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47篇 您的检索式：作者名="Martiniuk"

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	题名	作者	年代	出处	被引量
1	Protective effects of anti-ricin A-chain RNA aptamer against ricin toxicity显示文摘AIM: To investigate the therapeutic potential of an RNA ligand (aptamer) specific for the catalytic ricin A-chain (RTA), the protective effects of a 31-nucleo-tide RNA aptamer (31RA), which formed a high affi nity complex with RTA, against ricin-induced toxicity in cellbased luciferase translation and cell cytotoxicity assays were evaluated. METHODS: To test the therapeutic potential of anti-RTA aptamers in Chinese hamster ovary (CHO) AA8 cells stably transfected with a tetracycline regulat-able promoter, ricin ribotoxicity was measured using luciferase and ricin-induced cytotoxicity was ascertained by MTS cell proliferation assay with tetrazolium compound [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium]. RESULTS: Inhibition of protein synthesis by ricin in CHO AA8 cells resulted in diminished luciferase activity and treatment with polyclonal antibody against degly-cosylated RTA (dgA) neutralized the inhibitory effects of ricin on luciferase activity and protected against ricin-induced cytotoxicity as measured by MTS assay. The 31RA anti-RTA aptamer inhibited the translation of luciferase mRNA in cell-free reticulocyte translation as- say. 31RA aptamer also partially neutralized the inhibitory effects of ricin on luciferase activity and partially protected against ricin-induced cytotoxicity in CHO AA8 cells. CONCLUSION: We have shown that anti-RTA RNA aptamer can protect against ricin ribotoxicity in cellbased luciferase and cell cytotoxicity assays. Hence, RNA aptamer that inhibits RTA enzymatic activity represents a novel class of nucleic acid inhibitor that has the potential to be developed as a therapeutic agent for the treatment of ricin intoxication.	Shaoan Fan Feng Wu Frank Martiniuk Martha L Hale Andrew D Ellington Kam-Meng Tchou-Wong	2008	World Journal of Gastroenterology2008，14，41：	3
2	Problem-based learning (PBL) and public health: an initial exploration of perceptions of PBL in Vietnam 显示文摘	Grisham JW Martiniuk AL Negin J	2015	Asia Pac J Public Health2015，27，2：	1
3	Apoptotic gene expression in Alzheimer's disease hippocampal tissue显示文摘	SAJAN FD MARTINIUK F MARCUS DL	2007	Am J Alzheimers Dis Other Demen2007，22，4：	1
4	Hypertension:its prevalence and population attributable fraction for mortality from cardiovascular disease in the Asia Pacifc Region显示文摘	MARTINIUK A L LEE C M LAWES C M	2007	American Journal of Hypertension2007，25，1：	1
5	Sex differences in carotid plague and stenosis显示文摘	Iemolo F Martiniuk A Steinman DA		0，，02：	1
6	Collision Tumor of Primary Laryngeal Mucosal Melanoma and Invasive Squamous Cell Carcinoma with IL-17A and CD70 Gene Over-Expression显示文摘	Sasis Sirikanjanapong Biana Lanson Milan Amin Frank Martiniuk Hideko Kamino Beverly Y. Wang	2010	Head and Neck Pathology2010，，4：	1
7	Carrier frequency for glycogen storage disease type Ⅱ in New York and estimates of affected individuals born with the disease显示文摘	Martiniuk F Chen A Mack A	1998	Am J Med Genet1998，79，：	1
8	Hypertension : its preva- lence and population-attributable fraction for mortality from cardio- vascular disease in the Asia-Pacific region显示文摘	Martiniuk AL Lee CM Lawes CM	2007	J Hypertens2007，25，1：	1
9	Apoptotic gene expression in Alzheimer's disease hippocampal tissue显示文摘	Sajan FD Martiniuk F Marcus DL	2007	Am J Alzheimers Dis Other Demen2007，22，4：	1
10	Sex differences in carotid plaque and stenosis显示文摘	Iemolo F Martiniuk A Steinman DA	2004	Stroke2004，35，：	1
11	Sex Differences in Carotid Plaque and Stenosis显示文摘	Francesco Iemolo Alexandra Martiniuk David A. Steinman J. David Spence	2004	Stroke: Journal of the American Heart Association2004，，2：	1
12	Carrier frequency for glycogen storage disease type II in New York and estimates of affected individuals born with the disease显示文摘	Martiniuk F Chen A Mack A	1998	Am J Med Genet1998，79，：	1
13	Differences in plaque and stenosis显示文摘	Iemolo F Martiniuk A Steinman DA	2004	Stroke2004，35，2：	1
14	A model of mRNA splicing in adult lysosomal storage disease (glycogenosis type II)显示文摘	Raben N Nichols RC Martiniuk F	1996	Hum Mol Genet1996，5，：	1
15	The influence of design and definition on the proportion of general epilepsy cohorts with remission and intractability显示文摘	Abimbola S Martiniuk AL Hackett ML	2011	Neuroepidemiology2011，36，：	1
16	Sydney epi- lepsy incidence study to measure illness consequences: the SESIMIC observational epilepsy study protocol 显示文摘	Hackett M L Glozier N S Martiniuk A L	2011	BMC Neurol2011，11，3：	1
17	Sex differences in carotid plaque and stenosis显示文摘	Iemolo F Martiniuk A Steinman DA	2004	Stroke2004，3，5：	1
18	Sex differences in carotid plaque and stenosis显示文摘	Iemolo F Martiniuk A Steinman DA	2004	Stroke2004，35，2：	1
19	Neutralizing VEGF decreas-es tortuosity and alters endothelial cell division orientation in arteriolesand veins in a rat model of ROP : relevance to plus disease 显示文摘	Hartnett ME Martiniuk D Byfield G	2008	InvestOphthalmol Vis Sci2008，48，7：	1
20	Expression of CD70 and the TH17 transcription factor RORgammaT in human contact dermatitis显示文摘	Martiniuk F Lee DS Gaspari A	2008	J Drugs Dermatol2008，7，10：	1

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