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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet2005，，9503： | 2 |
| 3 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet . 2005 (9503)2005，，9503： | 2 |
| 4 | COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease显示文摘 | Wayne A Ray C Michael Stein James R Daugherty Kathi Hall Patrick G Arbogast Marie R Griffin | 2002 | The Lancet2002，，9339： | 1 |
| 5 | A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation显示文摘 | John C. Murray James A. Burch Robert D. Streilein Mary Ann Iannacchione Russell P. Hall Sheldon R. Pinnell | 2008 | Journal of the American Academy of Dermatology2008，，3： | 1 |
| 6 | Obesity,metabolic syndrome and dia- betic nephropathy显示文摘 | Marie C Hall JE | 2011 | Contrib Nephrol2011，170，： | 1 |
| 7 | Parainfluenza Virus Infection of Young Children: Estimates of the Population-Based Burden of Hospitalization显示文摘 | Geoffrey A. Weinberg Caroline B. Hall Marika K. Iwane Katherine A. Poehling Kathryn M. Edwards Marie R. Griffin Mary Allen Staat Aaron T. Curns Dean D. Erdman Peter G. Szilagyi | 2009 | The Journal of Pediatrics2009，，5： | 1 |
| 8 | The family relations, peer relations, and criminal activities of Caucasian and Hispanic-American gang members显示文摘 | Jean -Marie Lyon Scott Henggeler James A. Hall | 1992 | Journal of Abnormal Child Psychology1992，，5： | 1 |
| 9 | Small bowel angiodysplasia and novel disease associations: a cohort study显示文摘 | Grainne Holleran Barry Hall Mary Hussey Deirdre McNamara | 2013 | Scandinavian Journal of Gastroenterology2013，，4： | 1 |
| 10 | Compiler Research:The Next 50 Years显示文摘 | Mary Hall David Padu Keshav Pingali | 2009 | Communication of the ACM2009，52，2： | 1 |
| 11 | How to evaluation particles in manure显示文摘 | | 2004 | Western Dairy Sci2004，，3： | 1 |
| 12 | Working with non-NDF carbohydrates with manure evaluation and environmental considerations显示文摘 | | 2001 | J Anim Sci2001，，5： | 1 |
| 13 | A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation显示文摘 | John C. Murray James A. Burch Robert D. Streilein Mary Ann Iannacchione Russell P. Hall Sheldon R. Pinnell | 2008 | Journal of the American Academy of Dermatology2008，，3： | 1 |
| 14 | Workshop report: evaluation of genetic and epigenetic risks associated with assisted reproductive technologies and infertility显示文摘 | Rosanna Weksberg Cheryl Shuman Louise Wilkins-Haug Mellissa Mann Mary Croughan Donna Stewart Catherine Rakowsky Arthur Leader Judith Hall J.M. Friedman Joe Leigh Simpson Lewis Holmes Claire Infante-Rivard | 2007 | Fertility and Sterility2007，，1： | 1 |
| 15 | Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non–small cell lung carcinomas显示文摘 | Jennifer M. Boland Sibel Erdogan George Vasmatzis Ping Yang Lori S. Tillmans Michele R. Erickson Johnson Xiaoke Wang Lisa M. Peterson Kevin C. Halling Andre M. Oliveira Marie Christine Aubry Eunhee S. Yi | 2009 | Human Pathology2009，，8： | 1 |
| 16 | ADAM17 Controls Endochondral Ossification by Regulating Terminal Differentiation of Chondrocytes显示文摘 | Katherine C. Hall Daniel Hill Miguel Otero Darren A. Plumb Dara Froemel Cecilia L. Dragomir Thorsten Maretzky Adele Boskey Howard C. Crawford Licia Selleri Mary B. Goldring Carl P. Blobel | 2013 | Molecular and Cellular Biology2013，，16： | 1 |
| 17 | The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide显示文摘 | Cheryl Brantley-Finley Christopher S. Lyle Lihua Du Mary E. Goodwin Toria Hall Dominika Szwedo G.P. Kaushal Timothy C. Chambers | 2003 | Biochemical Pharmacology2003，，3： | 1 |
| 18 | A method for partitioning neutral detergent soluble carbohydrates显示文摘 | Mary B Hall William H Hoover Jocelyn P Jennings | 1999 | J Sci Food Agric1999，79，： | 1 |
| 19 | Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial–Cardiac Resynchronization Therapy (MADIT-CRT)显示文摘 | Wojciech Zareba Helmut Klein Iwona Cygankiewicz W. Jackson Hall Scott McNitt Mary Brown David Cannom James P. Daubert Michael Eldar Michael R. Gold Jeffrey J. Goldberger Ilan Goldenberg Edgar Lichstein Heinz Pitschner Mayer Rashtian Scott Solomon Sami Vis | 2011 | Circulation2011，，： | 1 |
| 20 | Reducing negative thinking and depressive symptom in college woman显示文摘 | Ann R Peden Lynne A Hall Mary Kay Rayens Lora L Beebe | 2000 | Journal of Nursing Scholarship2000，132，2： | 1 |
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