5篇
您的检索式：作者名="Mark Payton"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis显示文摘AIM To investigate gender-specific liver estrogen receptor(ER) expression in normal subjects and patients with hepatitis C virus(HCV)-related cirrhosis and hepatocellular carcinoma(HCC).METHODS Liver tissues from normal donors and patients diagnosed with HCV-related cirrhosis and HCV-related HCC were obtained from the NIH Liver Tissue and Cell Distribution System. The expression of ER subtypes, ERα and ERβ, were evaluated by Western blotting and real-time RT-PCR. The subcellular distribution of ERα and ERβ was further determined in nuclear and cytoplasmic tissue lysates along with the expression ofinflammatory [activated NF-κB and IκB-kinase(IKK)] and oncogenic(cyclin D1) markers by Western blotting and immunohistochemistry. The expression of ERα and ERβ was correlated with the expression of activated NF-κB, activated IKK and cyclin D1 by Spearman's correlation. RESULTS Both ER subtypes were expressed in normal livers but male livers showed significantly higher expression of ERα than females(P < 0.05). We observed significantly higher m RNA expression of ERα in HCV-related HCC liver tissues as compared to normals(P < 0.05) and ERβ in livers of HCV-related cirrhosis and HCV-related HCC subjects(P < 0.05). At the protein level, there was a significantly higher expression of nuclear ERα in livers of HCV-related HCC patients and nuclear ERβ in HCV-related cirrhosis patients as compared to normals(P < 0.05). Furthermore, we observed a significantly higher expression of phosphorylated NF-κB and cyclin D1 in diseased livers(P < 0.05). There was a positive correlation between the expression of nuclear ER subtypes and nuclear cyclin D1 and a negative correlation between cytoplasmic ER subtypes and cytoplasmic phosphorylated IKK in HCV-related HCC livers. These findings suggest that dysregulated expression of ER subtypes following chronic HCVinfection may contribute to the progression of HCVrelated cirrhosis to HCV-related HCC.CONCLUSION Gender differences were observed in ERα expression in normal livers. Alterations in ER subtype expression observed in diseased livers may influence genderrelated disparity in HCV-related pathogenesis. | Janaki K Iyer Mamta Kalra Anil Kaul Mark E Payton Rashmi Kaul | 2017 | World Journal of Gastroenterology2017，23，37： | 5 |
| 2 | Daily Apple versus Dried Plum: Impact on Cardiovascular Disease Risk Factors in Postmenopausal Women显示文摘 | Sheau C. Chai Shirin Hooshmand Raz L. Saadat Mark E. Payton Kenneth Brummel-Smith Bahram H. Arjmandi | 2012 | Journal of the Academy of Nutrition and Dietetics2012，，8： | 1 |
| 3 | Role of the virion host shutoff protein in neurovirulence of monkey B virus(Macacine herpesvirus 1)显示文摘Monkey B virus(Macacine herpesvirus 1; BV) is noted for its extreme neurovirulence in humans. Since the vhs protein encoded by the UL41 gene has been shown to be a neurovirulence factor in the related human herpes simplex viruses, the role of the UL41 gene in BV neurovirulence was investigated. BV mutants were constructed that lacked the entire UL41 ORF(Δ41) or had the RNase active site mutated(Δ41A). Neither mutant shut off host protein synthesis, degraded β-actin mRNA, or prevented an IFN-β response, indicating that the vhs protein and its RNase activity are both necessary for these activities. Replication of both mutants in primary mouse cells was impaired and they exhibited a prolonged disease course in mice. Whereas Δ41 infected mice were euthanized for symptoms related to central nervous system(CNS) infection, Δ41A infected mice were euthanized primarily for symptoms of autonomic nervous system dysfunction. While neuroinvasiveness was not affected, lesions in the CNS were more limited in size, anatomical distribution, and severity than for wild-type virus. These results indicate that the vhs protein affects the general replicative efficiency of BV in vivo rather than being a specific neurovirulence factor critical for invasion of or preferential replication in the CNS. | Darla Black Jerry Ritchey Mark Payton Richard Eberle | 2014 | Virologica Sinica2014，29，5： | 1 |
| 4 | Response of calves persistently infected with noncytopathic bovine viral diarrhea virus (BVDV) subtype 1b after vaccination with heterologous BVDV strains in modified live virus vaccines and Mannheimia haemolytica bacterin-toxoid显示文摘 | Robert W. Fulton Douglas L. Step Julia F. Ridpath Jeremiah T. Saliki Anthony W. Confer Bill J. Johnson Robert E. Briggs R.V. Hawley Lurinda J. Burge Mark E. Payton | 2003 | Vaccine2003，，21： | 1 |
| 5 | SGT1 Is Induced by the Potato virus X TGBp3 and Enhances Virus Accumulation in Nicotiana benthamiana显示文摘 | Chang-Ming Ye Vicky Kelly Mark Payton Martin B. Dickman Jeanmarie Verchot | 2012 | Molecular Plant2012，5，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员