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| 1 | Safety and feasibility of thullium laser transurethral resection of prostate for the treatment of benign prostatic enlargement in overweight patients显示文摘Objective:We aimed to determine safety and feasibility of thulium laser transurethral vapoenucleation of prostate(ThuVEP)for treatment of obese patients affected by benign prostatic hyperplasia(BPH).Methods:We retrospectively analysed data of 452 patients with BPH who underwent ThuVEP from February 2012 to March 2016 in a single center.Patients were divided into three groups according to body mass index(BMI,kg/m^2):Normal weight(18.5≤BMI<25;Group A),overweight(25≤BMI<30;Group B)and obese(BMI≤30;Group C),for a total of 412 patients evaluable for this study.Preoperative total serum prostate-specific antigen(PSA),digital rectal examination of the prostate,transrectal ultrasound(TRUS),renal ultrasound,urine culture,uroflowmetry,International Prostate Symptoms Score(IPSS),and Quality of Life(QoL)score were analyzed.Post-operative complications,hospital stay and days of catheterization,questionnaires and uroflowmetry at 1 and 3 months after surgery were evaluated.Preoperative data,surgical outcomes,complication rate and clinical outcomes were compared between groups.Results:The median age of patients was 69 years(Interquartile Range[IQR 10]).The preoperative median IPSS among groups was 19(IQR 8.75),20(IQR 10),and 18(IQR 10)respectively.At 1 and 3 months of follow-up,this value was 8(IQR 7),8(IQR 4),7(IQR 5)and 5(IQR 6.25),5(IQR 6),6(IQR 5),respectively(all p between groups>0.05).There was no statistically significant difference among three groups as for hospital stay and days of catheterization(p>0.05).Conclusion:Our results showed that ThuVEP was safe and feasible even in overweight patients with substantially enlarged prostate. | Luca Carmignani Maria Chiara Clementi Claudia Signorini Gloria Motta Sebastiano Nazzani Franco Palmisano Elisa De Lorenzis Michele Catellani Alessandro Francesco Mistretta Andrea Conti Valeria Tringali Maria Beatrice Costa Damiano Vizziello | 2019 | Asian Journal of Urology2019，6，3： | 3 |
| 2 | Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with <50copies/ml HIV-1 RNA显示文摘 | Silvia Baroncelli Clementina Maria Galluzzo Maria Franca Pirillo Maria Grazia Mancini Liliana Elena Weimer Mauro Andreotti Roberta Amici Stefano Vella Marina Giuliano Lucia Palmisano | 2009 | Journal of Clinical Virology2009，，： | 1 |
| 3 | Investigantion of HLA class I downregulation in breast cancer by RT-PCR显示文摘 | Guilio L Palmisano Maria P P | 2001 | Hum Immunol2001，62，： | 1 |
| 4 | Structure-tissue exposure/selectivity relationship(STR) correlates with clinical efficacy/safety显示文摘Drug optimization, which improves drug potency/specificity by structure-activity relationship(SAR) and drug-like properties, is rigorously performed to select drug candidates for clinical trials. However,the current drug optimization may overlook the structure-tissue exposure/selectivity-relationship(STR) in disease-targeted tissues vs. normal tissues, which may mislead the drug candidate selection and impact the balance of clinical efficacy/toxicity. In this study, we investigated the STR in correlation with observed clinical efficacy/toxicity using seven selective estrogen receptor modulators(SERMs) that have similar structures, same molecular target, and similar/different pharmacokinetics. The results showed that drug’s plasma exposure was not correlated with drug’s exposures in the target tissues(tumor, fat pad, bone, uterus),while tissue exposure/selectivity of SERMs was correlated with clinical efficacy/safety. Slight structure modifications of four SERMs did not change drug’s plasma exposure but altered drug’s tissue exposure/selectivity.Seven SERMs with high protein binding showed higher accumulation in tumors compared to surrounding normal tissues, which is likely due to tumor EPR effect of protein-bound drugs. These suggest that STR alters drug’s tissue exposure/selectivity in disease-targeted tissues vs. normal tissues impacting clinical efficacy/toxicity. Drug optimization needs to balance the SAR and STR in selecting drug candidate for clinical trial to improve success of clinical drug development. | Wei Gao Hongxiang Hu Lipeng Dai Miao He Hebao Yuan Huixia Zhang Jinhui Liao Bo Wen Yan Li Maria Palmisano Mohamed Dit Mady Traore Simon Zhou Duxin Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 5 | Ten-year experience with penile prosthetic surgery for the treatment of erectile dysfunction:outcomes of a tertiary referral center and predictors of early prosthetic infection显示文摘We aimed to evaluate ten-year outcomes of penile prosthesis(PP)implantation for the treatment of erectile dysfunction and to assess predictors of early prosthetic infection(EPI).We identified 549 men who underwent 576 PP placements between 2008 and 2018.Univariate and multivariate analyses were used to identify potential predictors of EPI.An EPI predictive nomogram was developed.Thirty-five(6.1%)cases of EPI were recorded with an explant rate of 3.1%.In terms of satisfaction,82.0%of the patients defined themselves as“satisfied,”while partner’s satisfaction was 88.3%.Diabetes(P=0.012),longer operative time(P=0.032),and reinterventions(P=0.048)were associated with EPI risk,while postoperative ciprofloxacin was inversely associated with EPI(P=0.014).Rifampin/gentamicin-coated 3-piece inflatable PP(r/g-c 3IPP)showed a higher EPI risk(P=0.019).Multivariate analyses showed a two-fold higher risk of EPI in diabetic patients,redo surgeries,or when a r/g-c 3IPP was used(all P<0.03).We showed that diabetes,longer operative time,and secondary surgeries were the risk factors for EPI.Postoperative ciprofloxacin was associated with a reduced risk of EPI,while r/g-c 3IPP had higher EPI rates without an increased risk of PP explant.After further validation,the proposed nomogram could be a useful tool for the preoperative counseling of PP implantation. | Franco Palmisano Luca Boeri Riccardo Ievoli Josvany Sánchez-Curbelo Matteo Giulio Spinelli Andrea Gregori Antonio Maria Granata Eduard Ruiz-Castane Emanuele Montanari Joaquim Sarquella-Geli | 2022 | Asian Journal of Andrology2022，24，1： | 1 |
| 6 | Commentary on “Clinical outcome of pediatric and young adult subclinical varicoceles: a single-institution experience”显示文摘We read with interest the study by Cho et al.1 regarding the features of subclinical varicocele in a pediatric and young adult single-center population.Out of 98 patients identified,the majority had a rightsided subclinical varicocele(69%,n=25),usually with a contralateral clinical varicocele.Testicular asymmetry(>20%volume difference of the affected side by testicular atrophy index formula)was assessed in nine patients with unilateral subclinical varicocele without contralateral varicocele,either clinical or subclinical.Interestingly,of 17 patients with a mean follow-up of 32 months,3(17.6%)progressed to clinical varicocele without asymmetric testicular volume,as most remained subclinical or had subsequent resolution by ultrasound.The authors concluded that subclinical varicoceles appeared unlikely to progress to a clinical disease,to affect testicular volume,or to lead to surgery. | Franco Palmisano Michele Talso Antonio Maria Granata Andrea Gregori | 2021 | Asian Journal of Andrology2021，23，6： | 0 |
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