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| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | U-tility of qualitative C - reactive protein assay and white blood cells counts in the diagnosis of neonatal septicaemia at Bugando Medical Centre, Tanzania 显示文摘 | Flora Chacha Mariam M Mirambo Martha F Mushi | 2014 | BMC Pediatrics2014，14，6： | 1 |
| 3 | Solar radiation, longwave radiation and emergent wetland evapotranspiration estimates from satellite data in Florida, USA显示文摘 | Martha C A Lee C F | 2004 | Hydrological Sciences2004，49，3： | 1 |
| 4 | Tumefactive multiple sclerosis: an uncommon diagnostic challenge显示文摘 | Martha A Kaeser DC Scali F | 2011 | J Chiropr Med2011，10，： | 1 |
| 5 | Direct administration of insulin-like growthfactor to fetal rhesus monkeys B (macacamulat-ta) 显示文摘 | Tarantal A F Marthas M M L Gargosky S E | 1997 | Endocrnol1997，138，8： | 1 |
| 6 | Surface mesh regeneration considering curvatures 显示文摘 | Miranda A C O Martha L F Wawrzynek P A etal | 2009 | Engineering with Computers2009，25，2： | 1 |
| 7 | Polymorphic variation of the guanosine triphosphate cyclo- hydrolase 1 gene predicts outcome in patients undergoing surgi-cal treatment for lumbar degenerative disc disease 显示文摘 | Kim D H Dai F Belfer I Banco R J Martha J F Tighiouart H | 2010 | Spine (Phila Pa 1976)2010，35，： | 1 |
| 8 | Increased auditory startle response and reduced prepulse inhibition of strtle in transgenic mice expressing a double mutant form of any loid precursor protein显示文摘 | Martha F Geoffrey B Robert A | 2003 | Brain Research2003，994，1： | 1 |
| 9 | Skin tears:care and management of the older adult at home显示文摘 | Regina F Martha W Bonnie J | 2013 | Home Healthcare Nurse2013，31，2： | 1 |
| 10 | Remediation of pesticide contaminated soil using TiO 2 mediated by solar light显示文摘 | Martha M Higarashi Wilson F Jardim | 2002 | Catalysis Today2002，，2： | 1 |
| 11 | Association of catechol-O-methyltrans- ferase genetic variants with outcome in patients undergoing sur-gical treatment for lumbar degenerative disc disease显示文摘 | Dai F Belfer I Schwartz C E Banco R Martha J F Tighioughart H | 2010 | Spine J2010，10，： | 1 |
| 12 | Prognostic value of the Duke treamill score in asymptomatlc women 显示文摘 | Martha G Morton F Leslee J | 2005 | J Am Coll Cardiol2005，96，： | 1 |
| 13 | Prospective Evaluation of Chronic Pain Associated with Posterior Autologous Iliac Crest Bone Graft Harvest and Its Effect on Postoperative Outcome显示文摘 | Schwartz C E Martha J F Kowalski P | 2009 | Health Qual Life Outcomes2009，29，7： | 1 |
| 14 | Effects of hydrazine derivatives on vascular smooth muscle contrac- tility, blood pressure and cGMP production in rats : compari- son with hydralazine 显示文摘 | HORACIO V GABRIAELA F MARTHA M | 2003 | Vascular Pharmacology2003，，： | 1 |
| 15 | On the transformation behaviour, mechanical properties and biocompatibility of two NiTi- based shape memory alloys: NiTi42 and NiTi42Cu7 显示文摘 | Es-Souni M Es-Souni Martha Brandies H F | 2001 | Biomaterials2001，22，15： | 1 |
| 16 | A reagentless enzymatic amperometric biosensor using vertically aligned carbon nanofibers ( VACNF ) 显示文摘 | Martha L W Touhidur R Paul D F | 2008 | Sens Actuators B :Chemical2008，133，1： | 1 |
| 17 | MicroRNA 21 Blocks Apoptosis in Mouse Periovulatory Granulosa Cells显示文摘 | Martha Z C Stephanie D F Lane K C | 2010 | Biolo gy of Reprodution2010，83，： | 1 |
| 18 | Blockade of tissue factor显示文摘 | Martha S C Welty-Wolf K F Debra L M | 2003 | Am Respir Crit Care Med2003，167，： | 1 |
| 19 | Elucidating the role of phenolic compounds in the effectiveness of DOM adsorption on novel tailored activated carbon 显示文摘 | LIANG Yan MARTHA F CINDY K | 2013 | Journal of Hazardous Materials2013，262，8： | 1 |
| 20 | High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy显示文摘BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation therapy.Due to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor growth.Transarterial chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in LT.However,it remains unclear if one of those treatment options is superior.The analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by histopathology.AIM To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT alone.METHODS In this multicenter retrospective study,27 patients who received liver transplantation for HCC were analyzed.Patients received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver transplantation.Liver explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging therapies.Statistical analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and Mann-Whitney-U tests.RESULTS Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and SBRT.There were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor lesions.Strikingly,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests that a combination of TACE and SBRT increases the rate of complete histopathological response compared to TACE or SBRT alone in bridging to liver transplantation. | Ulrike Bauer Sabine Gerum Falk Roeder Stefan Münch Stephanie E Combs Alexander B Philipp Enrico N De Toni Martha M Kirstein Arndt Vogel Carolin Mogler Bernhard Haller Jens Neumann Rickmer F Braren Marcus R Makowski Philipp Paprottka Markus Guba Fabian Geisler Roland M Schmid Andreas Umgelter Ursula Ehmer | 2021 | World Journal of Gastroenterology2021，27，24： | 1 |
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