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| 1 | Prostate cancer upgrading or downgrading of biopsy Gleason scores at radical prostatectomy:prediction of'regression to the mean'using routine clinical features with correlating biochemical relapse rates显示文摘Recommendations for managing clinically localized prostate cancer are structured around clinical risk criteria,with prostate biopsy(PB)Gleason score(GS)being the most important factor.Biopsy to radical prostatectomy(RP)specimen upgrading/downgrading is welldescribed,and is often the ratio nale for costly imaging or genomic studies.We prese nt simple,no-cost an a lyses of clinical parametersto predict which GS 6 and GS 8 patients will change to GS 7 at prostatectomy.From May 2006 to December 2012,1590 patientsunderwent robot-assisted radical prostatectomy(RARP).After exclusions,we identified a GS 6 cohort of 374 patients and a GS 8cohort of 91 patients.During this era,>1000 additional patients were enrolled in an active surveillanee(AS)program.For GS 6,265(70.9%)of 374 patients were upgraded,and the cohort included 183(48.9%)patients eligible for AS by the Prostate Cancer ResearchInternational Active Surveillance Study(PRIAS)standards,of which 57.9%were upgraded.PB features that predicted a>90%chanceof upgrading included≥7 cores positive,maximum foci length≥8 mm in any core,and total tumor involvement≥30%.For GS 8,downgrading occurred in 46(50.5%),which was significantly higher for single core versus multiple cores(80.4%vs 19.6%,P=0.011).Biochemical recurre nee(BCR)occurred in 3.4%of GS 6 upgraded versus 0%non upgraded,and in GS 8,19.6%downgraded versus42.2%nondown graded.In coun seling men with clin ically localized prostate can cer,the odds of GS cha nge should be presented,andcertain men with high-volume GS 6 or low-volume GS 8 can be counseled with GS 7-based recommendations. | Muammer Altok Patricia Troncoso Mary F Achim Surena F Matin Graciela N Gonzalez John W Davis | 2019 | Asian Journal of Andrology2019，21，6： | 4 |
| 2 | Cell:癌基因“遗传平衡”或会影响患者对癌症疗法的反应显示文摘进行癌症疗法的选择越来越需要确定肿瘤细胞中是否含有一些特殊突变的癌基因会驱动癌细胞异常生长。并且确定是否癌细胞会对特殊药物耐受或敏感.近日来自加州大学旧金山分校的研究人员就通过研究发现。以常见的癌基因KRAs突变为例。患者对疗法的反应往往会随着肿瘤的不断进化而发生改变。相关研究刊登于国际杂志Cell上。 | Michael R. Burgess Eugene Hwang Rana Mroue Craig M. Bielski Anica M. Wandler Benjamin J. Huang Ari J. Firestone Amy Young Jennifer A. Lacap Lisa Crocker Saurabh Asthana Elizabeth M. Davis Jin Xu Keiko Akagi Michelle M. Le Beau Qing Li Benjamin Haley David Stokoe Deepak Sampath Barry S. Taylor Marie Evangelista Kevin Shannon | 2017 | 现代生物医学进展2017，17，18： | 2 |
| 3 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 4 | Hydrogenolysis of glycerol over carbon-supported Ru and Pt catalysts显示文摘 | Erin P. Maris Robert J. Davis | 2007 | Journal of Catalysis2007，，2： | 2 |
| 5 | In - situ X - ray ab- sorption spectroscopy of supported ru catalysts in the a- queous phase显示文摘 | Ketchie W C Maris E P Davis R J | 2007 | Chem Mater2007，19，： | 1 |
| 6 | Evidence for the Effectiveness of CME- A Review of 50 Randomized Controlled Trials显示文摘 | David A Davis Mary Ann Thomson Andrew D Oxman | 1992 | JAMA1992，268，9： | 1 |
| 7 | Hydrogenolysis of glycerol over carbon-supported Ru and Pt catalysts 显示文摘 | Maris E P Davis R J | 2007 | J Catal2007，249，2： | 1 |
| 8 | Hydrogenolysis of glycerol over carbon-supported Ru and Pt catalysts 显示文摘 | Maris E P Davis R J | 2007 | Journal of Catalysis2007，249，2： | 1 |
| 9 | The effect of aromatherapy massage with music on the stress and anxiety levels of emergency nurses显示文摘 | Cathy Davis Marie Cooke Kerri Holzhauser | 2005 | Austr Emerg Nurs J2005，8，5： | 1 |
| 10 | Hydrogenolysis of glycerol over carbon-supported Ru and Pt catalysts 显示文摘 | Maris E P Davis R J | 2007 | Journal of Catalysis2007，249，： | 1 |
| 11 | Kidney Transplantation Alone in ESRD Patients With Hepatitis C Cirrhosis显示文摘 | Anil S. Paramesh John Y. Davis Chaitanya Mallikarjun Rubin Zhang Robert Cannon Nathan Shores Mary T. Killackey Jennifer McGee Bob H. Saggi Douglas P. Slakey Luis Balart Joseph F. Buell | 2012 | Transplantation Journal2012，，3： | 1 |
| 12 | Hydrogenolysis of glycerol over carbon-supported Ru and Pt catalysts显示文摘 | Maris E P Davis R J | 2007 | J Catal2007，249，2： | 1 |
| 13 | Reduced thalamic volumes in major depressive disorder显示文摘 | Allison Carol Nugent Rebecca Marie Davis Carlos Alberto Zarate Wayne Curtis Drevets | 2013 | Psychiatry Research: Neuroimaging2013，，3： | 1 |
| 14 | Hydrogenolysis of glycerol over carbon-supported Ru and Pt catalysts显示文摘 | Davis R J Maris E P | 2007 | J Catal2007，249，2： | 1 |
| 15 | Modulation of angiogenesis by thyroid hormone and hormone analogues: implications for cancer management显示文摘 | Shaker A. Mousa Hung-Yun Lin Heng Yuan Tang Aleck Hercbergs Mary K. Luidens Paul J. Davis | 2014 | Angiogenesis2014，，： | 1 |
| 16 | Recurrence of Differentiated Thyroid Carcinoma During Full TSH Suppression: Is the Tumor Now Thyroid Hormone Dependent?显示文摘 | Paul J. Davis Aleck Hercbergs Mary K. Luidens Hung-Yun Lin | 2015 | Hormones and Cancer2015，，： | 1 |
| 17 | Development of a data collection and management system in West Africa:challenges and sustainability显示文摘Background:Developing and sustaining a data collection and management system(DCMS)is difficult in malariaendemic countries because of limitations in internet bandwidth,computer resources and numbers of trained personnel.The premise of this paper is that development of a DCMS in West Africa was a critically important outcome of the West African International Centers of Excellence for Malaria Research.The purposes of this paper are to make that information available to other investigators and to encourage the linkage of DCMSs to international research and Ministry of Health data systems and repositories.Methods:We designed and implemented a DCMS to link study sites in Mali,Senegal and The Gambia.This system was based on case report forms for epidemiologic,entomologic,clinical and laboratory aspects of plasmodial infection and malarial disease for a longitudinal cohort study and included on-site training for Principal Investigators and Data Managers.Based on this experience,we propose guidelines for the design and sustainability of DCMSs in environments with limited resources and personnel.Results:From 2012 to 2017,we performed biannual thick smear surveys for plasmodial infection,mosquito collections for anopheline biting rates and sporozoite rates and year-round passive case detection for malarial disease in four longitudinal cohorts with 7708 individuals and 918 households in Senegal,The Gambia and Mali.Major challenges included the development of uniform definitions and reporting,assessment of data entry error rates,unstable and limited internet access and software and technology maintenance.Strengths included entomologic collections linked to longitudinal cohort studies,on-site data centres and a cloud-based data repository.Conclusions:At a time when research on diseases of poverty in low and middle-income countries is a global priority,the resources available to ensure accurate data collection and the electronic availability of those data remain severely limited.Based on our experience,we suggest the development of a regional DCMS.This approach is more economical than separate data centres and has the potential to improve data quality by encouraging shared case definitions,data validation strategies and analytic approaches including the molecular analysis of treatment successes and failures. | Jeffrey G.Shaffer Seydou O.Doumbia Daouda Ndiaye Ayouba Diarra Jules F.Gomis Davis Nwakanma Ismaela Abubakar Abdullahi Ahmad Muna Affara Mary Lukowski Clarissa Valim James C.Welty Frances J.Mather Joseph Keating Donald J.Krogstad | 2018 | Infectious Diseases of Poverty2018，7，1： | 1 |
| 18 | Biodegradation of three cellulosic fabrics in soil显示文摘 | MARY Warnock KAARON Davis DUANE Wolf | 2009 | AAES Research Series2009，582，： | 1 |
| 19 | Field-emission studies of boron-doped CVD diamond films following surface treatments显示文摘 | Mary S Davis T J | 1997 | Diamond and Related Materials1997，，6： | 1 |
| 20 | Hydrogenolysis of glycerol over carbon-supported Ru and Pt catalysts 显示文摘 | Maris E P Davis R J | 2007 | J Catal2007，249，2： | 1 |
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