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| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | Randomized comparison of coronary stent implantation under ultrasound or angiographic guidan- ce to reduce stent restenosis (OPTICUS Study) 显示文摘 | Mudra H di Mario C de Jaegere P | 2001 | Circulation2001，104，12： | 1 |
| 3 | The successive projections algorithm for spectral variable selection in classification problems 显示文摘 | Marcio J C P Roberto K H G Mario C U A | 2005 | Chemometrics and Intelligent Laboratory Systems2005，78，： | 1 |
| 4 | From glycerol to value-added products显示文摘 | Mario P Ciriminna R Kimura H | 2007 | Angewandte Chemie lnternational Edition2007，46，： | 1 |
| 5 | Investigation of surface properties of Ru-based oxide electrodes containing Ti, Ce and Nb 显示文摘 | Mario H P Santana Leonardo M Da Silva Luiz A De Faria | 2003 | Electrochimica Acta2003，48，： | 1 |
| 6 | Spatial Context and the Complexity of Daily Travel Patterns: an international comparison显示文摘 | Timmermans H P van der Waerden Mario A | 2003 | Journal of Transport Geography2003，11，： | 1 |
| 7 | What's next in transla- tional medicine?显示文摘 | Littman B H Linda D M Mario P et td | 2007 | Clin Sci2007，112，： | 1 |
| 8 | Physiological functions of beneficial elements显示文摘 | Elizabeth A H P S Colin F Q Wiebke T Mario M Michela S | 2009 | Current Opinion in Plant Biology2009，12，3： | 1 |
| 9 | A PLS regression model using NIR spectroscopy for on-line monitoring of the biodiesel production reaction显示文摘 | Mario H M K Jarbas J R R Celio P | 2011 | Fuel2011，90，： | 1 |
| 10 | A variable elimination method to improve the parsimony of MLR models using the successive projections algorithm显示文摘 | Roberto K H G Mario C U A Wallace D F Edvan C S Gledson E J Sofacles F C S Henrique M P | 2008 | Chemometrics and Intelligent Laboratory Systems2008，92，： | 1 |
| 11 | Effect of preparation procedure of IrO2- Nb2O5 anodes on surface and electrocata- lytic properties 显示文摘 | Mario H P Santana Luiz A | 2005 | Journal of Applied Electrochemistry2005，35，： | 1 |
| 12 | Randomized comparison of coronary stent implantation under ultrasound or angiographic guidance to reduce stent restenosis (OPTICUS Study)显示文摘 | di Mario C de Jaegere P Figulla H Macaya C Zahn R | 2001 | Circulation2001，104，： | 1 |
| 13 | First STEP process modeler- a CIMOSA-compliant modeling tool显示文摘 | Meir H Levi Marios P Klapsis | 1999 | Computers in Industry1999，40，： | 1 |
| 14 | Rand-omized comparison of coronary stent implantation under ultrasound or angiographic guidance to reduce stent restenosis(OPTICUS Study)显示文摘 | MUDRA H D I MARIO C D E JAEGERE P | 2001 | Circulation2001，104，： | 1 |
| 15 | Randomized comparison of coronary stent implantation under ultrasound or angiographic guidance to reduce stent restenosis(OPTICUS study)显示文摘 | MUDRA H DI MARIO C DE JAEGERE P | 2001 | Circulation2001，104，： | 1 |
| 16 | Effect of prepa- ration procedure of IrOz-Nb2 O5 anodes on surface and electrocatalytic properties显示文摘 | Mario H P Santana Luiz A | 2005 | J Appl Electrochem2005，35，： | 1 |
| 17 | Prenatal development of the alpaca(Lama pacos) 显示文摘 | Brav P W and Mario H Varela | 1993 | Anim Reproduc Sci1993，32，： | 1 |
| 18 | Oxygen and chlorine evolution on RuO2 + TiO2+ CeO2 + Nb2O5 mixed oxide electrodes 显示文摘 | Mario H P Santana Luiz A De Faria | 2006 | Electrochim Acta2006，51，17： | 1 |
| 19 | Microsurgery can cure most intracraniai dural arteriovenous fistulae of the sinus and non-sinus type显示文摘 | Dorothee W Franz H Marios N P | 2011 | Neurosurgical Review2011，34，3： | 1 |
| 20 | How Organizational Culture Influences Outcome Information Utilization 显示文摘 | Sharon P H Mario H | 1999 | Evaluation and Program Planning1999，22，2： | 1 |
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