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| 1 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | Cost anal- ysis of open radical cystectomy versus robot-assisted radi- cal eysteetomy显示文摘 | Mmeje CO Martin AD Nunez-Nateras R | 2013 | Curt Urol Rep2013，14，1： | 1 |
| 3 | The Export Effect of Immigration into the USA 显示文摘 | CO CATHERINE Y Euzent Patricia Martin Thomas | 2004 | Applied Economics2004，36，6： | 1 |
| 4 | AtGRP2, a cold-induced nucleo-cytoplasmic RNA-binding protein, has a role in flower and seed development显示文摘 | Adriana Flores Fusaro Silvia Nora Bocca Rose Lucia Braz Ramos Rosa Maria Barr?co Claudia Magioli Vanessa Cardeal Jorge Tatiana Cardoso Coutinho Camila Martins Rangel-Lima Riet Rycke Dirk Inzé Gilbert Engler Gilberto Sachetto-Martins | 2007 | Planta2007，，6： | 1 |
| 5 | Neuro-ophthalmic findingsin the visual variant of Alzheimer's disease显示文摘 | Lee AG Martin CO | 2004 | Ophthalmology2004，111，： | 1 |
| 6 | Gene discovery in cervical cancer: towards diagnostic and therapeutic biomarkers显示文摘 | Martin CM Kehoe L Spillane CO | 2007 | Mol Diagn Ther2007，11，： | 1 |
| 7 | Adipose tissue mature stem cells in skin healing:a controlled randomized study显示文摘 | Martins PDE Uebel CO Maehado DC | 2011 | Revista Brasileira de Cirurgia Plástica2011，26，3： | 1 |
| 8 | lnterleukin - 1 beta and ad- verse effects on cerebral blood flow during long - term global hypoper- fusian显示文摘 | Maher CO Anderson RE Martin HS | 2003 | J Neurosurg2003，99，5： | 1 |
| 9 | Neonatal brachial plexus palsy: a permanent challenge 显示文摘 | HEISE CO MARTINS R SIQUEIRA M | 2015 | Arq Neurops- iquiatr2015，73，9： | 1 |
| 10 | A prospective study comparing single and double fascicular transfer to re- store elbow flexion after brachial plexus injury显示文摘 | Martins RS Siqueira MG Heise CO | 2013 | Neuro- surgery2013，72，5： | 1 |
| 11 | The thermal benefits of diamond enhanced plastic packages for microwave applications显示文摘 | Sanders A Lockheed Martin Co | 1998 | IEEE1998，，： | 1 |
| 12 | Assisted hatching of human embryos :a systematic review and metaanalysis of randomized controlled trials 显示文摘 | Martins WP Rocha IA Ferriani RA Nastri CO | 2011 | Hum Reprod Update2011，17，： | 1 |
| 13 | Difficult embryo transfers or blood on catheter and assisted reproductive outcomes :a systematic review and meta-analysis显示文摘 | Phillips JA Martins WP Nastri CO Raine-Fenning NJ | 2013 | Eur J Obstet Gynecol Reprod Biol2013，168，： | 1 |
| 14 | Agreement among insulin sensitivity indexes on the diagnosis of insulin resistance in polyeystie ovary syndrome and ovulatory women 显示文摘 | de Paula Martins W Santana LF Nastri CO | 2007 | Eur J Obstet Gyneeol Reprod Biol2007，133，2： | 1 |
| 15 | Gene discovery in cer-vical cancer:towards diagnostic and therapeutic biomarkers显示文摘 | Martin CM Kehoe L Spillane CO | 2007 | J Mol Diagn Ther2007，11，5： | 1 |
| 16 | Pathological laughter and crying: a link to the cerebellum显示文摘 | Parvizi J Anderson SW Martin CO | 2001 | Brain2001，124，： | 1 |
| 17 | Pathological laughter and crying: a link to the cerebellum显示文摘 | Parvizi J Anderson S W Martin CO | 2001 | Brain2001，124，9： | 1 |
| 18 | Difficult embryo transfers or blood on catheter and assisted reproductive out-comes : a systemat- ic review and meta-analysis显示文摘 | Phillips JA Martins WP Nastri CO | 2013 | Eur J Obstet Gynecol Repmd Biol2013，168，2： | 1 |
| 19 | Difficult embryo trans- fers or blood on catheter and assisted reproductive outcomes : a sys- tematic review and meta-analysis 显示文摘 | Phillips JA Martins WP Nastri CO | 2013 | Eur J Obstet Gynecol Re- prod Biol2013，168，2： | 1 |
| 20 | Palhological laughter and crying: a link to the cerebellum显示文摘 | Parvizi J Anderson SW Martin CO | 2001 | Brain2001，125，9： | 1 |
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