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| 1 | Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer显示文摘BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive factors.AIM To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC patients.METHODS This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese hospitals.Means were compared through non-parametric Mann-Whitney tests.Receiver operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent variable.RESULTS This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of death.CONCLUSION Higher NLR is correlated with longer survival time.High LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT and dying.Patients with TSR and a pathological response have better OS and lower risk of dying. | Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza | 2022 | World Journal of Gastrointestinal Oncology2022，14，7： | 2 |
| 2 | Safety of Performing a Delayed Anastomosis During Damage Control Laparotomy in Patients With Destructive Colon Injuries显示文摘 | Carlos A. Ordo?ez Luis F. Pino Marisol Badiel Alvaro I. Sánchez Jhon Loaiza Leonardo Ballestas Juan Carlos Puyana | 2011 | The Journal of Trauma: Injury Infection and Critical Care2011，，6： | 1 |
| 3 | Mycelium development in Streptomyces antibioticus ATCClI891 occurs in an orderly pattern which determines multiphase growth curves 显示文摘 | Angel M Marisol F Jesus S | 2005 | BMC Microbiology2005，5，51： | 1 |
| 4 | A death round affecting a young compartmentalized myeeliurn precedes aerial mycelium dismantling in confluent surface cultures of Streptomyces antibiotlcus 显示文摘 | Angel M Marisol F Jesus S | 2005 | Microbiology2005，151，1： | 1 |
| 5 | The end-effectors of preconditioning protection against myocardial celldeath secondary to ischemic-reperfu-sion显示文摘 | David G D Antonio R S Marisol R M | 2006 | CardiovascuLar Research2006，70，1： | 1 |
| 6 | Characterising Mycobacterium tuberculosis Rv1510c protein and determining its sequences that specifically bind to two target cell lines显示文摘 | Ricardo Vera-Bravo Elizabeth Torres John J. Valbuena Marisol Ocampo Luis E. Rodríguez álvaro Puentes Javier E. García Hernando Curtidor Jimena Cortés Magnolia Vanegas Zuly J. Rivera Andrea Díaz Martha N. Calderon Manuel A. Patarroyo Manuel E. Patarroyo | 2005 | Biochemical and Biophysical Research Communications2005，，： | 1 |
| 7 | Electrodeposition of ordered Bi2Te3 nanowire arrays显示文摘 | Amy L P Melissa S S Marisol S | 2001 | J Am Chem Soc2001，123，29： | 1 |
| 8 | Improving ITS sequence data for identification of plant pathogenic fungi显示文摘Plant pathogenic fungi are a large and diverse assemblage of eukaryotes with substantial impacts on natural ecosystems and human endeavours.These taxa often have complex and poorly understood life cycles,lack observable,discriminatory morphological characters,and may not be amenable to in vitro culturing.As a result,species identification is frequently difficult.Molecular(DNA sequence)data have emerged as crucial information for the taxonomic identification of plant pathogenic fungi,with the nuclear ribosomal internal transcribed spacer(ITS)region being the most popular marker.However,international nucleotide sequence databases are accumulating numerous sequences of compromised or low-resolution taxonomic annotations and substandard technical quality,making their use in the molecular identification of plant pathogenic fungi problematic.Here we report on a concerted effort to identify high-quality reference sequences for various plant pathogenic fungi and to re-annotate incorrectly or insufficiently annotated public ITS sequences from these fungal lineages.A third objective was to enrich the sequences with geographical and ecological metadata.The results-a total of 31,954 changes-are incorporated in and made available through the UNITE database for molecular identification of fungi(http://unite.ut.ee),including standalone FASTA files of sequence data for local BLAST searches,use in the next-generation sequencing analysis platforms QIIME and mothur,and related applications.The present initiative is just a beginning to cover the wide spectrum of plant pathogenic fungi,and we invite all researchers with pertinent expertise to join the annotation effort. | R.Henrik Nilsson Kevin D.Hyde Julia Pawlowska Martin Ryberg Leho Tedersoo Anders Bjornsgard Aas Siti A.Alias Artur Alves Cajsa Lisa Anderson Alexandre Antonelli A.Elizabeth Arnold Barbara Bahnmann Mohammad Bahram Johan Bengtsson-Palme Anna Berlin Sara Branco Putarak Chomnunti Asha Dissanayake Rein Drenkhan Hanna Friberg Tobias Guldberg Froslev Bettina Halwachs Martin Hartmann Beatrice Henricot Ruvishika Jayawardena Ari Jumpponen Havard Kauserud Sonja Koskela Tomasz Kulik Kare Liimatainen Bjorn D.Lindahl Daniel Lindner Jian-Kui Liu Sajeewa Maharachchikumbura Dimuthu Manamgoda Svante Martinsson Maria Alice Neves Tuula Niskanen Stephan Nylinder Olinto Liparini Pereira Danilo Batista Pinho Teresita M.Porter Valentin Queloz Taavi Riit Marisol Sánchez-García Filipe de Sousa Emil Stefańczyk Mariusz Tadych Susumu Takamatsu Qing Tian Dhanushka Udayanga Martin Unterseher Zheng Wang Saowanee Wikee Jiye Yan Ellen Larsson Karl-Henrik Larsson Urmas Koljalg Kessy Abarenkov | 2014 | Fungal Diversity2014，，4： | 1 |
| 9 | Relative Acculturation Extended Model (RAEM): New contributions with regard to the study of acculturation显示文摘 | Marisol Navas María C. García Juan Sánchez Antonio J. Rojas Pablo Pumares Juan S. Fernández | 2005 | International Journal of Intercultural Relations2005，，1： | 1 |
| 10 | Natural triterpenoids from Cecropia lyratiloba are cytotoxic to both sensitive and multidrug resistant leukemia cell lines显示文摘 | Gleice G R Marisol S Kelly A L | 2007 | Bioorg Med Chem2007，15，23： | 1 |
| 11 | C‐reactive protein and incidence of type 2 diabetes in the Pizarra study显示文摘 | Elehazara Rubio‐Martín Federico Soriguer Carolina Gutiérrez‐Repiso Lourdes Garrido‐Sánchez Marisol S. Ruíz Adana Eduardo García‐Fuentes Sonsoles Morcillo Isabel Esteva Felipe J Chaves Gemma Rojo‐Martinez | 2012 | Eur J Clin Invest2012，，2： | 1 |
| 12 | Connexin and pannexin as modulators of myocardial injury显示文摘 | Antonio Rodríguez-Sinovas Jose A. Sánchez Celia Fernandez-Sanz Marisol Ruiz-Meana David Garcia-Dorado | 2011 | BBA - Biomembranes2011，，8： | 1 |
| 13 | Seroprevalence of viral and bacterial pathogens among malaria patients in an endemic area of southern Venezuela显示文摘Background Malaria remains a leading public health problem worldwide.Co-infections with other pathogens complicate its diagnosis and may modify the disease’s clinical course and management.Similarities in malaria clinical presentation with other infections and overlapping endemicity result in underdiagnosis of co-infections and increased mortality.Thus,the aim of this study was to determine the seroprevalence of viral and bacterial pathogens among diagnosed malaria patients in malaria-endemic areas in Venezuela.Methods A cross-sectional study was conducted on malaria patients attending three reference medical centres in Ciudad Bolivar,Venezuela.Clinical evaluation and laboratory tests for dengue virus(DENV),chikungunya virus(CHIKV),viral hepatitis[hepatitis A virus(HAV),hepatitis B virus(HBV),and hepatitis C virus(HCV)],and leptospirosis(LEP)were performed by enzyme-linked immunosorbent assays.Previous exposure to these pathogens was defined by the presence of specific immunoglobulin(Ig)G,and co-infection or recent exposure(CoRE)was determined by the presence of specific IgM alone or IgM+IgG.Data analysis considered descriptive statistics.Parameter distribution was statistically evaluated using Kolmogorov–Smirnov test and the necessary comparison tests.Odds ratio(OR)for complications was determined according to CoRE presence with a 95%confidence interval(CI).Results A total of 161 malaria patients were studied,66%infected with Plasmodium vivax,27%with P.falciparum,and 7.5%harboured P.vivax/P.falciparum mixed infection.Previous exposure to DENV(60%)and CHIKV(25%)was frequent.CoRE was confirmed in 55 of the 161 malaria patients(34%)and were more frequent in P.falciparum(49%)than in P.vivax(29%)and mixed malaria patients(25%)(OR=2.43,95%CI:1.39–4.25,P=0.018).The most frequent CoRE was DENV(15%),followed by HAV(12%),HBV(6.2%),CHIKV(5.5%),and LEP(3.7%);HCV CoRE was absent.Complicated malaria was significantly more frequent in patients with CoRE(56%)than those without CoRE(36%;OR=2.31,95%CI:1.18–4.92,P=0.013).Conclusions We found high CoRE prevalence in malaria patients as determined by serology in the study region;cases were associated with a worse clinical outcome.Further prospective studies with samples from different infection sites and the use of molecular tools are needed to determine the clinical significance of these findings. | David A.Forero-Peña Fhabián S.Carrión-Nessi Mary Lopez-Perez Marisol Sandoval-de Mora Iván D.Amaya Ángel F.Gamardo Melynar Chavero Luisamy Figuera María V.Marcano Natasha A.Camejo-Ávila Mariana Hidalgo Cariagne J.Arenas Myriam Arévalo-Herrera Sócrates Herrera | 2023 | Infectious Diseases of Poverty2023，12，2： | 0 |
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