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| 1 | Displacement manifold method for type synthesis of lower-mobility parallel mechanisms显示文摘Type synthesis of lower-mobility parallel mechanisms is a hot and frontier topic in international academic and industrial field. Based on the Lie group theory, a displacement manifold synthesis method is proposed. For all the nine kinds of lower-mobility parallel mechanisms, the mechanism displacement manifold, limb displacement manifold and the geometrical conditions which guarantee that the intersection of the limb displacement manifold is the desired mechanism displacement manifold are enumerated. Various limb kinematic chains can be obtained using the product closure of displacement subgroup. Parallel mechanisms can be constructed with these limbs while obeying the geometrical conditions. Hence, all the nine kinds of lower-mobility parallel mechanisms can be synthesized using this method. Since displacement manifold deals with finite motion, the result mechanism of synthesis have full-cycle mobility. Novel architectures of lower-mobility parallel mechanisms can be obtained using this method. | LI Qinchuan HUANG Zhen Jacques Marie Hervé | 2004 | Science China(Technological Sciences)2004，47，6： | 28 |
| 2 | Allergen micro-array detection of specific IgE-reactivity in Chinese allergy patients显示文摘背景变应原微数组是为浆液 IgE-reactivity.In 屏蔽这学习变应原的强大的工具微数组被用来鉴别在选择中国过敏症 patients.Methods 之中统治IgE有约束力的变应原和跨反应的模式学习从广州的城市用耐心的 sera 被进行,南京,有 Dermatophagoides pteronyssinus ( Der p )的 Chengdu 和 Shenyang.In 总数 100 sera 比 50 kU/L 高的特定的IgE水平为对 103 | ZHENG Yi-wu LI Jing LAI Xu-xin ZHAO De-yu LIU Xiao-fan LIN Xiao-ping Birgitte Gjesing Paola Palazzo Adriano Mari ZHONG Nan-shan Michael D Spangfort | 2011 | Chinese Medical Journal2011，，24： | 16 |
| 3 | Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-β-susceptible hepatocellular carcinoma cells显示文摘AIM:To investigate the role of transforming growth factor(TGF)-β-inducible early gene 1(TIEG1) in TGF-β-induced growth inhibition in hepatocellular carcinoma(HCC) cells.METHODS:Human hepatocyte and HCC cell lines with varied susceptibilities to TGF-β1 were tested by methylthiazoletetrazolium(MTT) assay.The expression changes of Smad2,Smad3,Smad4,Smad7,TIEG1 and TIEG2 gene following treatment with TGF-β1 in a TGF-β-sensitive hepatocyte cell line(MIHA),a TGF-β-sensitive hepatoma cell line(Hep3B) and two TGF-β-insensitive hepatoma cell lines(HepG2 and Bel7404) were examined.SiRNA targeting TIEG1 was transfected into Hep3B cells and the sensitivity of cells to TGF-β1 was examined.Overexpression of TIEG1 was induced by lentiviral-mediated transduction in TGF-β1-resistant hepatoma cell lines(Bel7404 and HepG2).MTT assay and 4',6-Diamidino-2-phenylindole staining were used to identify cell viability and apoptosis,respectively.The expression level of stathmin was measured by reverse transcriptase polymerase chain reaction and Western-blotting analysis,and stathmin promoter activity by TIEG1 was monitored by a luciferase reporter gene system.RESULTS:TIEG1 was significantly upregulated by TGF-β1 in the TGF-β1-sensitive HCC cell line,Hep3B,but not in the resistant cell lines.The suppression of TIEG1 by siRNAs decreased the sensitivity of Hep3B cells to TGF-β1,whereas the overexpression of TIEG1 mediated growth inhibition and apoptosis in TGF-β1-resistant HCC cell lines,which resembled those of TGF-β1-sensitive HCC cells treated with TGF-β1.Our data further suggested that stathmin was a direct target of TIEG1,as stathmin was signif icantly downregulated by TIEG1 overexpression,and stathmin promoter activity was inhibited by TIEG1 in a dose-dependent manner.CONCLUSION:Our data suggest that transactivation of TIEG1 conferred growth inhibition of TGF-β-susceptible human HCC cells. | Lei Jiang Yiu-Kay Lai Jin-Fang Zhang Chu-Yan Chan Gang Lu Marie CM Lin Ming-Liang He Ji-Cheng Li Hsiang-Fu Kung | 2012 | World Journal of Gastroenterology2012，18，17： | 13 |
| 4 | Heme oxygenase-1 system and gastrointestinal inflammation:A short review显示文摘Heme oxygenase-1(HO-1) system catalyzes heme to biologically active products:carbon monoxide,biliverdin/bilirubin and free iron.It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes.A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract.This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date.The ability to upregulate HO-1 by pharmacological means or using gene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. | Xiao Zhu Wen-Guo Fan Dong-Pei Li Hsiangfu Kung Marie CM Lin | 2011 | World Journal of Gastroenterology2011，17，38： | 9 |
| 5 | RNA-binding proteins in neurological diseases显示文摘Emerging studies support that RNA-binding proteins(RBPs)play critical roles in human biology and pathogenesis.RBPs are essential players in RNA processing and metabolism,including pre-mRNA splicing,polyadenylation,transport,surveillance,mRNA localization,mRNA stability control,translational control and editing of various types of RNAs.Aberrant expression of and mutations in RBP genes affect various steps of RNA processing,altering target gene function.RBPs have been associated with various diseases,including neurological diseases.Here,we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2,HuR/HuB/HuC/HuD,TDP-43,Fus,Rbfox1/Rbfox2,QKI and FMRP,discussing their function and roles in human diseases. | ZHOU HuaLin MANGELSDORF Marie LIU JiangHong ZHU Li WU Jane Y | 2014 | Science China(Life Sciences)2014，57，4： | 9 |
| 6 | Conversion of confined metal@ZIF-8 structures to intermetallic nanoparticles supported on nitrogen-doped carbon for electrocatalysis显示文摘 | Zhiyuan Qi Yuchen Pei Tian Wei Goh Zhaoyi Wang Xinle Li Mary Lowe Raghu V. Maligal-Ganesh Wenyu Huang | 2018 | Nano Research2018，11，6： | 6 |
| 7 | APP physiological and pathophysiological functions: insights from animal models显示文摘淀粉的先锋蛋白质(应用软件) 在最近的年里的集中的学习下面,主要由于它在 Alzheimer 的疾病(广告) 的致病的关键角色。β淀粉(Aβ) 从应用软件解朊的劈开产生的肽能聚集,在人的广告大脑导致匾形成。削尖影响 Aβ 的应用软件的变化;生产被发现为世袭早发作原因家庭广告。它是很可能的那阐明应用软件的生理的性质将极大地在广告致病便于它的角色的理解。很多个应用软件 loss-of-function 和 gain-of-function 模型包括 Caenorhabditis elegans,果蝇, zebrafish 和老鼠在模型有机体被建立了。这些在 vivo 模型提供我们珍贵卓见进应用软件生理的函数。另外,几只敲门在里面老鼠当模特儿在生理的水平表示变异的应用软件是可得到的允许我们没有应用软件 overexpression,学习广告致病。这篇文章将考察生理的水流和应用软件的 pathophysiological 动物模型。 | Qinxi Guo Zilai Wang Hongmei Li Mary Wiese Hui Zheng | 2012 | Cell Research2012，22，1： | 5 |
| 8 | Inferring the Tree of Life of the order Cypriniformes, the earth's most diverse clade of freshwater fishes: Implications of varied taxon and character sampling显示文摘The phylogenetic relationships of species are fundamental to any biological investigation, including all evolutionary studies. Accurate inferences of sister group relationships provide the researcher with an historical framework within which the attributes or geographic origin of species (or supraspecific groups) evolved. Taken out of this phylogenetic context, interpretations of evolutionary processes or origins, geographic distributions, or speciation rates and mechanisms, are subject to nothing less than a biological experiment without controls. Cypriniformes is the most diverse clade of freshwater fishes with estimates of diversity of nearly 3,500 species. These fishes display an amazing array of morphological, ecological, behavioral, and geographic diversity and offer a tremendous opportunity to enhance our understanding of the biotic and abiotic factors associated with diversification and adaptation to environments. Given the nearly global distribution of these fishes, they serve as an important model group for a plethora of biological investigations, including indicator species for future cli-matic changes. The occurrence of the zebrafish, Danio rerio, in this order makes this clade a critical component in understanding and predicting the relationship between mutagenesis and phenotypic expressions in vertebrates, including humans. With the tremendous diversity in Cypriniformes, our understanding of their phylogenetic relationships has not proceeded at an acceptable rate, despite a plethora of morphological and more recent mo-lecular studies. Most studies are pre-Hennigian in origin or include relatively small numbers of taxa. Given that analyses of small numbers of taxa for molecular characters can be compromised by peculiarities of long-branch attraction and nodal-density effect, it is critical that significant progress in our understanding of the relationships of these important fishes occurs with increasing sampling of species to mitigate these potential problems. The recent Cypriniformes Tree of Life initiative is an effort to achieve this goal with morphological and molecular (mitochondrial and nuclear) data. In this early synthesis of our understanding of the phylogenetic relationships of these fishes, all types of data have contributed historically to improving our understanding, but not all analyses are complementary in taxon sampling, thus precluding direct understanding of the impact of taxon sampling on achieving accurate phylogenetic inferences. However, recent molecular studies do provide some insight and in some instances taxon sampling can be implicated as a variable that can influence sister group relationships. Other instances may also exist but without inclusion of more taxa for both mitochondrial and nuclear genes, one cannot distinguish between inferences being dictated by taxon sampling or the origins of the molecular data. | Richard L. MAYDEN Kevin L. TANG Robert M. WOOD Wei-Jen CHEN Mary K. AGNEW Kevin W. CONWAY Lei YANG Andrew M. SIMONS Henry L. BART Phillip M. HARRIS Junbing LI Xuzhen WANG Kenji SAITOH Shunping HE Huanzhang LIU Yiyu CHEN Mutstmi NISHIDA Masaki MIYA | 2008 | 植物分类学报2008，46，3： | 5 |
| 9 | Clinical features and treatment outcomes of endogenous Klebsiella endophthalmitis:a 12-year review显示文摘AIM:To identify the clinical features and treatment outcomes of endogenous Klebsiella pneumoniae endophthalmitis and investigate prognostic factors of poor visual outcome.METHODS:The clinical records of all patients diagnosed with endogenous Klebsiella endophthalmitis between January 2007 to December 2018 in Prince of Wales Hospital,Hong Kong,China were retrospectively reviewed.Thorough ophthalmological examination findings were recorded in the case note,including visual acuity testing,slit-lamp examination,indirect ophthalmoscopy and B-scan ultrasonography if media opacity precluded fundus viewing.RESULTS:A total of 18 eyes in 14 patients were identified.Bilateral involvement was noted in 4 patients(28.6%).Hepatobiliary sepsis was the source in 9 patients(64.3%).Culture of intraocular fluid was positive in 5 out of 18 eyes(27.8%).Mortality was noted in 2 patients(14.3%).Mean final visual acuity was 20/1500.Six out of 16 eyes had total loss of sight(37.5%)and 3 eyes required evisceration(18.8%).Multivariate linear regression revealed poor presenting visual acuity(P=0.031)and lack of fundus view due to vitritis(P=0.02)as prognostic factors of poor visual outcome.CONCLUSION:Visual outcome of endogenous Klebsiella endophthalmitis is poor.Poor presenting visual acuity and lack of fundus view predict poor visual outcome.High index of suspicion for endophthalmitis is important in Klebsiella sepsis patients with complaints of ocular symptoms.Ophthalmological screening is recommended in noncommunicable patients with Klebsiella sepsis. | Chun Yue Mak Mary Ho Lawrence Pui-leung Iu Helena Pui-yee Sin Li Jia Chen Grace Lui Marten Erik Brelen Alvin Lerrmann Young | 2020 | International Journal of Ophthalmology(English edition)2020，13，12： | 5 |
| 10 | Establishment and characterization of a new cell line derived from human colorectal laterally spreading tumor显示文摘AIM:To study the molecular mechanism of laterally spreading tumor (LST), a cell line [Laterally Spreading Tumor-Rectum 1 (LST-R1)] was derived and the characteristics of this cell line were investigated. METHODS:A new cell line (LST-R1) originated from laterally spreading tumor was established. Properties of the cell line were characterized using scanning and transmission electron microscopy, immunohistochemistry method, cytogenetic analysis and nude mice xenograft experiments. In vitro invasion assay, cDNA microarray and Western blotting were used to compare the difference between the LST-R1 and other colorectal cancer cell lines derived from prudent colon cancer. RESULTS:Our study demonstrated that both epithelial special antigen (ESA) and cytokeratin-20 (CK20) were expressed in LST-R1. The cells presented microvilli and tight junction with large nuclei. The karyotypic analysis showed hyperdiploid features with structural chromosome aberrations. The in vivo tumorigenicity was also demonstrated in nude mice xenograft experiments. The invasion assay suggested this cell line has a higher invasive ability. cDNA microarray and Western blotting show the loss of the expression of E-cadherin in LST-R1 cells.CONCLUSION:We established and characterized a colorectal cancer cell line, LST-R1 and LST-R1 has an obvious malignant tendency, which maybe partially attributed to the changes of the expression of some adhesion molecules, such as E-cadherin. It is also a versatile tool for exploring the original and progressive mechanisms of laterally spreading tumor and the early colon cancer genesis. | Xin-Ying Wang Zhou-Sheng Lai Chung-Man Yeung Ji-De Wang Wen Deng Hoi Yee Li Yu-Jing Han Hsiang-Fu Kung Bo Jiang Marie Chia-mi Lin | 2008 | World Journal of Gastroenterology2008，14，8： | 5 |
| 11 | The Patatin-Containing Phospholipase A pPLAIIα Modulates Oxylipin Formation and Water Loss in Arabidopsis thaliana显示文摘patatin 相关的 phospholipase A (pPLA ) 水解膜 glycerolipids 将生产 monoacyl 混合物和免费的丰满的酸。Phospholipids 被 pPLAII 在 sn-1 和 sn-2 劈开包括那些包含的 oxophytodienoic 酸,位置,和 galactolipids 能也用作底层。pPLAII 的脱离减少了 lysophosphatidylcholine 和 lysophosphatidylethanolamine 层次,而是增加的免费的亚麻酸的酸。pPLAII 缺乏的植物显示了 jasmonic 酸和甲基的高水平 jasmonate,以及 oxylipin-biosynthetic 中介 13-hydroperoxylinolenic 酸和比酸的 12-oxophytodienoic 野类型(WT ) 植物。涉及 oxylipin 生产的基因的表示比在 WT 植物在 pPLAII 缺乏的异种也是更高的。变异的植物比 WT 植物更快速失去了水。WT 和变异的植物的 stomata 对 abscisic 酸同样作出回应。响应干燥,异种和 WT 叶子以一样的率生产了 abscisic 酸,,但是,在干燥的 4h 以后, jasmonic 酸水平比 WT 离开的在异种是高得多的。这些结果显示 pPLAII 否定地调整 oxylipin 生产并且从膜在氧化地修改的丰满的酸的移动建议一个角色。 | Wen-Yu Yang Yong Zheng Sung Chul Bahn Xiang-Qing Pan Mao-Yin Li Hieu Sy Vu Mary R.Roth Brad Scheu Ruth Welt Yue-Yun Hong Xue-Min Wang | 2012 | Molecular Plant2012，5，2： | 5 |
| 12 | Inattentiveness in attention-deficit/hyperactivity disorder显示文摘Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a long-term impact on functioning, productivity and quality of life of patients. This impact is largely due to the symptoms of inattentiveness. However, despite its impairing role in the lives of ADHD patients, inattentiveness has been studied relatively less frequently than have symptoms of impulsivity/hyperactivity and problems with executive function. This review therefore seeks to integrate the neuropsychological theories and current findings in the research fields of neuropsychology, neurophysiology, and neuroimaging, in an attempt to gain a more complete understanding of the role that inattentiveness plays in ADHD, as well as to suggest directions for future studies. The need for a more comprehensive understanding of inattentiveness and ADHD, which integrates findings from each of the three disciplines mentioned above, is emphasized. | Ariane Sroubek Mary Kelly Xiaobo Li | 2013 | Neuroscience Bulletin2013，29，1： | 4 |
| 13 | A multi-center, double-blind, randomized, parallel group study to evaluate the effects of two different doses of losartan on morbidity and mortality in Chinese patients with symptomatic heart failure intolerant of angiotensin converting enzyme inhibitor treatment显示文摘 | HU Da-yi HUANG Jun CAI Nai-sheng ZHU Wen-ling LI Yi-shi Rachid Massaad Mary E. Hanson Kenneth Dickstein | 2012 | Chinese Medical Journal2012，，21： | 4 |
| 14 | Mechanical strength of wheat grain varieties influenced by moisture content and loading rate显示文摘Mechanical shear resistance of wheat grain is a significant concern for the designers and researchers related to the design of threshing,handling and processing machinery of the field crops.The grain mechanical properties directly affect the machine geometry and its operational parameters.The present study was carried out to determine the shear resistance of five wheat varieties(Locally names;TD-02,Sindhu-1105,Benazir,China and SKD-118)influenced by moisture content(16.7%,18.7%and 19.5%)and loading rate(3 mm/s,6 mm/s and 9 mm/s).However,some physio-dimensional properties(length,width,thickness,slenderness ratio,surface area and sphericity)were obtained at different moisture contents.The results showed that the shear resistance reduced by increasing the moisture content and loading rate.The average shear resistance decreased from 10.45 N to 3.74 N for 3-9 mm/s loading rate at moisture content of 16.7%to 19.5%.Thus,the maximum correlation(r=0.905)of shear resistance obtained at 16.7%,whereas minimum correlation(r=0.692)obtained at 19.5%.The shear resistance of wheat grain was highly significant(p<0.05)at 9 mm/s for 19.5%.Shear resistance decreased with an increase in the moisture content in the grain whereas deformation is increasing with the increase of moisture content.However,the maximum bulk density of wheat grain obtained at 19.5%for SKD-118,while the minimum obtained at 16.7%for TD-02.It is recommended that the design and modification of wheat grain processing equipment should be executed on the physio-mechanical properties of grain varieties. | Yaoming Li Farman Ali Chandio Zheng Ma Imran Ali Lakhiar Abdul Razaque Sahito Fiaz Ahmad Irshad Ali Mari Umer Farooq Muhammad Suleman | 2018 | International Journal of Agricultural and Biological Engineering2018，11，4： | 4 |
| 15 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 16 | The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor显示文摘 | Anne E. Powell Yang Wang Yina Li Emily J. Poulin Anna L. Means Mary K. Washington James N. Higginbotham Alwin Juchheim Nripesh Prasad Shawn E. Levy Yan Guo Yu Shyr Bruce J. Aronow Kevin M. Haigis Jeffrey L. Franklin Robert J. Coffey | 2012 | Cell2012，，1： | 2 |
| 17 | Cell:癌基因“遗传平衡”或会影响患者对癌症疗法的反应显示文摘进行癌症疗法的选择越来越需要确定肿瘤细胞中是否含有一些特殊突变的癌基因会驱动癌细胞异常生长。并且确定是否癌细胞会对特殊药物耐受或敏感.近日来自加州大学旧金山分校的研究人员就通过研究发现。以常见的癌基因KRAs突变为例。患者对疗法的反应往往会随着肿瘤的不断进化而发生改变。相关研究刊登于国际杂志Cell上。 | Michael R. Burgess Eugene Hwang Rana Mroue Craig M. Bielski Anica M. Wandler Benjamin J. Huang Ari J. Firestone Amy Young Jennifer A. Lacap Lisa Crocker Saurabh Asthana Elizabeth M. Davis Jin Xu Keiko Akagi Michelle M. Le Beau Qing Li Benjamin Haley David Stokoe Deepak Sampath Barry S. Taylor Marie Evangelista Kevin Shannon | 2017 | 现代生物医学进展2017，17，18： | 2 |
| 18 | Transcriptome analysis of near-isogenic lines provides molecular insights into starch biosynthesis in maize kernel显示文摘Starch is the major component in maize kernels,providing a stable carbohydrate source for humans and livestock as well as raw material for the biofuel industry.Increasing maize kernel starch content will help meet industry demands and has the potential to increase overall yields.We developed a pair of maize near-isogenic lines(NILs) with different alleles for a starch quantitative trait locus on chromosome 3(q HS3), resulting in different kernel starch content. To investigate the candidate genes for q HS3 and elucidate their effects on starch metabolism, RNA-Seq was performed for the developing kernels of the NILs at 14 and 21 d after pollination(DAP). Analysis of genomic and transcriptomic data identified 76 genes with nonsynonymous single nucleotide polymorphisms and 384 differentially expressed genes(DEGs) in the in trogressed fragment, including a hexokinase gene, Zm HXK3 a, which catalyzes the conversion of glucose to glucose-6-phosphate and may play a key role instarch metabolism. The expression pattern of all DEGs in starch metabolism shows that altered expression of the candidate genes for q HS3 promoted starch synthesis,with positive consequences for kernel starch content. These results expand the current understanding of starch biosynthesis and accumulation in maize kernels and provide potential candidate genes to increase starch content. | Yingni Xiao Shawn Thatcher Min Wang Tingting Wang Mary Beatty Gina Zastrow-Hayes Lin Li Jiansheng Li Bailin Li Xiaohong Yang | 2016 | Journal of Integrative Plant Biology2016，58，8： | 2 |
| 19 | A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations显示文摘 | Sreenath V. Sharma Diana Y. Lee Bihua Li Margaret P. Quinlan Fumiyuki Takahashi Shyamala Maheswaran Ultan McDermott Nancy Azizian Lee Zou Michael A. Fischbach Kwok-Kin Wong Kathleyn Brandstetter Ben Wittner Sridhar Ramaswamy Marie Classon Jeff Settleman | 2010 | Cell2010，，1： | 2 |
| 20 | The COVID-19 pandemic and physical activity显示文摘The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health,economy,and lifestyle.Although the virus usually first invades and infects the lung and respiratory track tissue,in extreme cases,almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some people.Unfortunately,there is currently no effective treatment for this disease.Pre-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and mortality.The immobilization due to hospitalization and bed rest and the physical inactivity due to sustained quarantine and social distancing can downregulate the ability of organs systems to resist to viral infection and increase the risk of damage to the immune,respiratory,cardiovascular,musculoskeletal systems and the brain.The cellular mechanisms and danger of this“second wave”effect of COVID-19 to the human body,along with the effects of aging,proper nutrition,and regular physical activity,are reviewed in this article. | Jeffrey A.Woods Noah T.Hutchinson Scott K.Powers William O.Roberts Mari Carmen Gomez-Cabrera Zsolt Radak Istvan Berkes Anita Boros Istvan Boldogh Christiaan Leeuwenburgh Helio Jose Coelho-Júnior Emanuele Marzetti Ying Cheng Jiankang Liu J.Larry Durstine Junzhi Sun Li Li Ji | 2020 | Sports Medicine and Health Science2020，2，2： | 2 |
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