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6篇 您的检索式:作者名="Masamitsu A"
    题名 作者 年代 出处 被引量
1Advanced heating technologies applying regenerative heat exchange systems to energy saving显示文摘KAZUNARI A TSUGHIKO N MASAMITSU O 2002Kawasaki Steel Technical Report2002,46,6:1
2Blood blister-like aneurysms of the internal caroti dartery显示文摘Masamitsu A Kazuo T Hiroaki Y 1995J Neurosurg1995,89,:1
3Blood blister- like aneurysms of the internal carotid artery 显示文摘Masamitsu A Kazuo T Hiroaki Y 1998J Neuro- surg1998,89,:1
4Designing paper type wet friction material for high strength and durability显示文摘Katsuhiro I Barker K A Masamitsu K 1998SAE Technical Paper1998,,:1
5Long-term reliability of AAI mode pacing in patients with sinus node dysfunction and low wenckebach block rate显示文摘Masamitsu A Osamu L Akio Y 2008Europace2008,10,2:1
6Repetitive administration of cultured human CD34+cells improve adenine-induced kidney injury in mice显示文摘BACKGROUND There is no established treatment to impede the progression or restore kidney function in human chronic kidney disease(CKD).AIM To examine the efficacy of cultured human CD34+cells with enhanced proliferating potential in kidney injury in mice.METHODS Human umbilical cord blood(UCB)-derived CD34+cells were incubated for one week in vasculogenic conditioning medium.Vasculogenic culture significantly increased the number of CD34+cells and their ability to form endothelial progenitor cell colony-forming units.Adenineinduced tubulointerstitial injury of the kidney was induced in immunodeficient non-obese diabetic/severe combined immunodeficiency mice,and cultured human UCB-CD34+cells were administered at a dose of 1×106/mouse on days 7,14,and 21 after the start of adenine diet.RESULTS Repetitive administration of cultured UCB-CD34+cells significantly improved the time-course of kidney dysfunction in the cell therapy group compared with that in the control group.Both interstitial fibrosis and tubular damage were significantly reduced in the cell therapy group compared with those in the control group(P<0.01).Microvasculature integrity was significantly preserved(P<0.01)and macrophage infiltration into kidney tissue was dramatically decreased in the cell therapy group compared with those in the control group(P<0.001).CONCLUSION Early intervention using human cultured CD34+cells significantly improved the progression of tubulointerstitial kidney injury.Repetitive administration of cultured human UCB-CD34+cells significantly improved tubulointerstitial damage in adenine-induced kidney injury in mice via vasculoprotective and anti-inflammatory effects.Takayasu Ohtake Shoichi Itaba Amankeldi A Salybekov Yin Sheng Tsutomu Sato Mitsuru Yanai Makoto Imagawa Shigeo Fujii Hiroki Kumagai Masamitsu Harata Takayuki Asahara Shuzo Kobayashi 2023World Journal of Stem Cells2023,15,4:0
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