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| 1 | Predictors of mortality after transjugular portosystemic shunt显示文摘AIM:To investigate if echocardiographic and hemodynamic determinations obtained at the time of transjugular intrahepatic portosystemic shunt(TIPS)can provide prognostic information that will enhance risk stratification of patients.METHODS:We reviewed medical records of 467 patients who underwent TIPS between July 2003 and December 2011 at our institution.We recorded information regarding patient demographics,underlying liver disease,indication for TIPS,baseline laboratory values,hemodynamic determinations at the time of TIPS,and echocardiographic measurements both before and after TIPS.We recorded patient comorbidities that may affect hemodynamic and echocardiographic determinations.We also calculated Model for Endstage Liver Disease(MELD)score and Child Turcotte Pugh(CTP)class.The following pre-and post-TIPS echocardiographic determinations were recorded:Left ventricular ejection fraction,right ventricular(RV)systolic pressure,subjective RV dilation,and subjective RV function.We recorded the following hemodynamic measurements:Right atrial(RA)pressure before and after TIPS,inferior vena cava pressure before and after TIPS,free hepatic vein pressure,portal vein pressure before and after TIPS,and hepatic venous pressure gradient(HVPG).RESULTS:We reviewed 418 patients with portal hypertension undergoing TIPS.RA pressure increased by a mean ± SD of 4.8 ± 3.9 mmH g(P < 0.001),HVPG decreased by 6.8 ± 3.5 mmH g(P < 0.001).In multivariate linear regression analysis,a higher MELD score,lower platelet count,splenectomy and a higher portal vein pressure were independent predictors of higher RA pressure(R = 0.55).Three variables predicted 3-mo mortality after TIPS in a multivariate analysis:Age,MELD score,and CTP grade C.Change in the RA pressure after TIPS predicted long-term mortality(per 1 mm Hg change,HR = 1.03,95%CI:1.01-1.06,P < 0.012).CONCLUSION:RA pressure increased immediately after TIPS particularly in patients with worse liver function,portal hypertension,emergent TIPS placement and history of splenectomy.The increase in RA pressure after TIPS was associated with increased mortality.Age,splenectomy,MELD score and CTP grade were independent predictors of long-term mortality after TIPS. | Mona Ascha Sami Abuqayyas Ibrahim Hanouneh Laith Alkukhun Mark Sands Raed A Dweik Adriano R Tonelli | 2016 | World Journal of Hepatology2016，8，11： | 13 |
| 2 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 3 | 不同肤色人种角层细胞黑素含量和形态的比较显示文摘目的 探讨种族间皮肤角层细胞黑素的差异。方法 用浅表角层细胞粘附技术和 Optomax V计算机分析系统对一组黑种人 (10名 ),白种人 (24名 )和黄种人 (13名 )暴光区和非暴光区皮肤浅表角层黑素细胞进行定量分析和观察。结果 3个种族间皮肤浅表角层细胞黑素含量存在明显差异 (暴光区 F=12.4。 | 陆洪光 Pearse A Marks R | 2000 | 中华皮肤科杂志2000，33，4： | 7 |
| 4 | Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders显示文摘Deep brain stimulation(DBS) is emerging as a pow-erful tool for the alleviation of targeted symptoms in treatment-resistant neuropsychiatric disorders. Despite the expanding use of neuropsychiatric DBS, the mecha-nisms responsible for its effects are only starting to be elucidated. Several modalities such as quantitative elec-troencephalography as well a intraoperative recordings have been utilized to attempt to understand the under-pinnings of this new treatment modality, but functional imaging appears to offer several unique advantages. Functional imaging techniques like positron emission tomography, single photon emission computed tomog-raphy and functional magnetic resonance imaging have been used to examine the effects of focal DBS on activ-ity in a distributed neural network. These investigations are critical for advancing the field of invasive neuro-modulation in a safe and effective manner, particularly in terms of defining the neuroanatomical targets and refining the stimulation protocols. The purpose of this review is to summarize the current functional neuroim-aging findings from neuropsychiatric DBS implantation for three disorders: treatment-resistant depression, obsessive-compulsive disorder, and Tourette syndrome. All of the major targets will be discussed(Nucleus ac-cumbens, anterior limb of internal capsule, subcallosal cingulate, Subthalamic nucleus, Centromedial nucleus of the thalamus-Parafasicular complex, frontal pole, and dorsolateral prefrontal cortex). We will also address some apparent inconsistencies within this literature, and suggest potential future directions for this promis-ing area. | Nolan R Williams Joseph J Taylor Kayla Lamb Colleen A Hanlon E Baron Short Mark S George | 2014 | World Journal of Radiology2014，6，10： | 6 |
| 5 | 伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。 | Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
| 6 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 7 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 8 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 9 | The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years显示文摘 | Mark R Nelson Christine Katlama Julio S Montaner David A Cooper Brian Gazzard Bonaventura Clotet Adriano Lazzarin Knud Schewe Joep Lange Christina Wyatt Sue Curtis Shan-Shan Chen Stephen Smith Norbert Bischofberger James F Rooney | 2007 | AIDS2007，，10： | 2 |
| 10 | Tolllike receptor2 m ediates lipopolysaccharides induced cellular signaling显示文摘 | Yan R B Mark M R Gray A | 1998 | Nature1998，395，： | 2 |
| 11 | Sand dunes as potential sources of dust in northern China显示文摘While saltation bombardment of sand grains on a fine substrate can produce considerable dust, the well-sorted nature of sand dunes tends to preclude them from consideration as major dust sources. Recent research, however, has revealed that sand dunes can, in some cases, be large sources of dust. We used the PI-SWERL(Portable In-Situ Wind Erosion Laboratory) to measure in the field the potential of sand dunes and other desert landforms to emit particulate matter <10 μm(PM-10) dust in the Tengger, Ulan Buh, and Mu Us deserts of northern China. Combined with high resolution particle size measurements of the dune sand, an assessment of sand dunes as a dust source can be made. Large active transverse dunes tend to contain little to no stored PM-10, yet they produce a low dust flux. Coppice dunes stabilized by vegetation contain appreciable PM-10 and have very high dust emission potential. There is a positive correlation between the amount of PM-10 stored in a dune and its potential dust flux. Saltation liberates loose fines stored in dunes, making them very efficient dust emitters compared to landforms such as dry lake beds and washes where dust particles are unavailable for aeolian transport due to protective crusts or sediment cohesion. In cases where large dunes do not store PM-10 yet emit dust when active, two hypotheses can be considered:(1) iron-oxide grain coatings are removed during saltation, creating dust, and(2) sand grains collide during saltation, abrading grains to create dust. Observations reveal that iron oxide coatings are present on some dune sands. PI-SWERL data suggests that low dust fluxes from dunes containing no stored dust may represent an estimate for the amount of PM-10 dust produced by removal of iron oxide coatings. These results are similar to results from dunes in the United States. In addition, PI-SWERL results suggest that dust-bearing coppice dunes, which cover vast areas of China's sandy deserts, may become major sources of dust in the future if overgrazing, depletion of groundwater, or drought destabilizes the vegetation that now partially covers these dunes. | Mark R SWEENEY LU HuaYu CUI MengChun Joseph A MASON FENG Han XU ZhiWei | 2016 | Science China Earth Sciences2016，59，4： | 2 |
| 12 | Electric load forecasting using an artificial neural network 显示文摘 | Park D C El-Sharkawi M A Marks R J | 1991 | IEEE Transactions on Power Systems1991，6，2： | 2 |
| 13 | Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity显示文摘 | Muhammad A Cowley Andrew R Moloney Mark G | 2010 | Tetrahedron: Asymmetry2010，21，1314： | 1 |
| 14 | Deposition and investi gation of functionally graded calcium phosphate coatings on titanium 显示文摘 | Rabiei Stefan S Mark R A | 2009 | Acta Biomaterialia2009，5，9： | 1 |
| 15 | Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis 显示文摘 | Pandey A Shao H Marks R M | 1995 | Science1995，268，5210： | 1 |
| 16 | Humoral immuno- globulins of the white sturgeon (Acipenser transmon- tanus):partial characterization of and recognition with monoclonal antibodies显示文摘 | Mark A Bascureo B Hedrick R P | 1996 | Developmental & Compar- ative Immunology1996，20，4： | 1 |
| 17 | Toll-like receptor 2 mediates lipoplysaccharide-induced celluar signalling 显示文摘 | Yang R B Mark M R Gray A | 1998 | Nature1998，395，6699： | 1 |
| 18 | Electric load forecasting using an artificial neural network 显示文摘 | EI-Sharkawi M A Marks R J II Atlas L E | 1991 | IEEE Transactions on Power System1991，6，2： | 1 |
| 19 | Effects of antiagglomerants on the interactions between hydrate particles显示文摘 | Mark R A J Dalton Y Luke H | 2007 | American Institute of Chemical Engineers2007，54，2： | 1 |
| 20 | Synthesis of poly (tetramethylm-silphenylenesiloxane),an elastomer of enhanced high-temperature stabilityl显示文摘 | Zhang R Pinhas A R Mark J E | 1997 | Macromolecules1997，30，8： | 1 |
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