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| 1 | 159例腹腔镜根治性前列腺癌切除术的疗效评估显示文摘目的探讨腹腔镜根治性前列腺切除术的疗效.方法回顾性分析2000年3月至2003年8月159例腹腔镜根治性前列腺切除术患者资料.平均年龄58岁(42~74岁),同时行双侧盆腔淋巴结清扫术57例(35.9%).术前159例患者前列腺活检均确诊为前列腺癌.Gleason肿瘤分级:3+3:129例(81.1%),3+4:23例(14.5%),4+3:4例(2.5%),4+4:3例(1.9%).TNM肿瘤分期:T1c126例(79.3%),T2a 33例(20.7%).结果 159例患者平均手术时间298 min(165~660min).术中估计失血量平均293 ml(50~2500 ml),发生严重并发症15例(9.4%),其中中转开放手术6例(3.8%),无死亡病例.术后病理确诊为前列腺癌158例,1例诊断为良性前列腺增生伴急性前列腺炎.标本切缘阳性34例(21.5%).术后1年53例患者获得随访,术前31例(58.5%)有阴茎勃起功能的患者根据国际阴茎勃起功能指数(ⅡEF-5)评分分组进行术后变化评估.术后ⅡEF-5评分显著下降,各评分组间的差异无统计学意义.36例(67.9%)可通过使用Viagra等药物进行性生活,6例(11.3%)有尿失禁.结论腹腔镜根治性前列腺切除术是一种相对安全、微创、并发症低、术后康复快,同时又能达到肿瘤治疗效果的手术方法.但长期疗效尚待进一步观察. | 李爱华 Demetrius H.Bagley Edouard Trabulsi Deborah T.Glassman Stephen Strup Mark Chang Dolores Shupp-Byrne Leonard G.Gomella | 2005 | 中华泌尿外科杂志2005，26，12： | 4 |
| 2 | Advances in radiotherapy and targeted therapies for rectal cancer显示文摘The last decade witnessed a significant progress in understanding the biology and immunology of colorectal cancer alongside with the technical innovations in radiotherapy.The stepwise implementation of intensitymodulated and image-guided radiation therapy by means of megavolt computed tomography and helical tomotherapy enabled us to anatomically sculpt dose delivery,reducing treatment related toxicity.In addition,the administration of a simultaneous integrated boost offers excellent local control rates.The novel challenge is the development of treatment strategies for medically inoperable patient and organ preserving approaches.However,distant control remains unsatisfactory and indicates an urgent need for biomarkers that predict the risk of tumor spread.The expected benefit of target?ed therapies that exploit the tumor genome alone is so far hindered by high cost techniques and pharmaceuticals,hence hardly justifying rather modest improvements in patient outcomes.On the other hand,the immune landscape of colorectal cancer is now better clarified with regard to the immunosuppressive network that promotes immune escape.Both N2 neutrophils and myeloid-derived suppressor cells(MDSC)emerge as useful clinical biomarkers of poor prognosis,while the growing list of anti-MDSC agents shows promising ability to boost antitumor T-cell immunity in preclinical settings.Therefore,integration of genetic and immune biomarkers is the next logical step towards effective targeted therapies in the context of personalized cancer treatment. | Alexandra Sermeus Wim Leonard Benedikt Engels Mark De Ridder | 2014 | World Journal of Gastroenterology2014，20，1： | 3 |
| 3 | Targeted prostate biopsy: value of multiparametric magnetic resonance imaging in detection of localized cancer显示文摘前列腺癌症是在人的第二很普通的癌症,与一最近的年里的世界健康组织全球报导的 110 万个新案例。指导活体检视被用于的 Transrectal 超声(TRUS ) 为超过 2 十年的前列腺癌症的诊断,而是这种技术对癌症通常盲目地点。而且, TRUS 活体检视的假否定的率被报导了象 47% 一样高。Multiparametric 磁性的回声成像(mp-MRI ) 包括 T1 加权、 T2 加权的成像象一样动态提高对比(数据通信设备) 并且散开加权的成像(DWI ) 。mp-MRI 是在前列腺癌症的成像的主要进展,启用可疑损害的指向的活体检视。演变指向的活体检视 techniques—包括的直接在里面厌烦活体检视,认知熔化和基于软件的 MRI 超声(MRI 美国) fusion—与更早的方法相比在癌症察觉导致了好几倍的改进。重要地,临床上重要的癌症的察觉被指向极大地便于,与系统的活体检视相比独自一个。经由 MRI 美国熔化的指向的活体检视可以戏剧性地改变前列腺癌症被诊断并且设法的方法。 | Jesse D Le Jiaoti Huang Leonard S Marks | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 4 | Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration显示文摘 | Wolfram Goessling Trista E. North Sabine Loewer Allegra M. Lord Sang Lee Cristi L. Stoick-Cooper Gilbert Weidinger Mark Puder George Q. Daley Randall T. Moon Leonard I. Zon | 2009 | Cell2009，，6： | 2 |
| 5 | 手助式腹腔镜肾切除术围手术期并发症的处理显示文摘目的探讨手助式腹腔镜肾切除术围手术期并发症的处理方法。方法回顾性分析1998-2004年377例手助式腹腔镜肾切除术患者资料,其中根治性肾切除术206例,单纯性肾切除术91例,根治性肾、输尿管切除术49例,肾部分切除术31例,对围手术期并发症类型、发生率及处理方法进行统计分析。结果377例患者术中估计失血量平均315.6 ml(30~7000 m1)。术中发生脾脏损伤、难以控制的出血、肠道损伤、肾蒂血管损伤、胰腺损伤等并发症14例(3.7%)。中转开放手术13例(3.4%)。术后发生肠梗阻、肺炎、切口疝、继发性出血、冠心病发作、血管栓塞、低钠血症等并发症48例(12.7%)。死亡2例(0.5%)。有腹腔或腹膜后手术史者围手术期并发症和术式中转率高于无手术史者。结论手助式腹腔镜。肾切除术仍会出现一些严重的围手术期并发症。局部粘连、肿瘤体积过大会增加并发症的发生。术中一旦出现严重出血、器官损伤等难以控制的并发症时应及时中转开放手术。充分的术前准备、正确熟练的手术操作可降低并发症的发生率。 | 李爱华 Leonard G.Gomella Ramsay Kuo Dolores Shupp-Byrne Mark Chang Stephen Strup Demetrias H.Bagley | 2006 | 中华泌尿外科杂志2006，27，10： | 2 |
| 6 | Guidelines for the prevention of intravascular catheter-related infections显示文摘 | Naomi P. O’Grady Mary Alexander Lillian A. Burns E. Patchen Dellinger Jeffrey Garland Stephen O. Heard Pamela A. Lipsett Henry Masur Leonard A. Mermel Michele L. Pearson Issam I. Raad Adrienne G. Randolph Mark E. Rupp Sanjay Saint | 2011 | AJIC: American Journal of Infection Control2011，，4： | 2 |
| 7 | Axon regeneration through scars and into sites of chronic spinal cord injury显示文摘 | Paul Lu Leonard L. Jones Mark H. Tuszynski | 2006 | Experimental Neurology2006，，1： | 2 |
| 8 | Breast Conservation Therapy: The Influence of Molecular Subtype and Margins显示文摘 | Senem Demirci Gloria Broadwater Lawrence B. Marks Robert Clough Leonard R. Prosnitz | 2012 | International Journal of Radiation Oncology Biology Physics2012，，3： | 1 |
| 9 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 10 | Efficacy and safety of dutasteride in the four-year treatment of men with benign prostatic hyperplasia显示文摘 | Roehrborn Claus G Marks Leonard S Fenter Tom | 2004 | Urology2004，63，4： | 1 |
| 11 | A comment on recent teaching of human anatomy in the United States显示文摘 | Cahill D R Leonard R J Marks Jr S C | 2000 | Surg Radiol Anat2000，22，： | 1 |
| 12 | Barrett’s esophagus: cancer and molecular biology显示文摘 | Michael K. Gibson Arashinder S. Dhaliwal Nicholas J. Clemons Wayne A. Phillips Katerina Dvorak Daniel Tong Simon Law E. Daniel Pirchi Jari R?s?nen Mark J. Krasna Kaushal Parikh Kausilia K. Krishnadath Yu Chen Leonard Griffiths Benjamin J. Colleypriest J. | 2013 | Ann NY Acad Sci2013，，1： | 1 |
| 13 | Relation between pO 2 , 31 P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy显示文摘 | Mark W. Dewhirst Jean M. Poulson Daohai Yu Linda Sanders Micha?l Lora-Michiels Zeljko Vujaskovic Ellen L. Jones Thaddeus V. Samulski Barbara E. Powers David M. Brizel Leonard R. Prosnitz H. Cecil Charles | 2005 | International Journal of Radiation Oncology Biology Physics2005，，2： | 1 |
| 14 | Guidelines for the prevention of intravascular catheter-related infections显示文摘 | Naomi P. O’Grady Mary Alexander Lillian A. Burns E. Patchen Dellinger Jeffrey Garland Stephen O. Heard Pamela A. Lipsett Henry Masur Leonard A. Mermel Michele L. Pearson Issam I. Raad Adrienne G. Randolph Mark E. Rupp Sanjay Saint | 2011 | AJIC: American Journal of Infection Control2011，，4： | 1 |
| 15 | A comment on recent teach- ing of human anatomy in the United States显示文摘 | Cahill DR Leonard RJ Marks Jr SC | 2000 | Surg Radiol Anat2000，22，2： | 1 |
| 16 | Kernel PCA for Feature Extraction and De-Noising in Nonlinear Regression显示文摘 | Roman Rosipal Mark Girolami Leonard J. Trejo Andrzej Cichocki | 2001 | Neural Computing & Applications2001，，3： | 1 |
| 17 | AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram显示文摘 | Galen S. Wagner Peter Macfarlane Hein Wellens Mark Josephson Anton Gorgels David M. Mirvis Olle Pahlm Borys Surawicz Paul Kligfield Rory Childers Leonard S. Gettes | 2009 | Journal of the American College of Cardiology2009，，11： | 1 |
| 18 | Barrett’s esophagus: cancer and molecular biology显示文摘 | Michael K. Gibson Arashinder S. Dhaliwal Nicholas J. Clemons Wayne A. Phillips Katerina Dvorak Daniel Tong Simon Law E. Daniel Pirchi Jari R?s?nen Mark J. Krasna Kaushal Parikh Kausilia K. Krishnadath Yu Chen Leonard Griffiths Benjamin J. Colleypriest J. | 2013 | Ann. N.Y. Acad. Sci2013，，1： | 1 |
| 19 | Conservative Management of Adolescent Varicoceles: A Retrospective Review显示文摘 | Mark A. Preston Toby Carnat Trevor Flood Isabelle Gaboury Michael P. Leonard | 2008 | Urology2008，，1： | 1 |
| 20 | Effect of Composition on the Electromechanical Properties of (1-x)Pb( Mg1/3 Nb2/3)O3-xPbTiO3 Ceramics显示文摘 | Joe Kelly Mark Leonard Chutima Tantigate | 1997 | Journal of the American Ceramic Society1997，80，4： | 1 |
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