|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pre-operative Nomogram to Predict Risk of Peri-operative Mortality following Liver Resections for Malignancy显示文摘 | Mashaal Dhir Lynette M. Smith Fred Ullrich Premila D. Leiphrakpam Quan P. Ly Aaron R. Sasson Chandrakanth Are | 2010 | Journal of Gastrointestinal Surgery2010，，11： | 1 |
| 2 | Sessile serrated adenomas and classical adenomas: An epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract显示文摘 | Mashaal Dhir Shinichi Yachida Leander Van Neste Sabine C. Gl?ckner Jana Jeschke Emmanouil P. Pappou Elizabeth A. Montgomery James G. Herman Stephen B. Baylin Christine Iacobuzio‐Donahue Nita Ahuja | 2011 | Int. J. Cancer2011，，： | 1 |
| 3 | Egypt information, prevention, and treatment of chronic kidney disease (EGIPT-CKD) programme: Prevalence and risk factors for microalbuminuria among the relatives of patients with CKD in Egypt显示文摘 | Gouda Z Mashaal G Bello A | 2011 | Saudi Journal of Kidney Diseases and Transplantation2011，22，5： | 1 |
| 4 | Comparison of outcomes of transplantation and resection in patients with early hepatocellular carcinoma: a meta‐analysis显示文摘 | Mashaal Dhir Elizabeth R. Lyden Lynette M. Smith Chandrakanth Are | 2012 | HPB2012，，9： | 1 |
| 5 | Pre-operative Nomogram to Predict Risk of Peri-operative Mortality following Liver Resections for Malignancy显示文摘 | Mashaal Dhir Lynette M. Smith Fred Ullrich Premila D. Leiphrakpam Quan P. Ly Aaron R. Sasson Chandrakanth Are | 2010 | Journal of Gastrointestinal Surgery2010，，11： | 1 |
| 6 | Comparison of outcomes of transplantation and resection in patients with early hepatocellular carcinoma: a meta‐analysis显示文摘 | Mashaal Dhir Elizabeth R. Lyden Lynette M. Smith Chandrakanth Are | 2012 | HPB2012，，9： | 1 |
| 7 | 小叶苦丁提取物通过上调Nrf2/INS蛋白质水平表达降低小鼠高血糖显示文摘近年来,高血糖的患病率不断增加,患者身体损伤严重。与常规西药相比,天然产物不良反应少,可延缓高血糖并发症。小叶苦丁是一种珍贵的天然产品资源,含有多种对人体有益的成分。本研究旨在研究不同剂量的小叶苦丁提取物对高血糖小鼠血糖代谢的调节作用。本研究采用脂多糖加链脲佐菌素诱导小鼠高血糖模型,小叶苦丁提取物以低、中、高(5g·kg^(-1)·d-1,10g·kg^(-1)·d-1,15g·kg^(-1)·d-1)3个剂量灌胃给药,连续7周。每周于固定时间采集小鼠尾静脉血测定小鼠空腹血糖值。给药7周后,按规定取每只小鼠的血清和脏器,测定血清中甘油三酯(TG)、胆固醇(CHO)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、糖化血清蛋白(GSP)、胰高血糖素样肽-1(GLP-1)、空腹胰岛素(FINS)和胰高血糖素(GC)含量水平。结果显示,模型组小鼠血糖值、各项血清生化指标与正常组小鼠均具有显著性差异(P<0.01或P<0.05),高血糖症状明显。小叶苦丁提取物低、中、高剂量组HDL-C、FINS含量显著高于模型组(P<0.01),TG、CHO、LDL-C含量减少,血糖值显著降低,与模型组相比具有极显著性差异(P<0.01)。中、高剂量组GSP含量较模型组显著降低(P<0.01或P<0.05)。小鼠胰腺组织的H&E染色结果显示,高血糖小鼠在灌胃小叶苦丁提取物后,胰岛细胞形态有所改善;免疫组织化学法观察胰腺组织胰岛素、核因子E2相关因子2蛋白质水平的表达,并采用免疫印迹实验(WB)和实时荧光定量(RT-qPCR)验证。结果表明,胰岛素(INS)、核因子E2相关因子2(Nrf2)蛋白质表达水平上调,其中高剂量组效果最佳(P<0.01)。以上结果提示,小叶苦丁提取物能够降低高血糖小鼠的血糖值,对其胰岛细胞损伤具有改善作用,能够改善高血糖小鼠症状,为临床治疗高血糖提供了新参考。 | 陈明娟 韦仕南 MASHAAL Ahmad 余佳 程莎 谢伯银 毛远忠 骆衡 | 2023 | 中国生物化学与分子生物学报2023，39，8： | 0 |
| 8 | Therapeutic values of chick early amniotic fluid(ceAF)that facilitates wound healing via potentiating a SASP-mediated transient senescence显示文摘Inflammatory,proliferative and remodeling phases constitute a cutaneous wound healing program.Therapeutic applications and medication are available;however,they commonly are comprised of fortified preservatives that might prolong the healing process.Chick early amniotic fluids(ceAF)contain native therapeutic factors with balanced chemokines,cytokines and growth-related factors;their origins in principle dictate no existence of harmful agents that would otherwise hamper embryo development.Instead,they possess a spectrum of molecules driving expeditious mitotic divisions and possibly exerting other functions.Employing both in vitro and in vivo models,we examined ceAF's therapeutic potentials in wound healing and found intriguing involvement of transient senescence,known to be intimately intermingled with Senescence Associated Secretory Phenotypes(SASP)that function in addition to or in conjunction with ceAF to facilitate wound healing.In our cutaneous wound healing models,a low dose of ceAF exhibited the best efficacies;however,higher doses attenuated the wound healing presumably by inducing p16 expression over a threshold.Our studies thus link an INK4/ARF locus-mediated signaling cascade to cutaneous wound healing,suggesting therapeutic potentials of ceAF exerting functions likely by driving transient senescence,expediting cellular proliferation,migration,and describing a homeostatic and balanced dosage strategy in medical intervention. | Mashaal Ahmad Yandi Sun Xueyao Jia Jingjia Li Lihong Zhang Ze Yang Yindan Lin Xueyun Zhang Zara Ahmad Khan Jin Qian Yan Luo | 2022 | Genes & Diseases2022，9，5： | 0 |
| 9 | 结直肠癌肝转移行肝切除术的切缘对患者总生存期影响的Meta分析显示文摘手术切缘是结直肠癌肝转移行肝切除术患者的重要预后因素。阳性切缘相对于阴性切缘预后不佳目前已有共识,但对阴性切缘的范围仍存争议。本研究的目的是通过对已报道的结直肠癌肝转移行肝切除术的病例进行Meta分析,判断大于或等于1cm的阴性切缘相对于小于1cm的阴性切缘是否具有生存优势(切缘针对肝脏病灶)。 | Mashaal Dhir 曹希(摘译) 林国乐(校) | 2011 | 中华胃肠外科杂志2011，14，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员