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| 1 | Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China. | Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 2 |
| 2 | Cerebral Microbleeds in the Elderly: A Pathological Analysis显示文摘 | Mark Fisher Samuel French Ping Ji Ronald C. Kim | 2010 | Stroke2010，，12： | 2 |
| 3 | 用于脂肪移植及脂肪干细胞分离获取与处理技术的对比显示文摘背景与目的脂肪获取和处理技术的差异可能会影响脂肪移植的成功率。本研究利用裸鼠模型,对比不同处理方法获取的脂肪移植物的性质,并评估移植脂肪组织中存活组织的体积。方法第一阶段,通过负压吸引辅助脂肪抽吸或超声辅助脂肪抽吸2种方式获取脂肪,并利用2种孔隙尺寸的筛网进行过滤。对移植材料的如下方面进行分析:平均团块大小,油脂、脂肪和水溶性成分的构成比,以及基质血管细胞群(stromalvascularfraction,SVF)的产量。将过滤物及滤液注入无胸腺的裸鼠皮下。第二阶段,将仅通过负压吸引吸脂术中获取脂肪抽吸物,进行离心、纱布摇匀或过滤处理,然后利用相似的规范进行研究。结果与负压吸引脂肪抽吸术相比,超声辅助的脂肪抽吸术获取的脂肪在SVF含量和脂肪移植体内研究成活量情况均相似。通过超声辅助的脂肪抽吸术仅比负压脂肪抽吸术产生稍微多的油脂;通过500μm或800μm孔径的滤网进行过滤均可有效去除液体和油脂。利用纱布法处理的脂肪,其体内移植成活率和SVF产量均最高。对所有移植物的组织学分析均显示为完整的脂肪组织。结论通过超声辅助及负压吸引行脂肪抽吸术获取的脂肪,其在异种移植模型中具有相似的成活率。对于少量填充移植而要求最佳成活率的身体敏感区域而言,利用纱布摇匀的处理方式可能是用于美容性脂肪移植的最佳方法。过滤法和离心法均可有效去除液体成分,其处理过的脂肪具有相似的移植成活率,当所需移植体积较大时,这2种方法均可行。 | Christine Fisher Tara L. Grahovac Mark E. Schafer Ron D. Shippert Kacey G. Marra J. Peter Rubin 魏峰 高景恒 张晨 | 2014 | 中国美容整形外科杂志2014，25，4： | 2 |
| 4 | Carotid Plaque Pathology: Thrombosis, Ulceration, and Stroke Pathogenesis显示文摘 | Mark Fisher Annlia Paganini-Hill Aldana Martin Michele Cosgrove James F. Toole Henry J.M. Barnett John Norris | 2005 | Stroke2005，，2： | 2 |
| 5 | Molecular cloning and characterization of the Amylose-Extender gene encoding starch branching enzyme IIB in maize显示文摘 | Kyung-Nam Kim Dane K. Fisher Ming Gao Mark J. Guiltinan | 1998 | Plant Molecular Biology1998，，6： | 1 |
| 6 | Long-run Neutrality and Super Neutrality in an ARIMA Frame- work显示文摘 | Fisher Mark E and John J Seater | 1993 | American Economic Review1993，，83： | 1 |
| 7 | Evolutionary conservation and expression patterns of maize starch branching enzyme I and IIb genes suggests isoform specialization显示文摘 | Ming Gao Dane K. Fisher Kyung-Nam Kim Jack C. Shannon Mark J. Guiltinan | 1996 | Plant Molecular Biology1996，，6： | 1 |
| 8 | An adaptive algorithm for image restoration using combined penalty functions显示文摘 | Razaz Moe Fisher Mark | 2006 | Pattern Recognition Letters2006，27，12： | 1 |
| 9 | A passivewireless multi-sensor SAW technology device and system per-spectives 显示文摘 | Malocha Donald C Gallagher Mark Fisher Brian | 2013 | Sensors2013，13，5： | 1 |
| 10 | Leadership Education for Young Adult Librarians:A Research Study 显示文摘 | Winston Mark D Fisher Deborah | 2003 | Public Library Quarterly2003，22，03： | 1 |
| 11 | Phase I Trial of Intravesical Recombinant Adenovirus Mediated Interferon-α2b Formulated in Syn3 for Bacillus Calmette-Guérin Failures in Nonmuscle Invasive Bladder Cancer显示文摘 | Colin P.N. Dinney Mark B. Fisher Neema Navai Michael A. O’Donnell David Cutler Alice Abraham Sophia Young Beth Hutchins Maria Caceres Narendra Kishnani George Sode Constance Cullen Guangcheng Zhang H. Barton Grossman Ashish M. Kamat Marshall Gonzales Mich | 2013 | The Journal of Urology2013，，： | 1 |
| 12 | Perforated appendicitis: Is early laparoscopic appendectomy appropriate?显示文摘 | Rami Sleem Sabrina Fisher Mark Gestring Julius Cheng Ayodele Sangosanya Nicole Stassen Paul Bankey | 2009 | Surgery2009，，4： | 1 |
| 13 | The interdependence of mechanisms underlying climate-driven vegetation mortality显示文摘 | Nate G. McDowell David J. Beerling David D. Breshears Rosie A. Fisher Kenneth F. Raffa Mark Stitt | 2011 | Trends in Ecology & Evolution2011，，10： | 1 |
| 14 | Preoperative chemoradiation for marginally resectable adenocarcinoma of the pancreas显示文摘 | Vivek K. Mehta M.D. George Fisher M.D. Ph.D. James A. Ford M.D. Joseph C. Poen M.D. Mark A. Vierra M.D. Harry Oberhelman M.D. John Niederbuber M.D. Augusto Bastidas M.D | 2001 | Journal of Gastrointestinal Surgery2001，，1： | 1 |
| 15 | A Passive Wireless Multi-Sensor SAW Technology Device and System Per- spectives 显示文摘 | Donald C Malocha Mark Gallagher Brian Fisher | 2013 | Sensors2013，13，5： | 1 |
| 16 | Cerebral Microbleeds in the Elderly:A Pathological Analysis显示文摘 | Mark Fisher MD Samuel French MD Ping Ji MD | | 0，，： | 1 |
| 17 | Synthesis and characterization of an isocyanate functionalized polyhe- dral oligosilsesquioxane and the subsequent formation of an organic inorganic hybrid polyurethane显示文摘 | Daniel Neumann Mark Fisher Linh Tran | 2002 | J Am Chem Soc2002，124，13： | 1 |
| 18 | Long - Run Neutrality and Supemeutrality in an ARIMA Framework 显示文摘 | Fisher Mark and John Seater | 1993 | American Economic Review1993，，83： | 1 |
| 19 | Prophylactic neck irradiated in patients with squanous cell carcinom 7a of the maxillary sinus显示文摘 | Fisher SG Marks JE | 1995 | Int Radiar Oncol Biol Phys1995，321，2： | 1 |
| 20 | Pericyte Signaling in the Neurovascular Unit显示文摘 | Mark Fisher | 2009 | 2009 (3 Su)2009，，3： | 1 |
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