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您的检索式：作者名="Markus Nolte"
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| 1 | Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling显示文摘Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D,1,25-dihydroxy-vitamin D [1,25(OH)2 D] are mediated through binding to the vitamin D receptor(VDR). Here,we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad(MDA-MB-231),subcutaneously(PC3) or intra-tibially(both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls.These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/β-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1,interleukin-6(IL-6), and IL-8. Stabilization of β-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer. | Yu Zheng Trupti Trivedi Ruby CY Lin Colette Fong-Yee Rick Nolte Jeline Manibo Yunzhao Chen Musharraf Hossain Konstantin Horas Colin Dunstan Hong Zhou Markus J Seibel | 2017 | Bone Research2017，5，3： | 4 |
| 2 | Elevated Serum Levels of Astroglial S100β in Patients with Liver Cirrhosis Indicate Early and Subclinical Portal-Systemic Encephalopathy显示文摘 | Jens Wiltfang Wilhelm Nolte Markus Otto Jens Wildberg Erik Bahn Hans Reiner Figulla Lars Pralle Heinz Hartmann Eckhard Rüther Giuliano Ramadori | 1999 | Metabolic Brain Disease1999，，4： | 1 |
| 3 | Net-net Shape Processing of Continuous Fiber-renforced Aluminum显示文摘 | Markus Nolte Eric Neussl Peter R Sahm | 1995 | Key Engineering Materials1995，，： | 1 |
| 4 | 一种用于高阶W态制备的新颖量子集成线路及其高精度表征(英文)显示文摘多粒子纠缠态(如W态)在量子计算、真随机数产生等方面有着广泛的应用空间,因此受到越来越多的关注.其中W态纠缠还具有显著的抗退相干性.本文提出一种用于产生高阶单光子W态的通用实验装置,这种装置基于由激光直写制备的三维集成光子波导结构.此外,由于在量子光学中,通常需要精确表征量子元件的幺正矩阵,本文提出一种新颖的方法,即使用传统的光干涉测量法实现这种表征.对于幺正矩阵元,分别使用强度测量和基于利萨如图形的高灵敏度相位测量获得其模和幅角.在这种方法中,相位测量的复杂程度与通道数量呈线性关系,因而也适用于表征通道更多的量子元件.实验表明,该方法可以高精度地表征W态制备装置中量子门的保真度. | Ren Heilmann Markus Gra¨ fe Stefan Nolte Alexander Szameit | 2015 | Science Bulletin2015，60，1： | 0 |
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