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| 1 | Hepatitis C virus infection and thyroid autoimmunedisorders:A model of interactions between the host and theenvironment显示文摘The hepatitis C virus(HCV) infection is an important public health problem and it is associated with hepatic and extrahepatic manifestations. Autoimmune thyroid diseases are common in HCV infected patients and the standard interferon-based treatment is associated with an increase of the immune-mediated thyroid damage. Recent evidence in the literature analyzed critical points of the mechanisms of thyroid damage, focusing on the balance between the two sides of the interaction: The environment(virus infection with potential crossreaction) and the host(susceptibility genes with consistent immune response). The spectrum of antiviral treatment for chronic HCV infection is rapidly expanding for the development of dual o triple therapy. The availability of interferon-free combined treatment with direct antiviral agents for HCV is very promising, in order to ameliorate the patient compliance and to reduce the development of thyroid autoimmunity. | francesca pastore antonio martocchia manuela stefanelli pietro prunas stefania giordano lavinia toussan antonio devito paolo falaschi | 2016 | World Journal of Hepatology2016，8，2： | 12 |
| 2 | The burden of comorbidity and the C-reactive protein levels in nonthy- roidal illness syndrome with metabolic syndrome and atherosclerosis-related cardiovascular complications 显示文摘 | MARTOCCHIA A COLA S FRUGONI P | 2010 | Ann N Y Acad Sci2010，1193，： | 1 |
| 3 | The burden of comorbidityand the C-reactive protein levels in nonthyroidal illness syndrome withmetabolic syndrome and atherosclerosis-related cardiovascularcomplications显示文摘 | Martocchia A Cola S Frugoni P | 2010 | Ann N Y Acad Sci2010，1193，： | 1 |
| 4 | Asso- ciation between human leukocyte antigen (HLA) and in- terferon-induced thyroid diseases in four patients with HCV-related chronic hepatitis 显示文摘 | Labbadia G Martocchia A Mammarella A | 2005 | Neuro Endocrinol Lett2005，26，2： | 1 |
| 5 | The burden of comorbidity and the C-reactive protein levels in nonthyroidal illness syndrome with metabolic syndrome and atherosclerosis-related cardiovascular complications显示文摘 | Martocchia A Cola S Frugoni P | 2010 | Ann N Y Acad Sci2010，1193，： | 1 |
| 6 | Increased serum concentration of nerve growth factor in patients with microprolactinoma 显示文摘 | SigMa S Martocchia A Missale C | 2004 | Neuropeptides2004，38，1： | 1 |
| 7 | Thyrotoxicosis,unstable angina and normal coronary angiogram显示文摘 | Morelli S Gurgo AM Martocchia A | 1999 | G Ital Cardiol1999，29，11： | 1 |
| 8 | Association of diffuse liver glycogenosis and mild focal macrovesicular steatosis in a patient with poorly controlled type 1 diabetes显示文摘 | A. Martocchia M. G. Risicato C. Mattioli M. Antonelli L. Ruco P. Falaschi | 2008 | Internal and Emergency Medicine2008，，3： | 1 |
| 9 | The burden of comorbidity and the C-reactive protein levels in nonthyroidal illness syndrome with metabolic syndrome and atherosclerosis-related cardiovascular complications显示文摘 | Martocchia A Cola S Frugoni P | 2010 | Ann N Y Acad Sci2010，1193，1： | 1 |
| 10 | Diagnosis of hepatic glycogenosis in poorly controlled type 1 diabetes mellitus显示文摘Hepatic glycogenosis(HG) in type 1 diabetes is a underrecognized complication. Mauriac firstly described the syndrome characterized by hepatomegaly with altered liver enzymes, growth impairment, delay puberty and Cushingoid features, during childhood. HG in adulthood is characterized by the liver disorder(with circulating aminotransferase increase) in the presence of poor glycemic control(elevation of glycated hemoglobin, Hb A1 c levels). The advances in the comprehension of the metabolic pathways driving to the hepatic glycogen deposition point out the role of glucose transporters and insulin mediated activations of glucokinase and glycogen synthase, with inhibition of glucose-6-phosphatase. The differential diagnosis of HG consists in the exclusion of causes of liver damage(infectious, metabolic, obstructive and autoimmune disease). The imaging study(ultrasonography and/or radiological examinations) gives information about the liver alterations(hepatomegaly), but the diagnosis needs to be confirmed by the liver biopsy. The main treatment of HG is the amelioration of glycemic control that is usu-ally accompanied by the reversal of the liver disorder. In selected cases, more aggressive treatment options(transplantation) have been successfully reported. | Stefania Giordano Antonio Martocchia Lavinia Toussan Manuela Stefanelli Francesca Pastore Antonio Devito Marcello G Risicato Luigi Ruco Paolo Falaschi | 2014 | World Journal of Diabetes2014，5，6： | 1 |
| 11 | Association between human leukocyte antigen (HLA) and interferon-α induced thyroid diseases in four patients with HCV-related chronic hepatitis 显示文摘 | Labbadia G Martocchia A Mammarella A | 2005 | Neuro Endocrinol Lett2005，26，2： | 1 |
| 12 | The burden of comorbidity and the C-reactive protein levels in nonthyroidal illness syndrome with metabolic syndrome and atherosclerosis-related cardiovascular complications显示文摘 | Martocchia A Cola S Frugoni P | 2010 | Ann N Y Acad Sci2010，1193，： | 1 |
| 13 | The burden of comorbidity and the C-reactive protein levels in nonthyroidal illness syndrome with metabolic syndrome and atheroselerosis-related cardiovascular complications 显示文摘 | Martocchia A Cola S Fmgoni P | 2010 | Ann N YAcad Sci2010，1193，： | 1 |
| 14 | The burden of comorbidity and the C-reactive protein levels in nonthyroidal illness syndrome with metabolic syndrome and atherosclerosis-related cardiovascular complications显示文摘 | Martocchia A Cola S Frugoni P | | 0，，： | 1 |
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