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| 1 | Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study显示文摘AIM:To determine the long-term hepatobiliary complications of alveolar echinococcosis(AE) and treatment options using interventional methods.METHODS:Included in the study were 35 patients with AE enrolled in the Echinococcus Multilocularis Data Bank of the University Hospital of Ulm.Patients underwent endoscopic intervention for treatment of hepatobiliary complications between 1979 and 2012.Patients' epidemiologic data, clinical symptoms, and indications for the intervention, the type of intervention and any additional procedures, hepatic laboratory parameters(pre- and post-intervention), medication and surgical treatment(pre- and post-intervention), as well as complications associated with the intervention and patients‘ subsequent clinical courses were analyzed.In order to compare patients with AE with and without history of intervention, data from an additional 322 patients with AE who had not experienced hepatobiliary complications and had not undergone endoscopic intervention were retrieved and analyzed.RESULTS:Included in the study were 22 male and 13 female patients whose average age at first diagnosis was 48.1 years and 52.7 years at the time of intervention.The average time elapsed between first diagnosis and onset of hepatobiliary complications was 3.7 years.The most common symptoms were jaundice, abdominal pains, and weight loss.Thenumber of interventions per patient ranged from one to ten.Endoscopic retrograde cholangiopancreatography(ERCP)was most frequently performed in combination with stent placement(82.9%),followed by percutaneous transhepatic cholangiodrainage(31.4%)and ERCP without stent placement(22.9%).In 14.3%of cases,magnetic resonance cholangiopancreatography was performed.A total of eight patients received a biliary stent.A comparison of biochemical hepatic function parameters at first diagnosis between patients who had or had not undergone intervention revealed that these were significantly elevated in six patients who had undergone intervention.Complications(cholangitis,pancreatitis)occurred in six patients during and in 12patients following the intervention.The average survival following onset of hepatobiliary complications was 8.8years.CONCLUSION:Hepatobiliary complications occur in about 10%of patients.A significant increase in hepatic transaminase concentrations facilitates the diagnosis.Interventional methods represent viable management options. | Tilmann Graeter Franziska Ehing Suemeyra Oeztuerk Richard Andrew Mason Mark Martin Haenle Wolfgang Kratzer Thomas Seufferlein Beate Gruener | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 2 | Overt propositional speech in chronic non-fluent aphasia studied with the dynamic susceptibility contrast fMRI method显示文摘 | Naeser MA Martin PI Baker EH | 2004 | Neuroimage2004，22，： | 1 |
| 3 | Communication between ephrinB2 and EphB4 within the osteoblast lineage显示文摘 | Martin TJ Allan EH Ho PW | | 0，，01： | 1 |
| 4 | Overt propositional speech in chronic nonfluent aphasia studied with the dynamic susceptibility contrast fMRI method显示文摘 | Martin PI Baker EH | 2004 | Neuroimage2004，22，： | 1 |
| 5 | Regulation of MMP-I and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions显示文摘 | Sun JX Martin EH | 2001 | Cancer Res2001，61，5： | 1 |
| 6 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 7 | Antibacterial activity of 9(S)-erythromycylamine-aldehyde condensation products显示文摘 | Kitchell BS Martin LD | 1974 | J Med Chem1974，17，1： | 1 |
| 8 | Overt propositional speech in chronic nonfluent aphasia studied with the dynamic susceptibility contrast fMRI method 显示文摘 | Naeser MA Martin PI Baker EH | 2004 | Neuroimage2004，22，1： | 1 |
| 9 | Preparation and anti microbial activity of gelatin microparticles containing propo显示文摘 | Bruschi ML Lara EH Martins CH | 2006 | Drug Devlnd Pharm2006，32，2： | 1 |
| 10 | Transmemberane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specificβ1 integrins显示文摘 | Zhang XA Alex LB Martin EH | 2001 | J Biol Chem2001，276，25： | 1 |
| 11 | Characteristics of coronary smooth muscle cells and adventitial fibroblasts显示文摘 | Patel S Shi Y Niculescu R Chung EH Martin JL Zalewski A | 2000 | Circulation2000，101，： | 1 |
| 12 | SNFing away at complex diseases: analysis of single - nucleotide polymorphisms around AFOE in Alzheimer disease显示文摘 | Martin ER Lai EH Gilbert JR | 2000 | Am J Hum Genet2000，67，： | 1 |
| 13 | Erlotinib in previously treated non-small cell lung cancer显示文摘 | Shepherd FA Rodrigues Pereira J Ciuleanu T Tan EH Hirsh V Thongprasert S Campos D Maoleekoonpiroj S Smylie M Martins R van Kooten M Dediu M Findlay B Tu D Johnston D Bezjak A Clark G Santabárbara P Seymour L National Cancer Institute of Canada Clinical T | | 0，，02： | 1 |
| 14 | Overt propositional speech in chronic nonfluent aphasia studied with the dynamic susceptibility contrast fMRI method显示文摘 | Naeser MA Martin PI Baker EH | 2004 | NeuroImage2004，22，1： | 1 |
| 15 | Regulation of MMP-I and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions显示文摘 | Jianxin S Martin EH | 2001 | Cancer Res2001，61，： | 1 |
| 16 | Characteristics of coronary smooth muscle cells and adventitial fibroblasts显示文摘 | Patel S Shi Y Niculescu R Chung EH Martin JL Zalewki A | 2000 | Circulation2000，101，5： | 1 |
| 17 | SNPing away at complexdiseases : analysis of single-nucleotide polymorphisms around APOEin Alzheimer disease 显示文摘 | Martin ER Lai EH Gilbert J R | 2000 | Am J Hum Genet2000，67，2： | 1 |
| 18 | Overt propositional speech in chronic nonfluent aphasia studied with the dynamic susceptibility contrast fMRI method显示文摘 | Naeser MA Martin PI Baker EH | 2004 | Neuroimage2004，22，： | 1 |
| 19 | Laboratory diagnosis of Ebola virus disease 显示文摘 | Martin P Laupland KB Frost EH | 2015 | Intensive Care Med2015，41，5： | 1 |
| 20 | SNPing away at complex diseases:analysis of singlenucleotide polymorphisms around APOE in Alzheimer disease 显示文摘 | Martin ER Lai EH Gilbert JR | 2000 | Am J Hum Genet2000，67，2： | 1 |
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