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| 1 | Advanced smart biomaterials and constructs for hard tissue engineering and regeneration显示文摘Hard tissue repair and regeneration cost hundreds of billions of dollars annually worldwide, and the need has substantially increased as the population has aged. Hard tissues include bone and tooth structures that contain calcium phosphate minerals.Smart biomaterial-based tissue engineering and regenerative medicine methods have the exciting potential to meet this urgent need. Smart biomaterials and constructs refer to biomaterials and constructs that possess instructive/inductive or triggering/stimulating effects on cells and tissues by engineering the material's responsiveness to internal or external stimuli or have intelligently tailored properties and functions that can promote tissue repair and regeneration. The smart material-based approaches include smart scaffolds and stem cell constructs for bone tissue engineering; smart drug delivery systems to enhance bone regeneration; smart dental resins that respond to pH to protect tooth structures; smart pH-sensitive dental materials to selectively inhibit acid-producing bacteria; smart polymers to modulate biofilm species away from a pathogenic composition and shift towards a healthy composition; and smart materials to suppress biofilms and avoid drug resistance. These smart biomaterials can not only deliver and guide stem cells to improve tissue regeneration and deliver drugs and bioactive agents with spatially and temporarily controlled releases but can also modulate/suppress biofilms and combat infections in wound sites. The new generation of smart biomaterials provides exciting potential and is a promising opportunity to substantially enhance hard tissue engineering and regenerative medicine efficacy. | Ke Zhang Suping Wang Chenchen Zhou Lei Cheng Xianling Gao Xianju Xie Jirun Sun Haohao Wang Michael D.Weir Mark A.Reynolds Ning Zhang Yuxing Bai Hockin H.K.Xu | 2018 | Bone Research2018，6，4： | 6 |
| 2 | Effects of water-aging for 6 months on the durability of a novel antimicrobial and protein-repellent dental bonding agent显示文摘Biofilms at the tooth-restoration bonded interface can produce acids and cause recurrent caries. Recurrent caries is a primary reason for restoration failures. The objectives of this study were to synthesize a novel bioactive dental bonding agent containing dimethylaminohexadecyl methacrylate(DMAHDM) and 2-methacryloyloxyethyl phosphorylcholine(MPC) to inhibit biofilm formation at the tooth-restoration margin and to investigate the effects of water-aging for 6 months on the dentin bond strength and protein-repellent and antibacterial durability. A protein-repellent agent(MPC) and antibacterial agent(DMAHDM) were added to a Scotchbond multi-purpose(SBMP) primer and adhesive. Specimens were stored in water at 37 °C for 1, 30, 90, or 180 days(d).At the end of each time period, the dentin bond strength and protein-repellent and antibacterial properties were evaluated. Protein attachment onto resin specimens was measured by the micro-bicinchoninic acid approach. A dental plaque microcosm biofilm model was used to test the biofilm response. The SBMP + MPC + DMAHDM group showed no decline in dentin bond strength after water-aging for 6 months, which was significantly higher than that of the control(P < 0.05). The SBMP + MPC + DMAHDM group had protein adhesion that was only 1/20 of that of the SBMP control(P < 0.05). Incorporation of MPC and DMAHDM into SBMP provided a synergistic effect on biofilm reduction. The antibacterial effect and resistance to protein adsorption exhibited no decrease from 1 to 180 d(P > 0.1). In conclusion, a bonding agent with MPC and DMAHDM achieved a durable dentin bond strength and long-term resistance to proteins and oral bacteria. The novel dental bonding agent is promising for applications in preventive and restorative dentistry to reduce biofilm formation at the tooth-restoration margin. | Ning Zhang Ke Zhang Michael D.Weir David J.Xu Mark A.Reynolds Yuxing Bai Hockin H.K.Xu | 2018 | International Journal of Oral Science2018，10，3： | 4 |
| 3 | Utility of left subclavian artery revascularization in association with endoluminal repair of acute and chronic thoracic aortic pathology显示文摘 | Brain GP Mark KE Thomas GG | 2006 | J Vase Surg2006，43，： | 1 |
| 4 | Different definitions in childhood asthma:how dependable is the dependent variable? 显示文摘 | Van Wonderen KE Van Der Mark LB Mohrs J | 2010 | Eur Respir J2010，36，1： | 1 |
| 5 | Folate-receptor-targeted radionuclide imaging agents显示文摘 | Chun-Yen Ke Carla J Mathias Mark A Green | 2004 | Advanced Drug Delivery Reviews2004，，8： | 1 |
| 6 | Prediction and treatment of asthma in preschool children at risk: study design and baseline data of a prospective cohort study in general practice (ARCADE) 显示文摘 | van Wonderen KE van der Mark LB Mohrs J et d | 2009 | BMC Pulm Med2009，9，： | 1 |
| 7 | Targeted prenatal herpes simplex virus testing:can we identify women at risk of transmission to the neonate? 显示文摘 | Mark KE Kim HN Wald A | 2006 | Am J Obstet Gynecol2006，194，2： | 1 |
| 8 | Rapidly cleared episodes of oral and anogenital herpes simplex virus shedding in HIV-infected adults显示文摘 | Mark KE Wald A Magaret AS | 2010 | J Acquir Immune Defic Syndr2010，54，5： | 1 |
| 9 | Vancomycin vs tobramycin elution from polymethyimethacrylate: an in vitro study显示文摘 | Lawson KJ Marks KE Brems J Rehm S | 1990 | Orthopedics1990，13，3： | 1 |
| 10 | Papillary clear cell adenocarcinoma of the groin arising from endometriosis显示文摘 | Klein AE Bauer TW Marks KE | 1999 | Clin Orthop Relat Res1999，361，2： | 1 |
| 11 | Survival Outcomes in Resected Extrahepatic Cholangiocarcinoma: Effect of Adjuvant Radiotherapy in a Surveillance, Epidemiology, and End Results Analysis显示文摘 | Tamara Z. Vern-Gross Anand T. Shivnani Ke Chen Christopher M. Lee Jonathan D. Tward O. Kenneth MacDonald Christopher H. Crane Mark S. Talamonti Louis L. Munoz William Small | 2011 | International Journal of Radiation Oncology Biology Physics2011，，1： | 1 |
| 12 | Mesial tempoual sclerosis and temporal lobe epilepsy: MR imaging deformation-based segmention of the hippocampus in five patients显示文摘 | Hogan RE Mark KE Wang Lei | 2000 | Radiology2000，216，： | 1 |
| 13 | Frequent release of low amounts of herpes simplex virus from neurons:results of a mathematical model显示文摘 | Schiffer JT AbuRaddad L Mark KE | 2009 | Science Translational Medicine2009，1，7： | 1 |
| 14 | Mechanical strength of acrylic bone cements impregnated with antibiotics 显示文摘 | Lantensehlagor EP Marshall GW Marks KE | 1976 | J Biomed Mater Res1976，6，： | 1 |
| 15 | HIV mother-to-child transmission,mode of delivery,and duration of rupture of membranes:experience in the current era显示文摘 | Mark S Murphy KE Read S | | 0，，： | 1 |
| 16 | Mechanical strength of acrylic bone cements impregnated with antibiotics显示文摘 | Lautenschlager EP Marshall GW Marks KE | 1976 | J Biomed Mater Res1976，10，： | 1 |
| 17 | Antibioticimpregnated acrylic bone cement显示文摘 | Marks KE Nelson CL Lautenschlager EP | 1976 | J Bone Joint Surg1976，58，： | 1 |
| 18 | Mesial temporal sclerosis and temporal lobe epilepsy:MR imaging deformation -based segmentation of the hippocampus in five patients显示文摘 | Hogan RE Mark KE Wang Lei | 2000 | Radiology2000，216，1： | 1 |
| 19 | Vancomycinvs tobramycin elu- tion from polymethylmethacrylate: an in vitro study 显示文摘 | Lawson KJ Marks KE Brews J | 1990 | Orthopedics1990，5，： | 1 |
| 20 | Expression of vascular endothelial growth factor and proliferation marker MIB1 are influenced by neoadjuvant chemotherapy in locally advanced breast cancer显示文摘 | Singh M Capocelli KE Marks JL | | 0，，02： | 1 |
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