|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatitis B and inflammatory bowel disease: Role of antiviral prophylaxis显示文摘Hepatitis B virus (HBV) is a very common infection worldwide. Its reactivation in patients receiving immunosuppression has been widely described as being associated with significant morbidity and mortality unless anti-viral prophylaxis is administered. Treatment in inflammatory bowel disease (IBD) patients has changed in recent years and immunosuppression and biological therapies are now used more frequently than before. Although current studies have reported an incidence of hepatitis B in inflammatory bowel disease patients similar to that in the general population, associated liver damage remains an important concern in this setting. Liver dysfunction may manifest in several ways, from a subtle change in serum aminotransferase levels to fulminant liver failure and death. Patients undergoing double immunosuppression are at a higher risk, and reactivation usually occurs after more than one year of treatment. As preventive measures, all IBD patients should be screened for HBV markers at diagnosis and those who are positive for the hepatitis B surface antigen should receive antiviral prophylaxis before undergoing immunosuppression in order to avoid HBV reactivation. Tenofovir/entecavir are preferred to lamivudine as nucleos(t)ide analogues due to their better resistance profile. In patients with occult or resolved HBV, viral reactivation does not appear to be a relevant issue and regular DNA determination is recommended during immunosuppression therapy. Consensus guidelines on this topic have been published in recent years. The prevention and management of HBV infection in IBD patients is addressed in this review in order to address practical | Pilar López-Serrano Jose Lázaro Pérez-Calle Maria Dolores Sánchez-Tembleque | 2013 | World Journal of Gastroenterology2013，19，9： | 12 |
| 2 | Effect of initial material bulk density and easily-degraded organic matter content on temperature changes during composting of cucumber stalk显示文摘To inactivate the potentially pathogenic microorganisms and safely utilize vegetable waste compost, ultra-high temperatures(> 70°C) should be maintained during the composting without having an inhibitory effect on maturity. This study investigated the influence of bulk density(part 1) and easily-degraded organic matter content(EDOMC, part 2) on temperature evolution during vegetable waste composting: Part 1: corn straw with different particle sizes was used to achieve different bulk densities in the composting material(BD1–BD3); Part 2: partial or total substitution of the corn straw by corn starch was carried out to obtain different EDOMC(ED1–ED4). The composting experiments were conducted in a labscale reactor(1.75 kg material) and lasted for 30 d. Temperature and CO2 emission were recorded daily, and the organic matter, lignocellulose, microbial activity, germination index(GI) and C/N of the samples were measured at different stages. The highest temperature(65.7°C) in part 1 occurred in the treatment with the bulk density of 0.35 g/cm3, which also had the longest thermophilic phase. Bulk density was found to seriously influence the utilization efficiency of O2 and heat transfer through materials, rather than heat production from organic matter degradation. In experiment part 2, the highest temperature was obtained with EDOMC of 45%(71.4°C). Therefore, adjusting the bulk density to 0.35 g/cm3 and the easily-degraded organic matter content of the initial material to 45% was the best combination for reaching temperatures above 70°C during composting, with no inhibitory effect on the maturity of the compost product. | Ruixue Chang Qiuyue Guo Qing Chen Maria Pilar Bernal Qian Wang Yanming Li | 2019 | Journal of Environmental Sciences2019，31，6： | 11 |
| 3 | Current stage in inflammatory bowel disease: What is next?显示文摘In recent years,the incidence of inflammatory bowel disease(IBD) has been on the rise,extending to countries where it was infrequent in the past. As a result,the gap between high and low incidence countries is decreasing. The disease,therefore,has an important economic impact on the healthcare system. Advances in recent years in pharmacogenetics and clinical pharmacology have allowed for the development of treatment strategies adjusted to the patient profile. Concurrently,new drugs aimed at inflammatory targets have been developed that may expand future treatment options. This review examines advances in the optimization of existing drug treatments and the development of novel treatment options for IBD. | Gonzalo Jesús Gómez-Gómez ángeles Masedo Carmen Yela Maria del Pilar Martínez-Montiel Begona Casís | 2015 | World Journal of Gastroenterology2015，21，40： | 6 |
| 4 | Regulatory T cells in patients with inflammatory bowel diseases treated with adacolumn granulocytapheresis显示文摘AIM: To investigate if the clinical efficacy of granulocytes and monocytes by adsorption (GMA) is associated with an increased frequency of peripheral regulatory T cells (Tregs), as these cells have proven to be successful in suppressing inflammatory bowel disease (IBD) in animal models. METHODS: We report four cases of corticosteroid- dependent ulcerative colitis (UC) and two Crohn’s disease (CD) cases with severe cutaneous lesions who received GMA therapy. The frequency of CD4+ CD25high (Tregs) in peripheral blood was analyzed by flow cytometry and the expression of FoxP3 and TGF beta in purified CD4+ T cells was determined by real time PCR prior to and one month after the last apheresis session, and at the time of endoscopic and clinical assessing. RESULTS: Increased expression of Fox P3 mRNA was found in all five patients who responded to cytapheresis with remission of clinical symptoms, mucosal inflammation and cutaneous lesions, and an increased frequency of circulating Tregs was found in four patients. These changes were not observed in the patient with UC who did no respond to GMA. Variations in TGF-β (mRNA) did not parallel that of FoxP3 mRNA. CONCLUSION: The clinical efficacy of GMA on IBD and related extra intestinal manifestations was associated with an expansion of circulating CD4+ CD25+ Tregs and higher expression of FoxP3 in CD4+ T cells. Accordingly, an elevated CD4+ CD25+ FoxP3 may be a valuable index of remission in patients with IBD and other chronic relapsing-remitting inflammatory conditions during treatment with GMA. | Emilio Cuadrado Marta Alonso Maria Dolores de Juan Pilar Echaniz Juan Ignacio Arenas | 2008 | World Journal of Gastroenterology2008，14，10： | 6 |
| 5 | Short and long term fate of human AMSC subcutaneously injected in mice显示文摘AIM:To study the ability of human adipose-derived mesenchymal stem cells(AMSCs)to survive over the short and long term,their biodistribution and their biosafety in vivo in tumor-prone environments.METHODS:We subcutaneously injected human AMSCs from different human donors into immunodeficient SCID mice over both short-(2 and 4 mo)and long-(17 mo)term in young,and aged tumor-prone mice.Presence of human cells was studied by immunohistochemistry and polymerase chain reaction analysis in all organs of injected mice.RESULTS:Subcutaneously injected AMSCs did not form teratomas at any time point.They did not migrate but remained at the site of injection regardless of animal age,and did not fuse with host cells in any organ examined.AMSCs survived in vivo for at least 17 mo after injection,and differentiated into fibroblasts of the subdermic connective tissue and into mature adipocytes of fat tissue,exclusively at the site of injection.CONCLUSION:Our results support the assertion that AMSC may be safe candidates for therapy when injected subcutaneously because of their long term inability to form teratomas. | Pilar López-Iglesias Alejandro Blázquez-Martínez Jorge Fernández-Delgado Javier Regadera Manuel Nistal Maria P De Miguel | 2011 | World Journal of Stem Cells2011，3，6： | 5 |
| 6 | Contractile effect of tachykinins on rabbit sma intestine显示文摘 | Marta Sofia VALERO Diego Santos FAGUNDES Laura GRASA Maria Pilar ARRUEBO Miguel Angel PLAZA Maria Divina MURILLO | 2011 | Acta Pharmacologica Sinica2011，32，4： | 5 |
| 7 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 8 | Differential expression of the fractalkine chemokine receptor (CX3CR 1) in human rnonocytes during differentiation显示文摘传播单核白血球(瞬间) 可以连续地使人重新住入巨噬细胞(MAC ) 或树枝状的房间(DC ) 维持动态平衡的人口。MAC 和 DC 是玩不同、互补的免疫学的功能的专业化房间。因此,他们现在的不同迁移的性质。明确地,而 MAC 大部分留在纸巾, DC 能够从外部纸巾移居到淋巴的机关。这个工作的目的是分析 fractalkine 受体的表达式(CX 3 CR1 ) 在 monocytic 区别进程期间。两 CX 3 CR1 mRNA 和蛋白质。在瞬间区别过程期间, CX 3 CR1 是在 DC 和 MAC 的 downregulated。然而, MAC 显示出显著地更高的 CX 3 CR1 表示层次比 DC。我们也观察了对抗 CX 3 由干扰素(IFN ) 的 CR1 规定 -γ并且 interleukin (IL )-4 在通过古典、其他的 MAC 小径的 MAC 激活期间分别地。IFN-γ禁止了 CX 3 CR1,而是 IL-4 导致了它。另外,我们表明了在 CX 3 由可溶的 fractalkine 的 CR1 表示和 apoptosis 预防(sCX 3 CL1 ) 在瞬间, DC 和 MAC。这是表明顺序、微分的 CX 3 CR1 调整在瞬间区别期间。最重要地,我们表明了在 CX 3 CR1 表示和房间幸存面对 sCX 3 CL1。 | Cecilia Analia Panek Maria Victoria Ramos Maria Pilar Mejias Maria Iimena Abrey-Recalde Romina Iimena Fernandez-Brando Maria Soledad Gori Gabriela Veronica Salamone2 Marina Sandra Palermo | 2015 | Cellular & Molecular Immunology2015，12，6： | 3 |
| 9 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 10 | S-adenosyl-methionine decreases ethanol-induced apoptosis in primary hepatocyte cultures by a c-Jun N-terminal kinase activity-independent mechanism显示文摘AIM:To determine the role of c-Jun N-terminal kinase(JNK)activity in ethanol-induced apoptosis and themodulation of this signaling cascade by S-Adenosyl-methionine(AdoMet).METHODS:Primary hepatocyte cultures werepretreated with 100 μmol/L SP600125,a selective JNKinhibitor,1 mL/L DMSO or 4 mmol/L AdoMet and thenexposed to 100 mmo/L ethanol.Hepatocyte apoptosiswas determined by the TUNEL and DNA ladder assays.JNK activity and its inhibition by SP600125 and AdoMetwere determined by Western blot analysis of c-junphosphorylation and Bid fragmentation.SP600125 andAdoMet effects on the apoptotic signaling pathway weredetermined by Western blot analysis of cytochrome crelease and pro-caspase 3 fragmentation.The AdoMeteffect on glutathione levels was measured by Ellman'smethod and reactive oxygen species(ROS)generationby cell cytometry.RESULTS:The exposure of hepatocytes to ethanolinduced JNK activation,c-jun phosphorylation,Bidfragmentation,cytochrome c release and pro-caspase 3cleavage;these effects were diminished by SP600125,and caused a significant decrease in ethanol-inducedapoptosis(P<0.05).AdoMet exerted an antioxidanteffect maintaining glutathione levels and decreasing ROSgeneration,without a significant effect on JNK activity,and prevented cytochrome c release and pro-caspase 3cleavage. CONCLUSION:The JNK signaling cascade is a keycomponent of the proapoptotic signaling pathwayinduced by ethanol.JNK activation may be independentfrom ROS generation,since AdoMet which exertedantioxidant properties did not have a significant effect onJNK activity.JNK pathway modulator agents and AdoMetmay be components of promising therapies for alcoholicliver disease(ALD)treatment. | Maria del Pilar Cabrales-Romero Lucrecia Márquez-Rosado Samia FatteI-Fazenda Cristina Trejo-Solis Evelia Arce-Popoca Leticia Alemán-Lazarini Saúl Villa-Trevineo | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 11 | Transient elastography to rule out esophageal varices and portal hypertensive gastropathy in HIV-infected individuals with liver cirrhosis显示文摘 | Maria L. Montes Ramirez Jose F. Pascual-Pareja Matilde Sánchez-Conde Jose I. Bernardino De la Serna Francisco X. Zamora Vargas Pilar Miralles Juan M. Castro Margarita Ramírez Isabel Gutierrez Juan Gonzalez-García Juan Berenguer Jose R. Arribas López | 2012 | AIDS2012，，14： | 1 |
| 12 | Identification, Typing, and Phylogenetic Relationships of the Main Clinical Nocardia Species in Spain According to Their gyrB and rpoB Genes显示文摘 | Gema Carrasco Sylvia Valdezate Noelia Garrido Pilar Villalón Maria J. Medina-Pascual Juan A. Sáez-Nieto | 2013 | Journal of Clinical Microbiology2013，，11： | 1 |
| 13 | Environmental risk factors in inflammatory bowel diseases. Investigating the hygiene hypothesis: A Spanish case–control study显示文摘 | Pilar López-Serrano José L. Pérez-Calle Maria Teresa Pérez-Fernández Juan Manuel Fernández-Font Daniel Boixeda de Miguel Conrado M. Fernández-Rodríguez | 2010 | Scandinavian Journal of Gastroenterology2010，，12： | 1 |
| 14 | Identification of Candida albicans exposed surface proteins in vivo by a rapid proteomic approach 显示文摘 | Maria L H Pilar X E Montserrat M G | 2010 | Proteomics2010，73，7： | 1 |
| 15 | HRP -based amperometric biosensor for the polyphenols determination in vegetables extract 显示文摘 | Lucilene Domelles Mello Maria Del Pilar Taboada Sotomayor Lauro Tatsuo Kubota | 2003 | Sensors and Actuators B:Chemical2003，96，3： | 1 |
| 16 | Factors Influencing Repeat Visits to a Destination:The Influence of Group Composition显示文摘 | Sara Campo-martinez Joan Garau-vadell Maria Pilar Martinez-vuiz | 2010 | Tourism Management2010，31，6： | 1 |
| 17 | Characterization of EVA-based adhesives containing different amounts of rosin ester or polyterpene tackifier显示文摘 | BARRUESO-MARTINEZ MARIA LUISA DEL PILAR FERRANDIZE | 2003 | Journal of Adhesion2003，79，89： | 1 |
| 18 | Asynahronous development of stigmatic re- ceptivity in the pear(Pyrus communis, Rosaceae) flower显示文摘 | Javier S Pilar R Maria H | 2003 | American Journal of Botany2003，90，1： | 1 |
| 19 | Effects of intravenous albumin in patients with cirrhosis and episodic hepatic encephalopathy: A randomized double-blind study显示文摘 | Macarena Simón-Talero Rita García-Martínez Maria Torrens Salvador Augustin Susana Gómez Gustavo Pereira Mónica Guevara Pere Ginés Germán Soriano Eva Román Jordi Sánchez-Delgado Roser Ferrer Juan C. Nieto Pilar Sunyé Inma Fuentes Rafael Esteban Juan Córdob | 2013 | Journal of Hepatology2013，，6： | 1 |
| 20 | Congenital and acquired anomalies of the portal venous systerm显示文摘 | Carmen G Maria V Pilar M | 2002 | Radiographics2002，22，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员