|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Elucidation of the life cycle of the endophytic genus Muscodor and its transfer to Induratia in Induratiaceae fam. nov., based on a polyphasic taxonomic approach显示文摘Molecular phylogenetic studies of cultures derived from some specimens of plant-inhabiting Sordariomycetes using ITS,LSU,rpb2 and tub2 DNA sequence data revealed close affinities to strains of Muscodor.The taxonomy of this biotechnologi-cally important genus,which exclusively consists of endophytes with sterile mycelia that produce antibiotic volatile secondary metabolites,was based on a rather tentative taxonomic concept.Even though it was accommodated in Xylariaceae,its phylo-genetic position had so far remained obscure.Our phylogeny shows that Muscodor species have affinities to the xylarialean genera Emarcea and Induratia,which is corroborated by the fact that their sexual states produce characteristic apiospores.These data allow for the integration of Muscodor in Induratia,i.e.the genus that was historically described first.The multi-locus phylogenetic tree clearly revealed that a clade comprising Emarcea and Induratia forms a monophylum separate from representatives of Xylariaceae,for which we propose the new family Induratiaceae.Divergence time estimations revealed that Induratiaceae has been diverged from the Xylariaceae+Clypeosphaeriaceae clade at 93(69-119)million years ago(Mya)with the crown age of 61(39-85)Mya during the Cretaceous period.The ascospore-derived cultures were studied for the production of volatile metabolites,using both,dual cultures for assessment of antimicrobial effects and extensive analyses using gas chromatography coupled with mass spectrometry(GC-MS).The antimicrobial effects observed were significant,but not as strong as in the case of the previous reports on Muscodor species.The GC-MS results give rise to some doubt on the validity of the previous identification of certain volatiles.Many peaks in the GC-MS chromatograms could not be safely identified by database searches and may represent new natural products.The isolation of these compounds by preparative chromatography and their subsequent characterisation by nuclear magnetic resonance(NMR)spectroscopy or total synthesis will allow for a more concise identification of these volatiles,and they should also be checked for their individual contri-bution to the observed antibiotic effects.This will be an important prerequisite for the development of biocontrol strains. | Milan C.Samarakoon Benjarong Thongbai Kevin D.Hyde Mark Brönstrup Ulrike Beutling Christopher Lambert Andrew N.Miller Jian‑Kui(Jack)Liu Itthayakorn Promputtha Marc Stadler | 2020 | Fungal Diversity2020，，2： | 2 |
| 2 | The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease显示文摘 | ? ystein Brenna Torunn Bruland Marianne W. Furnes Atle van Beelen Granlund Ignat Drozdov Johanna Emg? rd Gunnar Br? nstad Mark Kidd Arne K. Sandvik Bj? rn I. Gustafsson | 2015 | Scandinavian Journal of Gastroenterology2015，，10： | 1 |
| 3 | Presentation and outcome of hepatocellular carcinoma in HIV-infected patients: A U.S.–Canadian multicenter study显示文摘 | Norbert Br?u Rena K. Fox Peiying Xiao Kristen Marks Zeenat Naqvi Lynn E. Taylor Anita Trikha Morris Sherman Mark S. Sulkowski Douglas T. Dieterich Michael O. Rigsby Teresa L. Wright Maria D. Hernandez Mamta K. Jain Gajendra K. Khatri Richard K. Sterling M | 2007 | Journal of Hepatology2007，，4： | 1 |
| 4 | In vivo and In vitro Characterization of insulin-producing cells obtained from murine bone marrow显示文摘 | Sally A Mark A Burkardt BR | 2004 | Diabets2004，53，： | 1 |
| 5 | ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity显示文摘 | Odegard JM Marks BR DiPlacido LD | 2008 | J Exp Med2008，205，： | 1 |
| 6 | Thymic self- reactivity selects natural interleukin 17-produeing T cells that can regulate peripheral inflammation 显示文摘 | Marks BR Nowyhed HN Choi JY | 2009 | Nat Immunol2009，10，10： | 1 |
| 7 | Role of transforming growth factor-β signaling in cancer显示文摘 | Mark P Caestecker EP Anita BR | 2000 | Journal of the National Cancer InstituteVol2000，92，17： | 1 |
| 8 | ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity显示文摘 | Odegard JM Marks BR DiPlacido LD | 2008 | J Exp Med2008，12，： | 1 |
| 9 | Barrier immunity and IL-17 显示文摘 | Marks BR Craft J | 2009 | Semin Immunol2009，21，3： | 1 |
| 10 | Anorectal Malignant Melanoma: Extensive 45-Year Review and Proposal for a Novel Staging Classification显示文摘 | Claudius Falch Alexander Stojadinovic Claus Hann-von-Weyhern Mladjan Protic Aviram Nissan Mark B. Faries Martin Daumer Anton J. Bilchik Avital Itzhak Bj?rn L.D.M. Brücher | 2013 | Journal of the American College of Surgeons2013，，2： | 1 |
| 11 | Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes显示文摘 | Rohit N Kulkarni Jens C Brüning Jonathon N Winnay Catherine Postic Mark A Magnuson C.Ronald Kahn | 1999 | Cell1999，，3： | 1 |
| 12 | Barrier immunity and IL-17显示文摘 | Marks BR Craft J | 2009 | Semin Immunol2009，21，： | 1 |
| 13 | ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity显示文摘 | Odegard JM Marks BR DiPlacido LD | | 0，，12： | 1 |
| 14 | H2S induces a suspended animation-like state in miee 显示文摘 | Eric B Mike M Mark BR | 2005 | Science2005，308，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员