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| 1 | Ribavirin:Past,present and future显示文摘Before the advent of direct acting antiviral agents(DAAs) ribavirin, associated to pegylated-interferon played a crucial role in the treatment of chronic hepatitis C, preventing relapses and breakthroughs. In the present era of new potent DAAs, a place is still devoted to the drug. Ribavirin associated with sofosbuvir alone is efficient in the treatment of most cases of G2 infected patients. All options currently available for the last difficult-to-treat cirrhotic G3 patients contain ribavirin. Reducing treatment duration to 12 wk in G1 or G4 cirrhotic compensated patients is feasible thanks to ribavirin. Retreating patients with acquired anti NS5 A resistance-associated variants using ribavirin-based strategies could be useful. The addition of ribavirin with DAAs combinations however, leads to more frequent but mild adverse events especially in cirrhotic patients. Preliminary data with interferon-free second generation DAAs combinations without ribavirin suggest that future of the drug is jeopardized even in difficult-totreat patients: The optimization of ribavirin dosage according to an early monitoring of blood levels has been suggested to be relevant in double therapy with peginterferon or sofosbuvir but not with very potent combinations of more than two DAAs. | Véronique Loustaud-Ratti Marilyne Debette-Gratien Jérémie Jacques Sophie Alain Pierre Marquet DenisSautereau Annick Rousseau Paul Carrier | 2016 | World Journal of Hepatology2016，8，2： | 3 |
| 2 | HCV ‐associated B ‐cell non‐ H odgkin lymphomas and new direct antiviral agents显示文摘 | Paul Carrier Arnaud Jaccard Jérémie Jacques Tessa Tabouret Marilyne Debette‐Gratien Julie Abraham Laura Mesturoux Pierre Marquet Sophie Alain Denis Sautereau Marie Essig Véronique Loustaud‐Ratti | 2015 | Liver Int2015，，10： | 2 |
| 3 | Reduction of Peritoneal Trauma By Using Nonsurgical Gauze Leads to Less Implantation Metastasis of Spilled Tumor Cells显示文摘 | Petrousjka M. van den Tol Elma E. M. van Rossen Casper H. J. van Eijck Fred Bonthuis Richard L. Marquet Hans Jeekel | 1998 | Annals of Surgery1998，，2： | 2 |
| 4 | Why Is the Climate Forcing of Sulfate Aerosols So Uncertain?显示文摘Sulfate aerosol particles have strong scattering effect on the solar radiation transfer which results in in- creasing the planet albedo and, hence, tend to cool the earth-atmosphere system, Also, aerosols can act as the cloud condensation nuclei (CCN) which tend to increase the albedo of clouds and cool the global warm- ing. The ARPEGE-Climat version 3 AGCM with FMR radiation scheme is used to estimate the direct and indirect radiative forcing of sulfate aerosols. For minimizing the uncertainties in assessing this kind of cool- ing effect, all kinds of factors are analyzed which have been mixed in the assessment process and may lead to the different results of the radiative forcing of aerosols, It is noticed that one of the uncertainties to assess the climate forcing of aerosols by GCM results from the different definition of radiative forcing that was used. In order to clarify this vague idea, the off-line case for considering no feedbacks and on-line case for including all the feedbacks have been used for assessment. The direct forcing of sulfate aerosols in off-line case is -0.57 W/ m2 and -0.38 W / m2 for the clear sky and all sky respectively. The value of on-line case appears to be a little larger than that in off-line case chiefly due to the feedback of clouds. The indirect forc- ing of sulfate aerosols in off line case is -1 .4 W / m2 and -1 .0 W / m2 in on-line case. The radiative forcing of sulfate aerosols has obvious regional characteristics. There is a larger negative radiative forcing over North America, Europe and East Asia. If the direct and indirect forcing are added together, it is enough to offset the positive radiative forcing induced by the greenhouse gases in these regions. | Hu Rongming, Serge Planton, Michel Deque, Pascal Marquet and Alain Braun Centre national de recherches m t orologiques, Meteo-France | 2001 | Advances in Atmospheric Sciences2001，18，6： | 2 |
| 5 | Advances in the structural understanding of Vif proteins 显示文摘 | Barraud P Paillart J Marquet R | 2008 | Curr HIV Res2008，6，： | 1 |
| 6 | The expression of macrophage migration inhibitory factorl-alpha (MIFlalpha) in human atherosclerotic plaques is induced by different proatherogenic stimuli and associated with plaque instability 显示文摘 | Schmeisser A Marquetant R Illmer T | 2005 | Atherosclerosis2005，178，1： | 1 |
| 7 | Barriers to hospice care and referrals: survey of physicians' knowledge,attitudes, and perception in a health maintenance organization显示文摘 | Brickner L Scannell K Marquet S | 2004 | J Pal- liate Med2004，7，3： | 1 |
| 8 | Simultaneous amplitude-contrast and quantitative phase-contrast microscopy by numerical reconst ruction of Fresnel off-axis holograms 显示文摘 | Cuche E Marquet P Depeursinge C | 1999 | Appl Opt1999，38，34： | 1 |
| 9 | Barriers to hospice care and referrals: survey of physicians' knowledge, attitudes, and perception in a health maintenance organization显示文摘 | Brickner L Scannell K Marquet S | 2004 | J Palliate Med2004，7，3： | 1 |
| 10 | Simultaneous determination of four anthracyclines and three metabolites in human serum by liquid chromatography-electrospray mass spectrometry显示文摘 | Lachatre F Marquet P Ragot S | 2000 | J Chromatogr B2000，738，2： | 1 |
| 11 | The expression of macrophage migration inhibitory factor 1alpha (MIF 1alpha) in human atherosclerotic plaques is induced by different proatherogenic stimuli and associated with plaque instability 显示文摘 | Schmeisser A Marquetant R Illmer T | 2005 | Atherosclerosis2005，178，1： | 1 |
| 12 | Aperture apodization using cubic spline interpolation: application in digital holographic microscopy 显示文摘 | E Cuche P Marquet C Depeursinge | 2000 | Opt Commun2000，182，1： | 1 |
| 13 | Tumor recurrence in liver grafts:two animal models显示文摘 | Schotman SN van Ijken MG Marquet RL | 1998 | Transplant Proc1998，30，4： | 1 |
| 14 | Laparoscopic surger in the rat:beneficial effect on body weight and tumor take显示文摘 | Marquet RL Hamming JF | 1996 | Surg Endosc1996，10，： | 1 |
| 15 | Application of pharmacokinetic modelling to the routine therapeutic drug monitoring of anticancer drugs 显示文摘 | Marquet P | 2002 | Fundam Clin Pharmacol2002，16，4： | 1 |
| 16 | Primary nonfunction of islet xenografts:the role of macrophages 显示文摘 | Marquet RL Bonthuis F Van IJken M | 1994 | Transpl Int1994，，1： | 1 |
| 17 | Sensitive and specific multi-residue methods for determination of pesticides of various classes in clinical and forensic toxicology 显示文摘 | Lacassie E Marquet P Gaulier JM | 2001 | Forensic Science Int2001，121，： | 1 |
| 18 | Extracorporeal perfusion for the treatment of acute liver failure显示文摘 | STOCKMANN H B HIEMSTRA C A MARQUET R L | 2000 | Ann Surg2000，231，4： | 1 |
| 19 | Six New Fungicide Substances Presented at an AFPP Conference on Plant Diseases显示文摘 | MARQUET N | 2007 | Phytoma2007，600，： | 1 |
| 20 | Invariants, scaling laws, and ecological complexity 显示文摘 | Marquet P A | 2000 | Science2000，289，： | 1 |
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