francesca B | 2008 | J Separ Sci2008，31，67： | 1 |
| 14 | 查看详情显示文摘 | RAQUEL A MARIA J B LAURA C | | 0，，24： | 1 |
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