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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | Bevacizumab (Avastin) eye drops inhibit corneal neovascularization显示文摘 | Felix Bock Yanyan K?nig Friedrich Kruse Martin Baier Claus Cursiefen | 2008 | Graefe’s Archive for Clinical and Experimental Ophthalmology2008，，2： | 2 |
| 3 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 4 | Lipocalin-2 Is a Disease Activity Marker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and TNF-α and Modulated by IL23R Genotype Status显示文摘 | Johannes Stallhofer Matthias Friedrich Astrid Konrad-Zerna Martin Wetzke Peter Lohse Jürgen Glas Cornelia Tillack-Schreiber Fabian Schnitzler Florian Beigel Stephan Brand | 2015 | Inflammatory Bowel Diseases2015，，10： | 2 |
| 5 | Surgical atrial septal defect closure after interventional occluder placement: Incidence and outcome显示文摘 | Thomas Walther Christian Binner Ardawan Rastan Ingo D?hnert Nicolas Doll Volkmar Falk Friedrich W. Mohr Martin Kostelka | 2007 | The Journal of Thoracic and Cardiovascular Surgery2007，，3： | 1 |
| 6 | A neural network- based ionospheric model for the auroral zone 显示文摘 | Lee-Anne McKinnell Martin Friedrich | 2007 | Journal of Atmospheric and Solar-Terrestrial Physics2007，69，14： | 1 |
| 7 | MPC of Switching in a Boost Converter Using a Hybrid State Model With a Sliding Mode Observer显示文摘 | Friedrich Martin Oettmeier Jason Neely Steve Pekarek | 2009 | IEEE Trans- actions On Industrial Electronics2009，56，9： | 1 |
| 8 | Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia显示文摘 | Brigitte Mohr Johannes Schetelig Kerstin Sch?fer‐Eckart Norbert Schmitz Mathias H?nel Wolf R?sler Norbert Frickhofen Hartmut Link Andreas Neubauer Ulrich Schuler Uwe Platzbecker Jan M. Middeke Gerhard Ehninger Martin Bornh?user Markus Schaich Friedrich St | 2013 | Br J Haematol2013，，： | 1 |
| 9 | Siegmund,et al,Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma显示文摘 | Martin G Friedrich Shahin Chandrasoma Kimberly D | 2005 | Eur J Cancer2005，41，17： | 1 |
| 10 | A Stiglerian View on Banking Supervision显示文摘 | HEINEMANN FRIEDRICH MARTIN SCHULER | 2004 | Public Choice2004，121，1： | 1 |
| 11 | PillCamColon2 after incomplete colonoscopy-A prospective multicenter study显示文摘AIM To evaluate the ability of PillCamColon2 to visualize colonic segments missed by incomplete optical colonoscopy(OC) and to assess the diagnostic yield.METHODS This prospective multicentre study included 81 patients from nine centres who underwent second-generation colon capsule endoscopy(CCE) following incomplete OC performed by an experienced gastroenterologist(> 1000 colonoscopies). Patients with stenosis were excluded. According to patient preferences, CCE was performed the following day(protocol A) after staying on clear liquids and 0.75 L Moviprep in the morning or within 30 d after new split-dose Moviprep(protocol B). Boosts consisted of 0.75 L and 0.25 L Moviprep, and phospho-soda was given as a rescue if the capsule was not excreted after seven hours.RESULTS Seventy-four patients were analysed(51% of them in group A; 49% in group B). Bowel cleansing was adequate in 67% of cases, and CCE could visualize colonic segments missed by incomplete colonoscopy in 90% of patients under protocol A and 97% of patients under protocol B(P = 0.35, n.s.). Significant polyps including adenocarcinoma were detected in 24% of cases. Detection rates for all polyps and significant polyps per patient were similar in both protocols. Polyps were found predominantly in the right colon(86%) in segments that were not reached by OC. Extracolonic findings-such as reflux esophagitis, suspected Barrett esophagus, upper GI-bleeding, gastric polyps, gastric erosions and angiectasia-were detected in eight patients. Pill Cam Colon2 capsule was retained in the ileum of one patient(1.4%) without symptoms and removed during an uneventful resection for unknown Crohn's disease that was diagnosed as the cause of anemia, which was the indication for colonoscopy. CCE was well tolerated. One patient suffered from selflimiting vomiting after consuming the phospho-soda.CONCLUSION Second-generation CCE using a low-volume preparation is useful after incomplete OC, and it allows for the detection of additional relevant findings, but cleansing efficiency could be improved. | Peter Baltes Marc Bota Jorg Albert Michael Philipper Hans-Georg Horster Friedrich Hagenmüller Ingo Steinbrück Ralf Jakobs Matthias Bechtler Dirk Hartmann Horst Neuhaus Jean-Pierre Charton Rupert Mayershofer Horst Hohn Thomas Rosch Stefan Groth Tanja Nowak Peter Wohlmuth Martin Keuchel | 2018 | World Journal of Gastroenterology2018，24，31： | 1 |
| 12 | Investigations on the Flow Field in an Unshrouded Pump Impeller Geometry显示文摘Transient CFD simulations are performed to investigate the flow behaviour inside an unshrouded pump using the SAS method. Two blade designs are compared at two different tip clearances and the results are validated by measurements. The detected vortex structure is visualized by the normalized helicity, further discussed regarding its development and behaviour and finally implicated to the efficiency of the two different blade designs. | Sten Sieber Friedrich Frhlig Saban Caglar Martin Gabi | 2012 | Journal of Thermal Science2012，21，2： | 1 |
| 13 | Accelerated cathodic reaction in microbial corrosion of iron due to direct electron uptake by sulfate-reducing bacteria显示文摘 | Hendrik Venzlaff Dennis Enning Jayendran Srinivasan Karl J.J. Mayrhofer Achim Walter Hassel Friedrich Widdel Martin Stratmann | 2013 | Corrosion Science2013，，： | 1 |
| 14 | Inflammatory Markers at the Site of Ruptured Plaque in Acute Myocardial Infarction: Locally Increased Interleukin-6 and Serum Amyloid A but Decreased C-Reactive Protein显示文摘 | Willibald Maier Lukas A. Altwegg Roberto Corti Steffen Gay Martin Hersberger Friedrich E. Maly Gabor Sütsch Marco Roffi Michel Neidhart Franz R. Eberli Felix C. Tanner Sharon Gobbi Arnold von Eckardstein Thomas F. Lüscher | 2005 | Circulation2005，，11： | 1 |
| 15 | Minimally invasive mitral valve surgery is a very safe procedure with very low rates of conversion to full sternotomy ? 显示文摘 | Marcel Vollroth Joerg Seeburger Jens Garbade Bettina Pfannmueller David Holzhey Martin Misfeld Michael A. Borger Friedrich W. Mohr | 2012 | European Journal of Cardio-Thoracic Surgery2012，，1： | 1 |
| 16 | S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke 显示文摘 | Ulrich Missler Martin Wiesmann Christine Friedrich | 1997 | Stroke1997，28，10： | 1 |
| 17 | Gastric adenocarcinoma: pathomorphology and molecular pathology显示文摘 | Martin Werner Karl Friedrich Becker Gisela Keller Heinz H?fler | 2001 | Journal of Cancer Research and Clinical Oncology2001，，4： | 1 |
| 18 | Toll-like receptor 4 gene polymorphism modulates phenotypic expression in patients with hereditary hemochromatosis显示文摘 | Pierre-Alexandre Krayenbuehl Martin Hersberger Kaspar Truninger Beat Müllhaupt Friedrich E. Maly Mario Bargetzi Georg Schulthess | 2010 | European Journal of Gastroenterology & Hepatology2010，，7： | 1 |
| 19 | Surgery for Gastrointestinal Stromal Tumors of the Stomach显示文摘 | Gerd R. Silberhumer Martin Hufschmid Fritz Wrba Georg Gyoeri Sebastian Schoppmann Barbara Tribl Etienne Wenzl Gerhard Prager Friedrich Laengle Johannes Zacherl | 2009 | Journal of Gastrointestinal Surgery2009，，7： | 1 |
| 20 | Accelerated cathodic reaction in microbial corrosion of iron due to direct electron uptake by sulfate-reducing bacteria显示文摘 | Hendrik Venzlaff Dennis Enning Jayendran Srinivasan Karl J.J. Mayrhofer Achim Walter Hassel Friedrich Widdel Martin Stratmann | 2013 | Corrosion Science2013，，： | 1 |
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