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| 1 | Testicular expression of survivin and human telomerase reverse transcriptase(hTERT)associated with spermatogenic function in infertile patients显示文摘瞄准:与改变精子发生的功能在人的睾丸描绘 survivin, apoptosis (国际星际航空联合会) 的一个禁止者,和人的 telomerase 颠倒 transcriptase (hTERT ) 的 coexpression。方法:survivin mRNA 和 hTERT mRNA 的抄本层次用即时反向抄写的聚合酶链反应(RT-PCR ) 与有缺点的精子发生(n=28 ) 在正常睾丸(n=11 ) 和睾丸被决定。组织学的病情的检查根据一个修改 Johnsen 分数被执行。结果:survivin 和 hTERT 的表情在正常精子发生在 96.8 和 709 的中部的层次是最高的并且随减数分裂后精子发生的拘捕(n=10 ) 在睾丸落下到 53.3 和 534。在严重精子发生的失败( n=18 ), survivin 表示缺乏大多数标本( n=16 ),而阴囊的 hTERT 表示的至少底层在 premeiotic 精子发生的拘捕( n=7 )与 73 的规范的表情大部分是可检测的并且 45 在有 Sertoli 房间唯一的症候群( SCOS )( n=3 )的病人。survivin 和 hTERT 表情与一个进行的 Johnsen 分数(为 trend=0.001 的 P ) 增加了。结论:尽管 survivin 和 hTERT 与精子发生的功能被相关,他们在不肥沃的病人的睾丸显示出不同表示模式。这些调查结果在在 meiotically 划分生殖细胞建议 survivin 的占优势的表情的啮齿类动物睾丸从研究证实结果。 | Steffen Weikert Frank Christoph Wolfgang Schulze Hans Krause Carsten Kempkensteffen Martin Schostak Kurt Miller Mark Schrader | 2006 | Asian Journal of Andrology2006，8，1： | 8 |
| 2 | Quantification of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA in testicular tissue of infertile patients显示文摘Aim: To evaluate the quantitative detection of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA as diagnostic parameters in the workup of testicular tissue specimens from patients presenting with non-obstructive azoospemia. Methods: hTR and hTERT mRNA expression were quantified in 38 cryopreserved testicular tissue specimens by fluorescence real-time reverse transcription- polymerase chain reaction (RT-PCR)in a LightCycler(r). This was paralleled by conventional histological workup in all tissue specimens and additional semithin sectioning preparation in cases with maturation arrest ( n = 12) and Sertoli-cell-only syndrome ( n = 12). Results: The average normalized hTERT expression (NhTERT) Was 131.9 ± 48.0 copies (mean ± SD) in tissue specimens with full spermatogenesis, NhTERT = 51.2 ± 17.2 copies in those with maturation arrest and NhTERT = 2.7 ± 2.4 copies in those with Sertoli-cell-only syndrome (SCOS). The discriminant analysis showed that detection of NhTERT (NhTR) had a predictive value of 86.8 % (55.3 % ) for correct classification in one of the three histological subgroups.Conclusion: Our results demonstrate that quantitative detection of hTERT mRNA expression in testicular tissue enables a molecular-diagnostic classification of gametogenesis. Quantitative detection of hTERT in testicular biopsies is thus well suited for supplementing the histopathological evaluation. | Mark Schrader Markus Müller Rüdiger Heicappell Bernd Straub Kurt Miller | 2001 | Asian Journal of Andrology2001，3，4： | 3 |
| 3 | Nitrite Regulates Hypoxic Vasodilation via Myoglobin-Dependent Nitric Oxide Generation显示文摘 | Matthias Totzeck Ulrike B. Hendgen-Cotta Peter Luedike Michael Berenbrink Johann P. Klare Heinz-Juergen Steinhoff Dominik Semmler Sruti Shiva Daryl Williams Anja Kipar Mark T. Gladwin Juergen Schrader Malte Kelm Andrew R. Cossins Tienush Rassaf | 2012 | Circulation2012，，3： | 2 |
| 4 | Serum amyloid A as indicator of distant metastases but not as early tumor marker in patients with renal cell carcinoma显示文摘 | Azizbek Ramankulov Michael Lein Manfred Johannsen Mark Schrader Kurt Miller Stefan A. Loening Klaus Jung | 2008 | Cancer Letters2008，，1： | 1 |
| 5 | Consumer reactance against loyalty programs显示文摘 | Mark Wendlandt Ulf Schrader | 2007 | Journal of Consumer Marketing2007，，5： | 1 |
| 6 | Neoadjuvant therapy of renal cell carcinoma: A novel treatment option in the era of targeted therapy?显示文摘 | Andres J Schrader Sandra Steffens Thomas J Schnoeller Mark Schrader Markus A Kuczyk | 2012 | International Journal of Urology2012，，： | 1 |
| 7 | Enzalutamide in Castration-resistant Prostate Cancer Patients Progressing After Docetaxel and Abiraterone显示文摘 | Andres Jan Schrader Martin Boegemann Carsten-H. Ohlmann Thomas J. Schnoeller Laura-Maria Krabbe Turkan Hajili Florian Jentzmik Michael Stoeckle Mark Schrader Edwin Herrmann Marcus V. Cronauer | 2013 | European Urology2013，，： | 1 |
| 8 | Heat shock protein 90 is a promising target for effective growth inhibitionof gastrointestinal neuroendocrine tumors显示文摘 | Christoph Gloesenkamp Bianca Nitzsche Alice Lim Emmanuel Normant Evan Vosburgh Mark Schrader Matthias Ocker Hans Scherübl Michael H?pfner | 2012 | International Journal of Oncology2012，，： | 1 |
| 9 | A gene expression profile of tumor suppressor genes commonly methylated in bladder cancer显示文摘 | Frank Christoph Stefan Hinz Carsten Kempkensteffen Steffen Weikert Hans Krause Martin Schostak Mark Schrader Kurt Miller | 2007 | Journal of Cancer Research and Clinical Oncology2007，，6： | 1 |
| 10 | 腹腔镜肾部分切除术治疗局限性肾细胞癌27例显示文摘目的:探讨经腹腔镜肾部分切除术治疗局限性肾细胞癌的手术技巧和近期疗效。方法:选择T1期、单发肿瘤,平均肿瘤直径4.0 cm(3.0~7.0 cm)的局限性肾细胞癌27例,术中用内镜bulldog钳阻断肾动脉;用剪刀或超声刀在距离肿瘤边缘0.5~1.0 cm处进行局部切除;肾切除床内置Surgicel薄片卷垫后,间断缝合肾实质,创面边缘喷涂FloSeal明胶基质以防延迟出血。术中冰冻确定切缘阴性。结果:27例手术均获成功,无术中、术后并发症。手术时间平均110 min;热缺血时间20~55 min,平均32 min;术中出血量平均150 mL。术后随访平均6个月,未见肿瘤局部复发,未见转移。结论:腹腔镜肾部分切除术治疗局限性肾细胞癌安全可靠,短期随访效果肯定。 | 傅全胜 Serdar Deger Michael Lein Mark Schrader | 2010 | 暨南大学学报(自然科学与医学版)2010，31，4： | 0 |
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