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| 1 | 小麦指纹图谱数据库的建立及SSR分子标记试剂盒的研发显示文摘本研究以国际玉米小麦改良中心(CIMMYT)、国际干旱地区农业研究中心(ICARDA)、法国Agropolis研究所和中国农业科学院作物科学研究所提供的数据为基础,建立了包括134个SSR引物、2457个普通小麦基因型的指纹图谱数据库。利用荧光标记法的分析结果,用代表性基因型在某一位点的扩增片段作为银染法的读带依据,开发了SSR分子标记试剂盒,包括46对SSR引物及其PCR反应程序、代表性基因型的DNA样品、592个等位变异的代表性基因型清单及试剂盒使用说明等。该数据库的建立和试剂盒的开发,为利用SSR分子标记技术进行小麦种质遗传多样性研究,实现小麦遗传资源和信息资源全球共享提供了重要工具和技术平台。 | 李根英 Susanne Dreisigacker Marilyn L.Warburton 夏先春 何中虎 孙其信 | 2006 | 作物学报2006，，12： | 64 |
| 2 | 卒中存活者体力活动和锻炼建议:美国心脏协会/美国卒中协会针对医疗专业人员的声明显示文摘目的这份科学声明为卒中存活者的体力活动和锻炼建议提供了一份证据纵览。证据提示,卒中存活者会经历体力下降(physical deconditioning)并导致久坐的生活方式。因此,本更新版科学声明旨在为医务人员提供全面的指导,使其更好地理解体力活动的益处,并为卒中存活者各个恢复阶段的锻炼方案提供推荐意见。方法写作组成员由美国心脏协会(American Heart Association,AHA)卒中委员会的科学声明监督委员会和AHA手稿监督委员会任命。作者利用系统文献综述,参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见,对现有的证据进行总结并指出目前的知识空白。结果卒中后体力活动不足非常普遍。大量证据明确支持对卒中存活者进行运动训练,包括有氧运动和力量训练。运动训练能改善功能能力、日常生活活动的执行能力以及生活质量,同时降低随后的心血管事件风险。卒中存活者的体力活动目标和锻炼方案需个体化制定以最大限度地增高长期依从性。结论写作组给出的推荐是,体力活动和锻炼方案应融入卒中存活者的治疗。卒中存活者体力活动的推动应强调低到中等强度的有氧活动、增强肌肉力量、减少久坐的生活方式以及对卒中二级预防的危险因素管理。 | Sandra A. Billinger Ross Arena Julie Bemhardt Janice J. Eng Barry A. Franklin Cheryl Mortag Johnson Marilyn MacKay-Lyons Richard F. Macko Gillian E. Mead Elliot J. Roth Marianne Shaughnessy Ada Tang 孙新亭 张通 | 2014 | 国际脑血管病杂志2014，22，10： | 80 |
| 3 | 玉米杂交种掖单13号的SSR连锁图谱构建与叶夹角和叶向值的QTL定位与分析显示文摘为了增加单位面积产量,玉米育种者已经开始了更密植更紧凑株型的选育。叶夹角和叶向值是评价玉米株型的重要指标。本研究以掖478×丹340的500个F2单株为作图群体,构建了具有138个位点的SSR标记连锁图谱,图谱总长度为1394.9cM,平均间距10.1cM。利用397个F2:3家系对叶夹角和叶向值进行QTL定位分析,结果表明:叶夹角和叶向值分别检测到6和8个QTL,累计解释表型变异41.0%和60.8%,单个QTL的贡献率在2.9%~13.6%之间。与叶夹角和叶向值有关的基因主要作用方式为加性和部分显性。此外两个性状共检测到9对上位性互作位点,表明上位性互作在叶夹角和叶向值的遗传中也起较重要的作用。 | 路明 周芳 谢传晓 李明顺 徐云碧 Marilyn Warburton 张世煌 | 2007 | 遗传2007，29，9： | 40 |
| 4 | Senome-wide Association Studies in Maize: Praise and Stargaze显示文摘 | Yingjie Xiao Haijun Liu Liuji Wu Marilyn Warburton Jianbing Yan | 2017 | Molecular Plant2017，10，3： | 27 |
| 5 | 医疗照射控制 患者健康和安全背后的微妙平衡 | Marilyn Smith | 2006 | 国际原子能机构通报2006，0，1： | 15 |
| 6 | 广西地方玉米种质和加拿大群体的遗传多样性分析显示文摘【目的】分析45份广西地方玉米品种和15份加拿大改良群体的遗传多样性,为更好地利用地方品种拓宽广西玉米种质的遗传基础提供理论依据。【方法】采用混合取样法(每个群体中随机提取4个混合样本,每个样本包括10个单株)和SSR分子标记技术进行研究。【结果】70对SSR引物在60个群体的240份样本中扩增出245条等位基因,每对引物检测出的等位基因数目为2~6条,平均每个位点3.5条。加拿大的15份群体和广西的45份地方品种分别聚为二大类群。加拿大的15份群体又可以分为硬粒型和马齿型两个亚群。在45份广西地方种质中,同样可以分为硬粒型和马齿型两个亚群;糯玉米没有单独聚类,而是分散在硬粒型类群当中。【结论】广西亚热带种质比温带的加拿大种质具有更大的遗传变异,研究这些材料的遗传多样性可更好地扩增广西玉米种质的遗传基础,对玉米育种中发现潜在突破性种质可能会起到一定的作用。 | 吴永升 李明顺 李新海 黄开健 Marilyn Warburton 刘雪 陈卫国 张世煌 | 2008 | 中国农业科学2008，41，3： | 10 |
| 7 | Evolutionary history of the flora of Mexico: Dry forests cradles and museums of endemism显示文摘墨西哥与改变的地方性的植物群被认为一个非凡的 biogeographic 区域,生物多样性的然而空间的种系发生的措施还没被估计了理解它的植物群怎么集合了形成当前的植被。neo 和 paleoendemism 的种类丰富, endemism,种系发生的差异,种系发生的 endemism 和中心的模式决心为保存在这些措施,和他们的含意之中检验差别和一致。(42%) 24360 脉管的植物种类中, 10235 是地方性的。endemism 和种系发生的 endemism 的区域在山系统在地志的复杂性的地区与干燥森林被联系,在沙漠,并且在孤立的旱生植物的植被。季节地热带的干燥森林在墨西哥被报导了的每个单个地区作为 endemism 的一个区域被识别。重要种系发生的差异是在 TransMexican 暴烈的带并且在岭 de Chiapas 限制并且发生的大多数。尤其是,包括 neo, paleo,和 superendemism 的种系发生的聚类的最高的度在极南的墨西哥被识别。最脉管的植物系分叉在中新世(5-20mya ) 当干旱环境越过世界膨胀了时。在超过百分之五十它的表面是干旱的二个很大的大陆和事实之间的墨西哥的地点赞成了使适应极端 seasonality 和干旱的热带系的建立。这些系能大概越过中美洲从诺思和南美洲移居在期间中新世并且多样化,与 neo 和 paleoendemism 的混合物说明 endemism 的区域的墨西哥的植物群的签名。 | Victoria Sosa J. Arturo De-Nova Marilyn Vasquez-Cruz | 2018 | Journal of Systematics and Evolution2018，56，5： | 10 |
| 8 | 单中心107例骨原发血管源性肿瘤临床病理分析显示文摘目的 探讨骨原发血管源性肿瘤的临床病理特征及诊断要点。方法 回顾性分析北京积水潭医院单中心107例骨原发血管源性肿瘤临床、影像学、组织学及免疫表型特点。结果 107例骨原发血管源性肿瘤中男性65例,女性42例,其中70例普通血管瘤,19例上皮样血管内皮细胞瘤,13例血管肉瘤,2例Kaposi型血管内皮细胞瘤,1例上皮样血管瘤,1例假肌源性血管内皮细胞瘤,1例Gorhams病。患者年龄3~80岁(平均39岁),接近50%血管源性肿瘤位于中轴骨及骨盆,18例为多发。影像学表现以溶骨性改变为主,可以伴不同程度的周围硬化。普通血管瘤由于形态学特点可以直接诊断,部分非普通血管瘤病例需做免疫组化证实。92%病例CD31呈阳性(33/36)和83%病例CD34呈阳性(30/36)。结论 骨原发血管源性肿瘤在中国人群中发病率与西方国家相似,血管瘤、上皮样血管内皮细胞瘤和血管肉瘤是其主要亚型。结合影像学和病理形态学特点及免疫表型,有利于骨原发血管源性肿瘤诊断。 | 丁宜 Bui Marilyn 孙晶 董荣芳 李远 宫丽华 孟淑琴 黄啸原 | 2016 | 临床与实验病理学杂志2016，32，7： | 6 |
| 9 | Cirrhotic patients and older people显示文摘The global population is aging,and so the number of older cirrhotic patients is increasing.Older patients are characterised by a risk of frailty and comorbidities,and age is a risk factor for mortality in cirrhotic patients.The incidence of nonalcoholic fatty liver disease as an aetiology of cirrhosis is increasing,while that of chronic viral hepatitis is decreasing.Also,cirrhosis is frequently idiopathic.The management of portal hypertension in older cirrhotic patients is similar to that in younger patients,despite the greater risk of treatment-related adverse events of the former.The prevalence of hepatocellular carcinoma increases with age,but its treatment is unaffected.Liver transplantation is generally recommended for patients<70 years of age.Despite the increasing prevalence of cirrhosis in older people,little data are available and few recommendations have been proposed.This review suggests that comorbidities have a considerable impact on older cirrhotic patients. | Paul Carrier Marilyne Debette-Gratien Jérémie Jacques Véronique Loustaud-Ratti | 2019 | World Journal of Hepatology2019，11，9： | 6 |
| 10 | Genomic, Transcriptomic, and Phenomic Variation Reveals the Complex Adaptation of Modern Maize Breeding显示文摘 | Haijun Liu Xiaqing Wang Marilyn L. Warburton Weiwei Wen Minliang Jin Min Deng Jie Liu Hao Tong Qingchun Pan Xiaohong Yang Jianbing Yan | 2015 | Molecular Plant2015，8，6： | 6 |
| 11 | 卫生技术评估:全球经验综述显示文摘一、《健康价值》特刊中的卫生技术评估综述近来,在药物发展和卫生管理领域中,卫生技术评估(Health Technology Assessment,HTA)引发了较多的关注和争议。这是由于HTA带来的高风险收益引起了人们的兴趣。对HTA结果的理解很大程度上取决于各主体的视角。评论家认为,目前HTA的应用还仅限于对新医疗技术进行评估以设置其使用上的限制,但更应提倡运用HTA技术达到促进资源的有效配置及改善群体健康的目的。 | John C.O'Donnell PhD Sissi V.Pham PharmD Chris L.Pashos DavidW.Miller Marilyn Dix Smith BPharm 刘庆婧 吴晶 | 2010 | 中国药物经济学2010，，1： | 4 |
| 12 | 佛罗里达涉禽羽毛的汞浓度显示文摘1987~1990年,在美国佛罗里达州奥基乔比湖及其南边的湿地收集了92只涉禽(涉水鸟)的初级飞羽或尾羽。雏鸟羽毛中汞平均浓度检定结果:玫瑰琵鹭(Ajaia ajaja)为 2.0ppm,大蓝鹭(Ardea herodias)为 3.5ppm,大白鹭(Ardea herodias occidentalis)为4.7ppm,巨白鹭(Casmerodius albus)为7.1ppm。大白鹭羽毛中汞的浓度随年龄增长而升高,雏鸟为4.7ppm,幼鸟为6.7ppm,成鸟为8.2ppm。猎食大鱼的鸟类汞浓度最高。林鹳(Mycteriaamericana)羽毛中汞平均浓度为3.3ppm。佛罗里达南部涉禽羽毛中汞浓度比所报道的亚洲涉禽羽毛中的要高。已知25只涉禽肝脏和羽毛中汞浓度。肝脏(湿重)汞浓度(Y)与羽毛汞浓度(X)的回归方程是:log(Y)=1.52log(X)-0.722,相关系数为0.84。如果成鸟羽毛中平均汞浓度达9ppm,就会出现生殖失调,正如从一项已发表的绿头鸭(Anas platyrhynchos)实验室研究成果可以推断的那样,那么,佛罗里达南部汞浓度就高得足以减少涉禽种群的繁殖力。然而,在有把握地指定羽毛中最低中毒浓度以前,需要另外进行对照研究。 | W.Nelson Beyer Marilyn Spalding Doug Morrison 寒江 | 1997 | 人类环境杂志1997，26，2： | 4 |
| 13 | 镁对镍、钴、锌、镉离子致蟾蜍胚胎毒性的影响显示文摘[目的 ]用FETAX设计 ,研究Mg2 + 对Ni2 + 、Co2 + 、Zn2 + 和Cd2 + 致Xenopus胚胎的胚胎毒性与致畸作用的影响。 [方法 ]在 7次检测中 ,分别于含Mg2 + 5个等级浓度 (0、6 2、62、62 0、62 0 0 μmol/L)的FETAX培养液中 ,设空白对照与加入NiCl2 (5 6μmol/L)、CoCl2 (180 0 μmol/L)、ZnCl2 (3 0 0 μmol/L)和CdCl2 (18μmol/L)的 2 5个组 ,每个组内的受精卵均经 5~10 1h孵育。在该检测中限定Mg2 + (62 0 μmol/L)为标准浓度。在该浓度时Ni2 + 、Co2 + 、Zn2 + 和Cd2 + 组胚胎死亡率 <10 % ,畸形率 >95 %。 [结果 ]对照组于标准浓度时平均畸形率为 (5 4± 1 3 ) % ,低于该等级的 62 μmol/L为 (3 2± 7) % ,≤ 6 2μmol/L为 10 0 %。表明Mg2 + 不足与补加可极显著地增强与降低胚胎畸形率及其严重程度与胚胎毒性 (P <0 0 0 0 1,ANO VA分析 )。 [结论 ]对此 ,推测这可能与涉及在两价金属离子转运之间的金属吸收、细胞通道或对关键性分子靶 (即DNA聚合酶 )结合的竞争有关。 | 罗圣庆 Marilyn C.Plowman Sidney M.Hopfer F.William Sunderman JR | 2002 | 环境与职业医学2002，19，1： | 4 |
| 14 | Hepatitis B infection among adults in the philippines:A national seroprevalence study显示文摘AIM:To determine the prevalence of hepatitis B surface antigen(HBsAg)seropositivity among adult Filipinos.METHODS:Testing for HBsAg was performed on serum samples from persons aged ≥ 20 years old who participated in the National Nutrition and Health Survey(NNHeS)conducted in 2003.Information on age,sex,marital status,educational attainment,employment status,and income were collected.For this study,marital status was classified as never married or otherwise(i.e.,married,divorced,separated,widowed);educational attainment was classified as high school graduate or below or at least some tertiary education;and employment status was classified as currently employed or currently unemployed.Annual income was divided into 4 quartiles in Philippine pesos(PhP):Q1,≤ PhP 53064;Q2,PhP 53065-92192;Q3,PhP 92193-173387;and Q4,≥ PhP 173388.Prevalence estimates were weighted so that they represented the general population.Social and demographic factors were correlated with HBsAg seropositivity.Multivariate analysis was used to determine independent predictors of HBsAg seropositivity.RESULTS:A total of 2150 randomly selected adults,20 years and over,out of the 4753 adult participants of NNHeS were tested for HBsAg.The HBsAg seroprevalence was 16.7%(95%CI:14.3%-19.1%),which corresponded to an estimated 7278968 persons infected with hepatitis B.There was no significant difference between males and females(17.5% vs 16.0%;P = 0.555).This corresponded to an estimated 3721775 men and 3557193 women infected with hepatitis B.The HBsAg seroprevalence peaked at age 20-39 years old,with declining prevalence in the older age groups.The only independent predictor of HBsAg seropositivity was the annual income,with persons in the highest income quartile being less likely to be HBsAg positive(age-adjusted OR = 0.51;95%CI:0.30-0.86)compared to subjects in the lowest income quartile.Sex,marital status,educational attainment,and employment status were not found to be independent predictors of HBsAg seropositivity.CONCLUSION:The high HBsAg seroprevalence among adults in the Philippines classifies the country as hyperendemic for HBV infection and appears unchanged over the last few decades. | Stephen N Wong Janus P Ong Madalinee Eternity D Labio Oscar T Cabahug Maria Lourdes O Daez Erlinda V Valdellon Jose D Sollano Jr Marilyn O Arguillas | 2013 | World Journal of Hepatology2013，5，4： | 3 |
| 15 | 图书馆罚款规定是否早该废除了显示文摘伊里娜·弗赖曼经常光顾波士顿西郊的几个图书馆。但她最钟情的还是红砖墙的多佛镇图书馆,部分原因是它所提供的独特优惠:过期归还资料不交罚款。星期六下午,弗赖曼女士及其家人前往借书处的路上时说:'这并不是钱的问题,问题是如果我把钱包忘在车里,交罚款就很不方便。而且这里的人更友好。'方便和友好就是多佛图书管理员们7年前取消罚款时意图达到的两个目标。 | Marilyn Gardner 冷迪 | 2006 | 英语文摘2006，，7： | 3 |
| 16 | Proteomic composition of the acrostyle" Novel approaches to identify cuticular proteins involved in virus-insect interactions显示文摘 | Craig Graham Webster Maelle Thillier Elodie Pirolles Bastien Cayrol Stephane Blanc Marilyne Uzest | 2017 | Insect Science2017，24，6： | 3 |
| 17 | Ribavirin:Past,present and future显示文摘Before the advent of direct acting antiviral agents(DAAs) ribavirin, associated to pegylated-interferon played a crucial role in the treatment of chronic hepatitis C, preventing relapses and breakthroughs. In the present era of new potent DAAs, a place is still devoted to the drug. Ribavirin associated with sofosbuvir alone is efficient in the treatment of most cases of G2 infected patients. All options currently available for the last difficult-to-treat cirrhotic G3 patients contain ribavirin. Reducing treatment duration to 12 wk in G1 or G4 cirrhotic compensated patients is feasible thanks to ribavirin. Retreating patients with acquired anti NS5 A resistance-associated variants using ribavirin-based strategies could be useful. The addition of ribavirin with DAAs combinations however, leads to more frequent but mild adverse events especially in cirrhotic patients. Preliminary data with interferon-free second generation DAAs combinations without ribavirin suggest that future of the drug is jeopardized even in difficult-totreat patients: The optimization of ribavirin dosage according to an early monitoring of blood levels has been suggested to be relevant in double therapy with peginterferon or sofosbuvir but not with very potent combinations of more than two DAAs. | Véronique Loustaud-Ratti Marilyne Debette-Gratien Jérémie Jacques Sophie Alain Pierre Marquet DenisSautereau Annick Rousseau Paul Carrier | 2016 | World Journal of Hepatology2016，8，2： | 3 |
| 18 | Pediatric Nd:YAG laser capsulotomy in the operating room: review of 87 cases显示文摘AIM: To report a large series of children having Nd:YAG laser capsulotomy in the operating room using the lateral decubitus position. METHODS: Medical records of children who underwent Nd:YAG laser capsulotomy in the operating room at Ann & Robert H. Lurie Children's Hospital of Chicago between September 2008 and April 2017 were reviewed. Induction of general anesthesia and intubation was performed in the supine position after which the patient was placed in lateral decubitus position. The Nd:YAG laser capsulotomy was performed using a standard protocol. At the completion of the procedure, the patient was turned back into the supine position and extubated. RESULTS: This study included 87 eyes of 60 patients. Patient's age ranged from 1 to 18 y(mean 6.4±4.1 y). In most cases(84/87, 97%), the procedure was performed under general anesthesia. In all cases, good focus on the membrane was achieved, and the procedure was performed successfully. There were no intraoperative ocular or anesthesia-related complications. CONCLUSION: When performing Nd:YAG laser capsulotomy in the operating room, the lateral decubitus position allowsan easy and safe approach without the risk of potentially devastating complications that have been associated with the previously described sitting and prone positions. | Michael Kinori Narasimhan Jagannathan Anne M Langguth Marjorie A Sasso Marilyn B Mets Bahram Rahmani Hawke Yoon Rebecca Mets-Halgrimson Sudhi P Kurup Janice L Zeid | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 19 | Infliximab Prevents Crohn’s Disease Recurrence After Ileal Resection显示文摘 | Miguel Regueiro Wolfgang Schraut Leonard Baidoo Kevin E. Kip Antonia R. Sepulveda Marilyn Pesci Janet Harrison Scott E. Plevy | 2009 | Gastroenterology2009，，2： | 2 |
| 20 | Twelve metropolitan carbon footprints: A preliminary comparative global assessment显示文摘 | Benjamin K. Sovacool Marilyn A. Brown | 2009 | Energy Policy2009，，9： | 2 |
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